Donor Cytomegalovirus Transmission Patterns in Solid Organ Transplant Recipients With Primary Infection
Abstract Background The epidemiology of single versus multiple cytomegalovirus (CMV) strain transmission from donor (D+) to seronegative solid organ transplant (SOT) recipients (R−) is uncertain, as is whether “relapsing” recipient infection represents changing strain predominance when multiple stra...
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| Veröffentlicht in: | The Journal of infectious diseases 2021-03, Vol.223 (5), p.827-837 |
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| creator | Hasing, Maria E Pang, Xiaoli L Mabilangan, Curtis Preiksaitis, Jutta K |
| description | Abstract
Background
The epidemiology of single versus multiple cytomegalovirus (CMV) strain transmission from donor (D+) to seronegative solid organ transplant (SOT) recipients (R−) is uncertain, as is whether “relapsing” recipient infection represents changing strain predominance when multiple strains are transmitted. Here we characterized CMV strain transmission patterns in D+/R− SOT recipients.
Methods
We studied pairs or groups of D+/R− SOT recipients who received organs from a common donor (group A) and recipients who experienced ≥2 waves of CMV DNAemia (group B). CMV in plasma was characterized by genotype-specific real-time PCR for genes gB and gH.
Results
Single concordant genotypes were identified in 12 of 18 recipient pairs/group sharing a common donor (group A); at least 6 of 18 (33%) donors transmitted > 1 strain. A single CMV strain was detected in 14 of 15 recipients in group B; only 1 recipient had coinfection. A shift in CMV strain predominance occurred after the first posttransplant year in at least 4 recipients with coinfection.
Conclusions
Using a common donor approach, we confirmed that multiple CMV strain transmission from donors to R− SOT recipients is not uncommon. D+/R− SOT recipients with CMV coinfection can undergo changes in strain predominance in late waves of CMV DNAemia.
Although multiple strain transmission by SOT donors is not uncommon, most D+/R− recipient recurrent CMV DNAemia was due to infection with the same single strain. In coinfected recipients, late CMV DNAemia waves frequently demonstrated CMV strain predominance shifts |
| doi_str_mv | 10.1093/infdis/jiaa450 |
| format | Article |
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Background
The epidemiology of single versus multiple cytomegalovirus (CMV) strain transmission from donor (D+) to seronegative solid organ transplant (SOT) recipients (R−) is uncertain, as is whether “relapsing” recipient infection represents changing strain predominance when multiple strains are transmitted. Here we characterized CMV strain transmission patterns in D+/R− SOT recipients.
Methods
We studied pairs or groups of D+/R− SOT recipients who received organs from a common donor (group A) and recipients who experienced ≥2 waves of CMV DNAemia (group B). CMV in plasma was characterized by genotype-specific real-time PCR for genes gB and gH.
Results
Single concordant genotypes were identified in 12 of 18 recipient pairs/group sharing a common donor (group A); at least 6 of 18 (33%) donors transmitted > 1 strain. A single CMV strain was detected in 14 of 15 recipients in group B; only 1 recipient had coinfection. A shift in CMV strain predominance occurred after the first posttransplant year in at least 4 recipients with coinfection.
Conclusions
Using a common donor approach, we confirmed that multiple CMV strain transmission from donors to R− SOT recipients is not uncommon. D+/R− SOT recipients with CMV coinfection can undergo changes in strain predominance in late waves of CMV DNAemia.
