P16 detection in benign, precursor epithelial lesions and carcinomas of head and neck
Human papillomavirus (HPV) had recently been implicated in the pathogenesis of Head and Neck SCCs. The biological role of HPV in benign and pre-cancerous lesions is far less studied. p16 is a widely accepted marker to detect immonohistochemically the presence of HPV. We evaluated, immunohistochemica...
Gespeichert in:
| Veröffentlicht in: | Pathology, research and practice research and practice, 2020-08, Vol.216 (8), p.153035-153035, Article 153035 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 153035 |
|---|---|
| container_issue | 8 |
| container_start_page | 153035 |
| container_title | Pathology, research and practice |
| container_volume | 216 |
| creator | Chatzipantelis, Paschalis Koukourakis, Michail Kouroupi, Maria Giatromanolaki, Alexandra |
| description | Human papillomavirus (HPV) had recently been implicated in the pathogenesis of Head and Neck SCCs. The biological role of HPV in benign and pre-cancerous lesions is far less studied. p16 is a widely accepted marker to detect immonohistochemically the presence of HPV.
We evaluated, immunohistochemically, expression of p16 in 212 specimens: glottis, supraglottis, oropharynx, nasal/paranasal, with various diagnoses: hyperplasia, polyp/nodule, keratosis, papilloma, inverted papilloma, dysplasia, cancer (SCC). Analysis was completed according to location and disease.
Hyperplasias/polyps were all negative for p16. A small percentage of papillomas was p16+ regardless of their location (12.5 %), the majority of inverted papillomas were p16+ (78.6 %) and statistically significant (p |
| doi_str_mv | 10.1016/j.prp.2020.153035 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2427308088</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0344033820310268</els_id><sourcerecordid>2427308088</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-8e9e1ac91bd7fd252a3e225203da8d4a9a9332f74e45855a5eaff5979f3049e73</originalsourceid><addsrcrecordid>eNp9kD1PwzAQhi0EoqXwA1iQRwZS_BEnjphQxZdUCQY6W659oS6pE-wEiX-PSwsj0-nunnulexA6p2RKCS2u19MudFNGWOoFJ1wcoDEtqMxIwekhGhOe5xnhXI7QSYxrQkhJcnqMRpyVaVfJMVq80AJb6MH0rvXYebwE7978Fe4CmCHENmDoXL-CxukGNxATFrH2FhsdjPPtRkfc1ngF2v6MPZj3U3RU6ybC2b5O0OL-7nX2mM2fH55mt_PMcMH7TEIFVJuKLm1ZWyaY5sBSIdxqaXNd6YpzVpc55EIKoQXouhZVWdWc5BWUfIIud7ldaD8GiL3auGigabSHdoiK5azkRBIpE0p3qAltjAFq1QW30eFLUaK2NtU6TTq1tal2NtPNxT5-WG7A_l386kvAzQ6A9OSng6CiceANWJfs9cq27p_4b7h8hFk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2427308088</pqid></control><display><type>article</type><title>P16 detection in benign, precursor epithelial lesions and carcinomas of head and neck</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Chatzipantelis, Paschalis ; Koukourakis, Michail ; Kouroupi, Maria ; Giatromanolaki, Alexandra</creator><creatorcontrib>Chatzipantelis, Paschalis ; Koukourakis, Michail ; Kouroupi, Maria ; Giatromanolaki, Alexandra</creatorcontrib><description>Human papillomavirus (HPV) had recently been implicated in the pathogenesis of Head and Neck SCCs. The biological role of HPV in benign and pre-cancerous lesions is far less studied. p16 is a widely accepted marker to detect immonohistochemically the presence of HPV.
We evaluated, immunohistochemically, expression of p16 in 212 specimens: glottis, supraglottis, oropharynx, nasal/paranasal, with various diagnoses: hyperplasia, polyp/nodule, keratosis, papilloma, inverted papilloma, dysplasia, cancer (SCC). Analysis was completed according to location and disease.
Hyperplasias/polyps were all negative for p16. A small percentage of papillomas was p16+ regardless of their location (12.5 %), the majority of inverted papillomas were p16+ (78.6 %) and statistically significant (p < 0.04). In carcinomas, 18/59 were p16+ (30.5 %): nasal/paranasal SCCs had a significantly higher percentage of p16+ cancer cells compared to glottis (p = 0.009), while tumours of the supraglottis/oropharynx had an intermediate score for p16+ cells (p = 0.07). Dysplasias were p16+ in 9/64 (14 %) regardless of grading (p = 0.03 compared to carcinomas).
