Alpha-1 antitrypsin governs alcohol-related liver disease in mice and humans

ObjectiveAlcohol-related liver disease (ALD) is a global healthcare problem with limited treatment options. Alpha-1 antitrypsin (AAT, encoded by SERPINA1) shows potent anti-inflammatory activities in many preclinical and clinical trials. In our study, we aimed to explore the role of AAT in ALD.Desig...

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Veröffentlicht in:	Gut 2021-03, Vol.70 (3), p.585-594
Hauptverfasser:	Grander, Christoph, Schaefer, Benedikt, Schwärzler, Julian, Grabherr, Felix, de Graaf, Dennis M, Enrich, Barbara, Oberhuber, Georg, Mayr, Lisa, Sangineto, Moris, Jaschke, Nikolai, Adolph, Timon E, Effenberger, Maria, Moschen, Alexander R, Dinarello, Charles A, Zoller, Heinz, Tilg, Herbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol ALCOHOLIC LIVER DISEASE alpha 1-Antitrypsin - genetics alpha 1-Antitrypsin - physiology Animals Cirrhosis Clinical medicine Clinical trials Cytokines Cytokines - metabolism Disease Models, Animal Ethanol Experiments Fatty liver Female Genotype Hepatitis Hepatology Humans Inflammation Laboratories Leukocytes (neutrophilic) LIVER CIRRHOSIS Liver diseases Liver Diseases, Alcoholic - genetics Liver Diseases, Alcoholic - metabolism Liver Diseases, Alcoholic - mortality Liver transplantation Male Medical records Mice Mice, Inbred C57BL Mice, Transgenic Middle Aged Neutrophil Infiltration - drug effects Pathogenesis Patients Proteins Regression analysis Steatosis Survival Analysis Transplants & implants Tumor necrosis factor-TNF
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