Material-Sparing and Expedited Development of a Tablet Formulation of Carbamazepine Glutaric Acid Cocrystal– a QbD Approach

Purpose To efficiently develop a tablet formulation of carbamazepine using a soluble cocrystal with excess coformer to maintain phase stability during dissolution. Methods The carbamazepine – glutaric acid cocrystal (CBZ-GLA, 1:1) and excess glutaric acid (GLA) were mixed with suitable tablet excipi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmaceutical research 2020-08, Vol.37 (8), p.153-153, Article 153
Hauptverfasser:	Yamashita, Hiroyuki, Sun, Changquan Calvin
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Carbamazepine Carbamazepine - chemistry Carbamazepine - pharmacology Cellulose - chemistry Crystallization Dissolution Drug Compounding Excipients - chemistry Glutarates - chemistry Glutarates - pharmacology Medical Law Pharmacology/Toxicology Pharmacy Phase Transition Powders Research Paper Silicon Dioxide - chemistry Solubility Tablets - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!