p16 was highly detected in inverted papillomas and in certain anatomic sites; however, it failed to be traced in benign lesions and only rarely encountered in dysplasias.</description><identifier>ISSN: 0344-0338</identifier><identifier>EISSN: 1618-0631</identifier><identifier>DOI: 10.1016/j.prp.2020.153035</identifier><identifier>PMID: 32703498</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Adult ; Aged ; Biomarkers, Tumor - analysis ; Cancer ; Cyclin-Dependent Kinase Inhibitor p16 - analysis ; Dysplasia ; Female ; Head and neck ; Head and Neck Neoplasms - virology ; Humans ; Hyperplasia - virology ; Inverted Papillomas ; Male ; Middle Aged ; p16 ; Papilloma, Inverted - virology ; Papillomavirus Infections - complications ; Papillomavirus Infections - epidemiology ; Precancerous Conditions - virology ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck - virology</subject><ispartof>Pathology, research and practice, 2020-08, Vol.216 (8), p.153035-153035, Article 153035</ispartof><rights>2020 Elsevier GmbH</rights><rights>Copyright © 2020 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-8e9e1ac91bd7fd252a3e225203da8d4a9a9332f74e45855a5eaff5979f3049e73</citedby><cites>FETCH-LOGICAL-c353t-8e9e1ac91bd7fd252a3e225203da8d4a9a9332f74e45855a5eaff5979f3049e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0344033820310268$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32703498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chatzipantelis, Paschalis</creatorcontrib><creatorcontrib>Koukourakis, Michail</creatorcontrib><creatorcontrib>Kouroupi, Maria</creatorcontrib><creatorcontrib>Giatromanolaki, Alexandra</creatorcontrib><title>P16 detection in benign, precursor epithelial lesions and carcinomas of head and neck</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description>Human papillomavirus (HPV) had recently been implicated in the pathogenesis of Head and Neck SCCs. The biological role of HPV in benign and pre-cancerous lesions is far less studied. p16 is a widely accepted marker to detect immonohistochemically the presence of HPV.
We evaluated, immunohistochemically, expression of p16 in 212 specimens: glottis, supraglottis, oropharynx, nasal/paranasal, with various diagnoses: hyperplasia, polyp/nodule, keratosis, papilloma, inverted papilloma, dysplasia, cancer (SCC). Analysis was completed according to location and disease.
Hyperplasias/polyps were all negative for p16. A small percentage of papillomas was p16+ regardless of their location (12.5 %), the majority of inverted papillomas were p16+ (78.6 %) and statistically significant (p < 0.04). In carcinomas, 18/59 were p16+ (30.5 %): nasal/paranasal SCCs had a significantly higher percentage of p16+ cancer cells compared to glottis (p = 0.009), while tumours of the supraglottis/oropharynx had an intermediate score for p16+ cells (p = 0.07). Dysplasias were p16+ in 9/64 (14 %) regardless of grading (p = 0.03 compared to carcinomas).
p16 was highly detected in inverted papillomas and in certain anatomic sites; however, it failed to be traced in benign lesions and only rarely encountered in dysplasias.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Cancer</subject><subject>Cyclin-Dependent Kinase Inhibitor p16 - analysis</subject><subject>Dysplasia</subject><subject>Female</subject><subject>Head and neck</subject><subject>Head and Neck Neoplasms - virology</subject><subject>Humans</subject><subject>Hyperplasia - virology</subject><subject>Inverted Papillomas</subject><subject>Male</subject><subject>Middle Aged</subject><subject>p16</subject><subject>Papilloma, Inverted - virology</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - epidemiology</subject><subject>Precancerous Conditions - virology</subject><subject>Retrospective Studies</subject><subject>Squamous Cell Carcinoma of Head and Neck - virology</subject><issn>0344-0338</issn><issn>1618-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwA1iQRwZS_BEnjphQxZdUCQY6W659oS6pE-wEiX-PSwsj0-nunnulexA6p2RKCS2u19MudFNGWOoFJ1wcoDEtqMxIwekhGhOe5xnhXI7QSYxrQkhJcnqMRpyVaVfJMVq80AJb6MH0rvXYebwE7978Fe4CmCHENmDoXL-CxukGNxATFrH2FhsdjPPtRkfc1ngF2v6MPZj3U3RU6ybC2b5O0OL-7nX2mM2fH55mt_PMcMH7TEIFVJuKLm1ZWyaY5sBSIdxqaXNd6YpzVpc55EIKoQXouhZVWdWc5BWUfIIud7ldaD8GiL3auGigabSHdoiK5azkRBIpE0p3qAltjAFq1QW30eFLUaK2NtU6TTq1tal2NtPNxT5-WG7A_l386kvAzQ6A9OSng6CiceANWJfs9cq27p_4b7h8hFk</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Chatzipantelis, Paschalis</creator><creator>Koukourakis, Michail</creator><creator>Kouroupi, Maria</creator><creator>Giatromanolaki, Alexandra</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202008</creationdate><title>P16 detection in benign, precursor epithelial lesions and carcinomas of head and