Salidroside alleviated hypoxia-induced liver injury by inhibiting endoplasmic reticulum stress-mediated apoptosis via IRE1α/JNK pathway

Endoplasmic reticulum (ER) stress and subsequent apoptosis played vital role in liver injury and dysfunction. The aim of this study was to investigate the protective effect and mechanism of salidroside on hypoxia induced liver injury both in vivo and in vitro. Male SD rats were exposed to hypobaric...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 2020-08, Vol.529 (2), p.335-340
Hauptverfasser:	Xiong, Yanlei, Wang, Yueming, Xiong, Yanlian, Gao, Wei, Teng, Lianghong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Cell Line Endoplasmic reticulum stress Endoplasmic Reticulum Stress - drug effects Endoribonucleases - metabolism Glucosides - therapeutic use Humans Hypoxia Hypoxia - complications Hypoxia - drug therapy Hypoxia - metabolism IRE1α Liver Diseases - drug therapy Liver Diseases - etiology Liver Diseases - metabolism Male MAP Kinase Kinase 4 - metabolism Multienzyme Complexes - metabolism Phenols - therapeutic use Protective Agents - therapeutic use Protein-Serine-Threonine Kinases - metabolism Rats, Sprague-Dawley Salidroside Signal Transduction - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!