Utility of narrow band imaging in predicting histology in celiac disease
Background Narrow band imaging (NBI) with magnification better visualizes the duodenal microsurface and mucosal vascularity. NBI delineates villous atrophy better than conventional white light endoscopy. Aims This study was conducted to evaluate the diagnostic accuracy of narrow band imaging with ma...
Gespeichert in:
| Veröffentlicht in: | Indian journal of gastroenterology 2020-08, Vol.39 (4), p.370-376 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 376 |
|---|---|
| container_issue | 4 |
| container_start_page | 370 |
| container_title | Indian journal of gastroenterology |
| container_volume | 39 |
| creator | Sinha, Saroj Kant Berry, Neha Muktesh, Gaurav Siddappa, Pradeep Basha, Jahangeer Prasad, Kaushal Appasani, Sreekanth Ashat, Munish Vaiphei, Kim Singh, Kartar Kochhar, Rakesh |
| description | Background
Narrow band imaging (NBI) with magnification better visualizes the duodenal microsurface and mucosal vascularity. NBI delineates villous atrophy better than conventional white light endoscopy.
Aims
This study was conducted to evaluate the diagnostic accuracy of narrow band imaging with magnification (NBI-ME) in celiac disease (CD).
Methods
In this prospective study, consecutive patients of suspected CD and controls were subjected to tissue transglutaminase antibody test and endoscopic evaluation initially with white light followed by NBI-ME, and biopsies were taken from duodenum. Duodenal villous patterns on NBI were interpreted as normal, blunted distorted, and absent. Severity of villous atrophy was reported according to the modified Marsh criteria.
Results
One hundred and twenty-two patients (mean age of 27.53 ± 13.37 years and a male to female ratio of 1:1.26) and 40 controls were studied. The sensitivity and specificity of NBI-ME in predicting villous atrophy were found to be 95.54% and 90%, respectively. The specificity and negative predictive value of NBI-ME in predicting villous atrophy amongst controls was 100% and 97.5%, respectively. Abnormal findings (blunted and absent villous patterns) combined with elevated transglutaminase antibody (> 5-fold) were found to have high accuracy in predicting villous atrophy.
Conclusion
NBI with magnification has high sensitivity and specificity in predicting villous atrophy in patients with celiac disease. |
| doi_str_mv | 10.1007/s12664-020-01030-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2427304126</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2427304126</sourcerecordid><originalsourceid>FETCH-LOGICAL-c324t-a032d7e2389eb47f1add31364b0c21c39f29075a1851828031f2ed736d5a0fa3</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EEqXwA6y8ZGOYsZ04WaKKl1SJTVlbbuwEV2lc7FSof49DWLOah-4dzT2E3CLcI4B6SMjLUjLgwABBAMMzsoBaFQwU4nnueSFZVZVwSa5S2sE012JBXj9G3_vxRENLBxNj-KZbM1jq96bzQ0f9QA_RWd-M0_Tp0xj60J2mfeN6bxpqfXImuWty0Zo-uZu_uiSb56fN6pWt31_eVo9r1gguR2ZAcKscF1XttlK1aKwVKEq5hYZjI-qW16AKg1WBFa9AYMudVaK0hYHWiCW5m88eYvg6ujTqvU_5k94MLhyT5pIrATLjyFI-S5sYUoqu1YeYY8WTRtATNT1T05ma_qWmMZvEbEpZPHQu6l04xiEn-s_1A169bt4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2427304126</pqid></control><display><type>article</type><title>Utility of narrow band imaging in predicting histology in celiac disease</title><source>Springer Online Journals</source><creator>Sinha, Saroj Kant ; Berry, Neha ; Muktesh, Gaurav ; Siddappa, Pradeep ; Basha, Jahangeer ; Prasad, Kaushal ; Appasani, Sreekanth ; Ashat, Munish ; Vaiphei, Kim ; Singh, Kartar ; Kochhar, Rakesh</creator><creatorcontrib>Sinha, Saroj Kant ; Berry, Neha ; Muktesh, Gaurav ; Siddappa, Pradeep ; Basha, Jahangeer ; Prasad, Kaushal ; Appasani, Sreekanth ; Ashat, Munish ; Vaiphei, Kim ; Singh, Kartar ; Kochhar, Rakesh</creatorcontrib><description>Background
Narrow band imaging (NBI) with magnification better visualizes the duodenal microsurface and mucosal vascularity. NBI delineates villous atrophy better than conventional white light endoscopy.
Aims
This study was conducted to evaluate the diagnostic accuracy of narrow band imaging with magnification (NBI-ME) in celiac disease (CD).
Methods
In this prospective study, consecutive patients of suspected CD and controls were subjected to tissue transglutaminase antibody test and endoscopic evaluation initially with white light followed by NBI-ME, and biopsies were taken from duodenum. Duodenal villous patterns on NBI were interpreted as normal, blunted distorted, and absent. Severity of villous atrophy was reported according to the modified Marsh criteria.
