Functional dyspepsia in children: A study of pathophysiological factors
Background and Aim Functional dyspepsia (FD) is common in children, and treatment targeted towards the altered pathophysiology can improve outcome. We evaluated FD children for abnormality of gastric accommodation and emptying, psychological stressors (PS), Helicobacter pylori (HP) infection, and po...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2021-03, Vol.36 (3), p.680-686 |
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| creator | Shava, Upender Srivastava, Anshu Mathias, Amrita Kumar, Narvesh Yachha, Surender Kumar Gambhir, Sanjay Poddar, Ujjal |
| description | Background and Aim
Functional dyspepsia (FD) is common in children, and treatment targeted towards the altered pathophysiology can improve outcome. We evaluated FD children for abnormality of gastric accommodation and emptying, psychological stressors (PS), Helicobacter pylori (HP) infection, and post‐infectious FD.
Methods
Diagnosis of FD was based on ROME III criteria. Clinical evaluation including dyspeptic symptom scoring and assessment for PS was performed. Satiety drink test for gastric accommodation, gastroscopy with biopsy for HP infection, and solid meal gastric emptying were performed. Sixty‐seven healthy children were enrolled for assessing PS and satiety drink test.
Results
Fifty‐five FD children (33 boys, age 12 [6–18] years) with symptoms for 4 (2–48) months and dyspeptic score of 5 (1–13) were enrolled. PS were more common in FD than in controls (46/55 vs 9/67; P |
| doi_str_mv | 10.1111/jgh.15193 |
| format | Article |
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Functional dyspepsia (FD) is common in children, and treatment targeted towards the altered pathophysiology can improve outcome. We evaluated FD children for abnormality of gastric accommodation and emptying, psychological stressors (PS), Helicobacter pylori (HP) infection, and post‐infectious FD.
Methods
Diagnosis of FD was based on ROME III criteria. Clinical evaluation including dyspeptic symptom scoring and assessment for PS was performed. Satiety drink test for gastric accommodation, gastroscopy with biopsy for HP infection, and solid meal gastric emptying were performed. Sixty‐seven healthy children were enrolled for assessing PS and satiety drink test.
Results
Fifty‐five FD children (33 boys, age 12 [6–18] years) with symptoms for 4 (2–48) months and dyspeptic score of 5 (1–13) were enrolled. PS were more common in FD than in controls (46/55 vs 9/67; P < 0.001). Median satiety drink volume was 360 mL (180–1320 mL); no patients had satiety drink volume of < 5th centile of healthy children. The frequency (98% vs 85%; P = 0.01) and severity (65 [10–175] vs 50 [5–130]; P < 0.001) of postprandial symptoms were higher in FD than in controls. Of the postprandial symptoms, pain (20.3% vs 0%; P = 0.000) was present only in FD. Delayed gastric emptying was present in 6.5%, HP infection in 11%, and post‐infectious FD in 13% cases. Etiological factor was identified in 87% children, with 20% having multiple factors.