Although multiple strain transmission by SOT donors is not uncommon, most D+/R− recipient recurrent CMV DNAemia was due to infection with the same single strain. In coinfected recipients, late CMV DNAemia waves frequently demonstrated CMV strain predominance shifts</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiaa450</identifier><identifier>PMID: 32706857</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Blood & organ donations ; Coinfection - drug therapy ; Cytomegalovirus ; Cytomegalovirus - classification ; Cytomegalovirus Infections - epidemiology ; Cytomegalovirus Infections - transmission ; Disease transmission ; Donors ; Epidemiology ; Genotypes ; Humans ; Organ Transplantation - adverse effects ; Retrospective Studies ; Transplant Recipients</subject><ispartof>The Journal of infectious diseases, 2021-03, Vol.223 (5), p.827-837</ispartof><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-b7ecc0b83d2d86f93819595a549b13e409c359fe1c7a2d8a2db75bc599d8386b3</citedby><cites>FETCH-LOGICAL-c357t-b7ecc0b83d2d86f93819595a549b13e409c359fe1c7a2d8a2db75bc599d8386b3</cites><orcidid>0000-0002-4047-4476</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32706857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasing, Maria E</creatorcontrib><creatorcontrib>Pang, Xiaoli L</creatorcontrib><creatorcontrib>Mabilangan, Curtis</creatorcontrib><creatorcontrib>Preiksaitis, Jutta K</creatorcontrib><title>Donor Cytomegalovirus Transmission Patterns in Solid Organ Transplant Recipients With Primary Infection</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Abstract
Background
The epidemiology of single versus multiple cytomegalovirus (CMV) strain transmission from donor (D+) to seronegative solid organ transplant (SOT) recipients (R−) is uncertain, as is whether “relapsing” recipient infection represents changing strain predominance when multiple strains are transmitted. Here we characterized CMV strain transmission patterns in D+/R− SOT recipients.
Methods
We studied pairs or groups of D+/R− SOT recipients who received organs from a common donor (group A) and recipients who experienced ≥2 waves of CMV DNAemia (group B). CMV in plasma was characterized by genotype-specific real-time PCR for genes gB and gH.
Results
Single concordant genotypes were identified in 12 of 18 recipient pairs/group sharing a common donor (group A); at least 6 of 18 (33%) donors transmitted > 1 strain. A single CMV strain was detected in 14 of 15 recipients in group B; only 1 recipient had coinfection. A shift in CMV strain predominance occurred after the first posttransplant year in at least 4 recipients with coinfection.
Conclusions
Using a common donor approach, we confirmed that multiple CMV strain transmission from donors to R− SOT recipients is not uncommon. D+/R− SOT recipients with CMV coinfection can undergo changes in strain predominance in late waves of CMV DNAemia.
Although multiple strain transmission by SOT donors is not uncommon, most D+/R− recipient recurrent CMV DNAemia was due to infection with the same single strain. In coinfected recipients, late CMV DNAemia waves frequently demonstrated CMV strain predominance shifts</description><subject>Blood & organ donations</subject><subject>Coinfection - drug therapy</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus - classification</subject><subject>Cytomegalovirus Infections - epidemiology</subject><subject>Cytomegalovirus Infections - transmission</subject><subject>Disease transmission</subject><subject>Donors</subject><subject>Epidemiology</subject><subject>Genotypes</subject><subject>Humans</subject><subject>Organ Transplantation - adverse effects</subject><subject>Retrospective Studies</subject><subject>Transplant Recipients</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1PwyAYBnBiNG5-XD0aEi966AallHI08zMx2aIzHhtK6WTpoAI12X8vptODFw-Ey48n78sDwBlGE4w4mWrT1NpP11qIjKI9MMaUsCTPMdkHY4TSNMEF5yNw5P0aIZSRnB2CEUkZygvKxmB1Y411cLYNdqNWorWf2vUeLp0wfqO919bAhQhBOeOhNvDFtrqGc7cSZkBdK0yAz0rqTisTPHzT4R0unN4It4WPplEyxJATcNCI1qvT3X0MXu9ul7OH5Gl-_zi7fkokoSwkFVNSoqogdVoXecNJgTnlVNCMV5ioDPHoeKOwZCKKeCpGK0k5rwtS5BU5BpdDbufsR698KOMWUrVxSmV7X6ZZylJeYJRHevGHrm3vTJyuTGlO4jyUZ1FNBiWd9d6ppuyG3UqMyu8KyqGCcldBfHC-i-2rjap_-c-fR3A1ANt3_4V9ARrak5A</recordid><startdate>20210303</startdate><enddate>20210303</enddate><creator>Hasing, Maria