Results
One hundred and twenty-two patients (mean age of 27.53 ± 13.37 years and a male to female ratio of 1:1.26) and 40 controls were studied. The sensitivity and specificity of NBI-ME in predicting villous atrophy were found to be 95.54% and 90%, respectively. The specificity and negative predictive value of NBI-ME in predicting villous atrophy amongst controls was 100% and 97.5%, respectively. Abnormal findings (blunted and absent villous patterns) combined with elevated transglutaminase antibody (> 5-fold) were found to have high accuracy in predicting villous atrophy.
Conclusion
NBI with magnification has high sensitivity and specificity in predicting villous atrophy in patients with celiac disease.</description><identifier>ISSN: 0254-8860</identifier><identifier>EISSN: 0975-0711</identifier><identifier>DOI: 10.1007/s12664-020-01030-1</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Gastroenterology ; Hepatology ; Medicine ; Medicine & Public Health ; Original Article</subject><ispartof>Indian journal of gastroenterology, 2020-08, Vol.39 (4), p.370-376</ispartof><rights>Indian Society of Gastroenterology 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c324t-a032d7e2389eb47f1add31364b0c21c39f29075a1851828031f2ed736d5a0fa3</citedby><cites>FETCH-LOGICAL-c324t-a032d7e2389eb47f1add31364b0c21c39f29075a1851828031f2ed736d5a0fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12664-020-01030-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12664-020-01030-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Sinha, Saroj Kant</creatorcontrib><creatorcontrib>Berry, Neha</creatorcontrib><creatorcontrib>Muktesh, Gaurav</creatorcontrib><creatorcontrib>Siddappa, Pradeep</creatorcontrib><creatorcontrib>Basha, Jahangeer</creatorcontrib><creatorcontrib>Prasad, Kaushal</creatorcontrib><creatorcontrib>Appasani, Sreekanth</creatorcontrib><creatorcontrib>Ashat, Munish</creatorcontrib><creatorcontrib>Vaiphei, Kim</creatorcontrib><creatorcontrib>Singh, Kartar</creatorcontrib><creatorcontrib>Kochhar, Rakesh</creatorcontrib><title>Utility of narrow band imaging in predicting histology in celiac disease</title><title>Indian journal of gastroenterology</title><addtitle>Indian J Gastroenterol</addtitle><description>Background
Narrow band imaging (NBI) with magnification better visualizes the duodenal microsurface and mucosal vascularity. NBI delineates villous atrophy better than conventional white light endoscopy.
Aims
This study was conducted to evaluate the diagnostic accuracy of narrow band imaging with magnification (NBI-ME) in celiac disease (CD).
Methods
In this prospective study, consecutive patients of suspected CD and controls were subjected to tissue transglutaminase antibody test and endoscopic evaluation initially with white light followed by NBI-ME, and biopsies were taken from duodenum. Duodenal villous patterns on NBI were interpreted as normal, blunted distorted, and absent. Severity of villous atrophy was reported according to the modified Marsh criteria.
Results
One hundred and twenty-two patients (mean age of 27.53 ± 13.37 years and a male to female ratio of 1:1.26) and 40 controls were studied. The sensitivity and specificity of NBI-ME in predicting villous atrophy were found to be 95.54% and 90%, respectively. The specificity and negative predictive value of NBI-ME in predicting villous atrophy amongst controls was 100% and 97.5%, respectively. Abnormal findings (blunted and absent villous patterns) combined with elevated transglutaminase antibody (> 5-fold) were found to have high accuracy in predicting villous atrophy.