Conclusions
Abnormality of gastric sensorimotor function is seen in one‐fourth of FD cases. HP infection and post‐infectious FD are present in 11% and 13% cases, respectively.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.15193</identifier><identifier>PMID: 32710649</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Biopsy ; Children ; Dyspepsia ; Functional dyspepsia ; Gastric accommodation ; Gastric emptying ; Gastroscopy ; Infections ; Psychological stressors ; Satiety ; Sensorimotor system</subject><ispartof>Journal of gastroenterology and hepatology, 2021-03, Vol.36 (3), p.680-686</ispartof><rights>2020 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><rights>2020 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.</rights><rights>2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-8bad1ccd7fbbaccc9822d29d20111dbdc990697f723c9495e72a24845a6d86e3</citedby><cites>FETCH-LOGICAL-c3533-8bad1ccd7fbbaccc9822d29d20111dbdc990697f723c9495e72a24845a6d86e3</cites><orcidid>0000-0003-0902-4140 ; 0000-0001-5277-4401</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgh.15193$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgh.15193$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32710649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shava, Upender</creatorcontrib><creatorcontrib>Srivastava, Anshu</creatorcontrib><creatorcontrib>Mathias, Amrita</creatorcontrib><creatorcontrib>Kumar, Narvesh</creatorcontrib><creatorcontrib>Yachha, Surender Kumar</creatorcontrib><creatorcontrib>Gambhir, Sanjay</creatorcontrib><creatorcontrib>Poddar, Ujjal</creatorcontrib><title>Functional dyspepsia in children: A study of pathophysiological factors</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim
Functional dyspepsia (FD) is common in children, and treatment targeted towards the altered pathophysiology can improve outcome. We evaluated FD children for abnormality of gastric accommodation and emptying, psychological stressors (PS), Helicobacter pylori (HP) infection, and post‐infectious FD.
Methods
Diagnosis of FD was based on ROME III criteria. Clinical evaluation including dyspeptic symptom scoring and assessment for PS was performed. Satiety drink test for gastric accommodation, gastroscopy with biopsy for HP infection, and solid meal gastric emptying were performed. Sixty‐seven healthy children were enrolled for assessing PS and satiety drink test.
Results
Fifty‐five FD children (33 boys, age 12 [6–18] years) with symptoms for 4 (2–48) months and dyspeptic score of 5 (1–13) were enrolled. PS were more common in FD than in controls (46/55 vs 9/67; P < 0.001). Median satiety drink volume was 360 mL (180–1320 mL); no patients had satiety drink volume of < 5th centile of healthy children. The frequency (98% vs 85%; P = 0.01) and severity (65 [10–175] vs 50 [5–130]; P < 0.001) of postprandial symptoms were higher in FD than in controls. Of the postprandial symptoms, pain (20.3% vs 0%; P = 0.000) was present only in FD. Delayed gastric emptying was present in 6.5%, HP infection in 11%, and post‐infectious FD in 13% cases. Etiological factor was identified in 87% children, with 20% having multiple factors.
Conclusions
Abnormality of gastric sensorimotor function is seen in one‐fourth of FD cases. HP infection and post‐infectious FD are present in 11% and 13% cases, respectively.</description><subject>Biopsy</subject><subject>Children</subject><subject>Dyspepsia</subject><subject>Functional dyspepsia</subject><subject>Gastric accommodation</subject><subject>Gastric emptying</subject><subject>Gastroscopy</subject><subject>Infections</subject><subject>Psychological stressors</subject><subject>Satiety</subject><subject>Sensorimotor system</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10L1OwzAUBWALgWgpDLwAisQCQ1r_JY7ZqooWUCWW7pZjO62rNA5xIpS3xyWFAYm73OW7R7oHgFsEpyjMbL_dTVGCODkDY0QpjBGj6TkYwwwlMSeIj8CV93sIIYUsuQQjghmCKeVjsFp2lWqtq2QZ6d7XpvZWRraK1M6WujHVUzSPfNvpPnJFVMt25-pd760r3daqcFRI1brGX4OLQpbe3Jz2BGyWz5vFS7x-X70u5utYkYSQOMulRkppVuS5VErxDGONucYw_KFzrTiHKWcFw0RxyhPDsMQ0o4lMdZYaMgEPQ2zduI_O-FYcrFemLGVlXOcFppgRGMJwoPd_6N51TfgzqCSQLIX4qB4HpRrnfWMKUTf2IJteICiO5YpQrvguN9i7U2KXH4z-lT9tBjAbwKctTf9_knhbvQyRX2Zhgo8</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Shava, Upender</creator><creator>Srivastava, Anshu</creator><creator>Mathias, Amrita</creator><creator>Kumar, Narvesh</creator><creator>Yachha, Surender