Phosphate-dependent aggregation of KLn peptides affects their membranolytic activity

In this study, we investigate how the length of amphiphilic β-sheet forming peptides affects their interaction with membranes. Four polycationic model peptides with lengths from 6 to 18 amino acids were constructed from simple Lys-Leu repeats, giving [KL]n=3,5,7,9. We found that (1) they exhibit a p...

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Veröffentlicht in:	Scientific reports 2020-07, Vol.10 (1), p.12300
Hauptverfasser:	Strandberg, Erik, Schweigardt, Fabian, Wadhwani, Parvesh, Bürck, Jochen, Reichert, Johannes, Cravo, Haroldo L P, Burger, Luisa, Ulrich, Anne S
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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