Conclusion
NBI with magnification has high sensitivity and specificity in predicting villous atrophy in patients with celiac disease.</description><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><issn>0254-8860</issn><issn>0975-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EEqXwA6y8ZGOYsZ04WaKKl1SJTVlbbuwEV2lc7FSof49DWLOah-4dzT2E3CLcI4B6SMjLUjLgwABBAMMzsoBaFQwU4nnueSFZVZVwSa5S2sE012JBXj9G3_vxRENLBxNj-KZbM1jq96bzQ0f9QA_RWd-M0_Tp0xj60J2mfeN6bxpqfXImuWty0Zo-uZu_uiSb56fN6pWt31_eVo9r1gguR2ZAcKscF1XttlK1aKwVKEq5hYZjI-qW16AKg1WBFa9AYMudVaK0hYHWiCW5m88eYvg6ujTqvU_5k94MLhyT5pIrATLjyFI-S5sYUoqu1YeYY8WTRtATNT1T05ma_qWmMZvEbEpZPHQu6l04xiEn-s_1A169bt4</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Sinha, Saroj Kant</creator><creator>Berry, Neha</creator><creator>Muktesh, Gaurav</creator><creator>Siddappa, Pradeep</creator><creator>Basha, Jahangeer</creator><creator>Prasad, Kaushal</creator><creator>Appasani, Sreekanth</creator><creator>Ashat, Munish</creator><creator>Vaiphei, Kim</creator><creator>Singh, Kartar</creator><creator>Kochhar, Rakesh</creator><general>Springer India</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200801</creationdate><title>Utility of narrow band imaging in predicting histology in celiac disease</title><author>Sinha, Saroj Kant ; Berry, Neha ; Muktesh, Gaurav ; Siddappa, Pradeep ; Basha, Jahangeer ; Prasad, Kaushal ; Appasani, Sreekanth ; Ashat, Munish ; Vaiphei, Kim ; Singh, Kartar ; Kochhar, Rakesh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-a032d7e2389eb47f1add31364b0c21c39f29075a1851828031f2ed736d5a0fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sinha, Saroj Kant</creatorcontrib><creatorcontrib>Berry, Neha</creatorcontrib><creatorcontrib>Muktesh, Gaurav</creatorcontrib><creatorcontrib>Siddappa, Pradeep</creatorcontrib><creatorcontrib>Basha, Jahangeer</creatorcontrib><creatorcontrib>Prasad, Kaushal</creatorcontrib><creatorcontrib>Appasani, Sreekanth</creatorcontrib><creatorcontrib>Ashat, Munish</creatorcontrib><creatorcontrib>Vaiphei, Kim</creatorcontrib><creatorcontrib>Singh, Kartar</creatorcontrib><creatorcontrib>Kochhar, Rakesh</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sinha, Saroj Kant</au><au>Berry, Neha</au><au>Muktesh, Gaurav</au><au>Siddappa, Pradeep</au><au>Basha, Jahangeer</au><au>Prasad, Kaushal</au><au>Appasani, Sreekanth</au><au>Ashat, Munish</au><au>Vaiphei, Kim</au><au>Singh, Kartar</au><au>Kochhar, Rakesh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utility of narrow band imaging in predicting histology in celiac disease</atitle><jtitle>Indian journal of gastroenterology</jtitle><stitle>Indian J Gastroenterol</stitle><date>2020-08-01</date><risdate>2020</risdate><volume>39</volume><issue>4</issue><spage>370</spage><epage>376</epage><pages>370-376</pages><issn>0254-8860</issn><eissn>0975-0711</eissn><abstract>Background
Narrow band imaging (NBI) with magnification better visualizes the duodenal microsurface and mucosal vascularity. NBI delineates villous atrophy better than conventional white light endoscopy.
Aims
This study was conducted to evaluate the diagnostic accuracy of narrow band imaging with magnification (NBI-ME) in celiac disease (CD).
Methods
In this prospective study, consecutive patients of suspected CD and controls were subjected to tissue transglutaminase antibody test and endoscopic evaluation initially with white light followed by NBI-ME, and biopsies were taken from duodenum. Duodenal villous patterns on NBI were interpreted as normal, blunted distorted, and absent. Severity of villous atrophy was reported according to the modified Marsh criteria.
Results
One hundred and twenty-two patients (mean age of 27.53 ± 13.37 years and a male to female ratio of 1:1.26) and 40 controls were studied. The sensitivity and specificity of NBI-ME in predicting villous atrophy were found to be 95.54% and 90%, respectively. The specificity and negative predictive value of NBI-ME in predicting villous atrophy amongst controls was 100% and 97.5%, respectively. Abnormal findings (blunted and absent villous patterns) combined with elevated transglutaminase antibody (> 5-fold) were found to have high accuracy in predicting villous atrophy.
Conclusion
NBI with magnification has high sensitivity and specificity in predicting villous atrophy in patients with celiac disease.</abstract><cop>New Delhi</cop><pub>Springer India</pub><doi>10.1007/s12664-020-01030-1</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0254-8860 |
| ispartof | Indian journal of gastroenterology, 2020-08, Vol.39 (4), p.370-376 |
| issn | 0254-8860 0975-0711 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2427304126 |
| source | Springer Online Journals |
| subjects | Gastroenterology Hepatology Medicine Medicine & Public Health Original Article |
| title | Utility of narrow band imaging in predicting histology in celiac disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T18%3A37%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Utility%20of%20narrow%20band%20imaging%20in%20predicting%20histology%20in%20celiac%20disease&rft.jtitle=Indian%20journal%20of%20gastroenterology&rft.au=Sinha,%20Saroj%20Kant&rft.date=2020-08-01&rft.volume=39&rft.issue=4&rft.spage=370&rft.epage=376&rft.pages=370-376&rft.issn=0254-8860&rft.eissn=0975-0711&rft_id=info:doi/10.1007/s12664-020-01030-1&rft_dat=%3Cproquest_cross%3E2427304126%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2427304126&rft_id=info:pmid/&rfr_iscdi=true |