Kumar</creator><creator>Gambhir, Sanjay</creator><creator>Poddar, Ujjal</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0902-4140</orcidid><orcidid>https://orcid.org/0000-0001-5277-4401</orcidid></search><sort><creationdate>202103</creationdate><title>Functional dyspepsia in children: A study of pathophysiological factors</title><author>Shava, Upender ; Srivastava, Anshu ; Mathias, Amrita ; Kumar, Narvesh ; Yachha, Surender Kumar ; Gambhir, Sanjay ; Poddar, Ujjal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-8bad1ccd7fbbaccc9822d29d20111dbdc990697f723c9495e72a24845a6d86e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biopsy</topic><topic>Children</topic><topic>Dyspepsia</topic><topic>Functional dyspepsia</topic><topic>Gastric accommodation</topic><topic>Gastric emptying</topic><topic>Gastroscopy</topic><topic>Infections</topic><topic>Psychological stressors</topic><topic>Satiety</topic><topic>Sensorimotor system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shava, Upender</creatorcontrib><creatorcontrib>Srivastava, Anshu</creatorcontrib><creatorcontrib>Mathias, Amrita</creatorcontrib><creatorcontrib>Kumar, Narvesh</creatorcontrib><creatorcontrib>Yachha, Surender Kumar</creatorcontrib><creatorcontrib>Gambhir, Sanjay</creatorcontrib><creatorcontrib>Poddar, Ujjal</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shava, Upender</au><au>Srivastava, Anshu</au><au>Mathias, Amrita</au><au>Kumar, Narvesh</au><au>Yachha, Surender Kumar</au><au>Gambhir, Sanjay</au><au>Poddar, Ujjal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional dyspepsia in children: A study of pathophysiological factors</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2021-03</date><risdate>2021</risdate><volume>36</volume><issue>3</issue><spage>680</spage><epage>686</epage><pages>680-686</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim
Functional dyspepsia (FD) is common in children, and treatment targeted towards the altered pathophysiology can improve outcome. We evaluated FD children for abnormality of gastric accommodation and emptying, psychological stressors (PS), Helicobacter pylori (HP) infection, and post‐infectious FD.
Methods
Diagnosis of FD was based on ROME III criteria. Clinical evaluation including dyspeptic symptom scoring and assessment for PS was performed. Satiety drink test for gastric accommodation, gastroscopy with biopsy for HP infection, and solid meal gastric emptying were performed. Sixty‐seven healthy children were enrolled for assessing PS and satiety drink test.
Results
Fifty‐five FD children (33 boys, age 12 [6–18] years) with symptoms for 4 (2–48) months and dyspeptic score of 5 (1–13) were enrolled. PS were more common in FD than in controls (46/55 vs 9/67; P < 0.001). Median satiety drink volume was 360 mL (180–1320 mL); no patients had satiety drink volume of < 5th centile of healthy children. The frequency (98% vs 85%; P = 0.01) and severity (65 [10–175] vs 50 [5–130]; P < 0.001) of postprandial symptoms were higher in FD than in controls. Of the postprandial symptoms, pain (20.3% vs 0%; P = 0.000) was present only in FD. Delayed gastric emptying was present in 6.5%, HP infection in 11%, and post‐infectious FD in 13% cases. Etiological factor was identified in 87% children, with 20% having multiple factors.
Conclusions
Abnormality of gastric sensorimotor function is seen in one‐fourth of FD cases. HP infection and post‐infectious FD are present in 11% and 13% cases, respectively.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32710649</pmid><doi>10.1111/jgh.15193</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0902-4140</orcidid><orcidid>https://orcid.org/0000-0001-5277-4401</orcidid></addata></record> |
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| subjects | Biopsy Children Dyspepsia Functional dyspepsia Gastric accommodation Gastric emptying Gastroscopy Infections Psychological stressors Satiety Sensorimotor system |
| title | Functional dyspepsia in children: A study of pathophysiological factors |
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