E</creator><creator>Pang, Xiaoli L</creator><creator>Mabilangan, Curtis</creator><creator>Preiksaitis, Jutta K</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4047-4476</orcidid></search><sort><creationdate>20210303</creationdate><title>Donor Cytomegalovirus Transmission Patterns in Solid Organ Transplant Recipients With Primary Infection</title><author>Hasing, Maria E ; Pang, Xiaoli L ; Mabilangan, Curtis ; Preiksaitis, Jutta K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-b7ecc0b83d2d86f93819595a549b13e409c359fe1c7a2d8a2db75bc599d8386b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Blood & organ donations</topic><topic>Coinfection - drug therapy</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus - classification</topic><topic>Cytomegalovirus Infections - epidemiology</topic><topic>Cytomegalovirus Infections - transmission</topic><topic>Disease transmission</topic><topic>Donors</topic><topic>Epidemiology</topic><topic>Genotypes</topic><topic>Humans</topic><topic>Organ Transplantation - adverse effects</topic><topic>Retrospective Studies</topic><topic>Transplant Recipients</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasing, Maria E</creatorcontrib><creatorcontrib>Pang, Xiaoli L</creatorcontrib><creatorcontrib>Mabilangan, Curtis</creatorcontrib><creatorcontrib>Preiksaitis, Jutta K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasing, Maria E</au><au>Pang, Xiaoli L</au><au>Mabilangan, Curtis</au><au>Preiksaitis, Jutta K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Donor Cytomegalovirus Transmission Patterns in Solid Organ Transplant Recipients With Primary Infection</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2021-03-03</date><risdate>2021</risdate><volume>223</volume><issue>5</issue><spage>827</spage><epage>837</epage><pages>827-837</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Abstract
Background
The epidemiology of single versus multiple cytomegalovirus (CMV) strain transmission from donor (D+) to seronegative solid organ transplant (SOT) recipients (R−) is uncertain, as is whether “relapsing” recipient infection represents changing strain predominance when multiple strains are transmitted. Here we characterized CMV strain transmission patterns in D+/R− SOT recipients.
Methods
We studied pairs or groups of D+/R− SOT recipients who received organs from a common donor (group A) and recipients who experienced ≥2 waves of CMV DNAemia (group B). CMV in plasma was characterized by genotype-specific real-time PCR for genes gB and gH.
Results
Single concordant genotypes were identified in 12 of 18 recipient pairs/group sharing a common donor (group A); at least 6 of 18 (33%) donors transmitted > 1 strain. A single CMV strain was detected in 14 of 15 recipients in group B; only 1 recipient had coinfection. A shift in CMV strain predominance occurred after the first posttransplant year in at least 4 recipients with coinfection.
Conclusions
Using a common donor approach, we confirmed that multiple CMV strain transmission from donors to R− SOT recipients is not uncommon. D+/R− SOT recipients with CMV coinfection can undergo changes in strain predominance in late waves of CMV DNAemia.
Although multiple strain transmission by SOT donors is not uncommon, most D+/R− recipient recurrent CMV DNAemia was due to infection with the same single strain. In coinfected recipients, late CMV DNAemia waves frequently demonstrated CMV strain predominance shifts</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32706857</pmid><doi>10.1093/infdis/jiaa450</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4047-4476</orcidid></addata></record> |
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| ispartof | The Journal of infectious diseases, 2021-03, Vol.223 (5), p.827-837 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Blood & organ donations Coinfection - drug therapy Cytomegalovirus Cytomegalovirus - classification Cytomegalovirus Infections - epidemiology Cytomegalovirus Infections - transmission Disease transmission Donors Epidemiology Genotypes Humans Organ Transplantation - adverse effects Retrospective Studies Transplant Recipients |
| title | Donor Cytomegalovirus Transmission Patterns in Solid Organ Transplant Recipients With Primary Infection |
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