neck</title><author>Chatzipantelis, Paschalis ; Koukourakis, Michail ; Kouroupi, Maria ; Giatromanolaki, Alexandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-8e9e1ac91bd7fd252a3e225203da8d4a9a9332f74e45855a5eaff5979f3049e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Cancer</topic><topic>Cyclin-Dependent Kinase Inhibitor p16 - analysis</topic><topic>Dysplasia</topic><topic>Female</topic><topic>Head and neck</topic><topic>Head and Neck Neoplasms - virology</topic><topic>Humans</topic><topic>Hyperplasia - virology</topic><topic>Inverted Papillomas</topic><topic>Male</topic><topic>Middle Aged</topic><topic>p16</topic><topic>Papilloma, Inverted - virology</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - epidemiology</topic><topic>Precancerous Conditions - virology</topic><topic>Retrospective Studies</topic><topic>Squamous Cell Carcinoma of Head and Neck - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chatzipantelis, Paschalis</creatorcontrib><creatorcontrib>Koukourakis, Michail</creatorcontrib><creatorcontrib>Kouroupi, Maria</creatorcontrib><creatorcontrib>Giatromanolaki, Alexandra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology, research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chatzipantelis, Paschalis</au><au>Koukourakis, Michail</au><au>Kouroupi, Maria</au><au>Giatromanolaki, Alexandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P16 detection in benign, precursor epithelial lesions and carcinomas of head and neck</atitle><jtitle>Pathology, research and practice</jtitle><addtitle>Pathol Res Pract</addtitle><date>2020-08</date><risdate>2020</risdate><volume>216</volume><issue>8</issue><spage>153035</spage><epage>153035</epage><pages>153035-153035</pages><artnum>153035</artnum><issn>0344-0338</issn><eissn>1618-0631</eissn><abstract>Human papillomavirus (HPV) had recently been implicated in the pathogenesis of Head and Neck SCCs. The biological role of HPV in benign and pre-cancerous lesions is far less studied. p16 is a widely accepted marker to detect immonohistochemically the presence of HPV.
We evaluated, immunohistochemically, expression of p16 in 212 specimens: glottis, supraglottis, oropharynx, nasal/paranasal, with various diagnoses: hyperplasia, polyp/nodule, keratosis, papilloma, inverted papilloma, dysplasia, cancer (SCC). Analysis was completed according to location and disease.
Hyperplasias/polyps were all negative for p16. A small percentage of papillomas was p16+ regardless of their location (12.5 %), the majority of inverted papillomas were p16+ (78.6 %) and statistically significant (p < 0.04). In carcinomas, 18/59 were p16+ (30.5 %): nasal/paranasal SCCs had a significantly higher percentage of p16+ cancer cells compared to glottis (p = 0.009), while tumours of the supraglottis/oropharynx had an intermediate score for p16+ cells (p = 0.07). Dysplasias were p16+ in 9/64 (14 %) regardless of grading (p = 0.03 compared to carcinomas).
p16 was highly detected in inverted papillomas and in certain anatomic sites; however, it failed to be traced in benign lesions and only rarely encountered in dysplasias.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>32703498</pmid><doi>10.1016/j.prp.2020.153035</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0344-0338 |
| ispartof | Pathology, research and practice, 2020-08, Vol.216 (8), p.153035-153035, Article 153035 |
| issn | 0344-0338 1618-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2427308088 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Biomarkers, Tumor - analysis Cancer Cyclin-Dependent Kinase Inhibitor p16 - analysis Dysplasia Female Head and neck Head and Neck Neoplasms - virology Humans Hyperplasia - virology Inverted Papillomas Male Middle Aged p16 Papilloma, Inverted - virology Papillomavirus Infections - complications Papillomavirus Infections - epidemiology Precancerous Conditions - virology Retrospective Studies Squamous Cell Carcinoma of Head and Neck - virology |
| title | P16 detection in benign, precursor epithelial lesions and carcinomas of head and neck |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T13%3A42%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=P16%20detection%20in%20benign,%20precursor%20epithelial%20lesions%20and%20carcinomas%20of%20head%20and%20neck&rft.jtitle=Pathology,%20research%20and%20practice&rft.au=Chatzipantelis,%20Paschalis&rft.date=2020-08&rft.volume=216&rft.issue=8&rft.spage=153035&rft.epage=153035&rft.pages=153035-153035&rft.artnum=153035&rft.issn=0344-0338&rft.eissn=1618-0631&rft_id=info:doi/10.1016/j.prp.2020.153035&rft_dat=%3Cproquest_cross%3E2427308088%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2427308088&rft_id=info:pmid/32703498&rft_els_id=S0344033820310268&rfr_iscdi=true |