Predictors of the effects of smoking cessation on the endothelial function of conduit and digital vessels
Smoking predisposes individuals to endothelial dysfunction. Flow-mediated dilation (FMD) and reactive hyperemia peripheral artery tonometry (RH-PAT) are used to assess endothelial function. However, whether smoking cessation demonstrates comparable effects on endothelial function evaluated by FMD an...
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| Veröffentlicht in: | Hypertension research 2021-01, Vol.44 (1), p.63-70 |
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| creator | Fukumoto, Kazuo Takemoto, Yasuhiko Norioka, Naoki Takahashi, Kanae Namikawa, Hiroki Tochino, Yoshihiro Shintani, Ayumi Yoshiyama, Minoru Shuto, Taichi |
| description | Smoking predisposes individuals to endothelial dysfunction. Flow-mediated dilation (FMD) and reactive hyperemia peripheral artery tonometry (RH-PAT) are used to assess endothelial function. However, whether smoking cessation demonstrates comparable effects on endothelial function evaluated by FMD and RH-PAT remains unclear. Thus, we aimed to evaluate the effects of smoking cessation on endothelial function evaluated simultaneously by FMD and RH-PAT and clarify the factors associated with these effects. Fifty-eight consecutive current smokers (mean ± standard deviation; age, 64 ± 11 years) who visited our smoking cessation outpatient department and succeeded with smoking cessation were enrolled. Twenty-one continued smokers were enrolled as age- and sex-matched controls. Clinical variables, FMD, and natural logarithmic transformation of the reactive hyperemia index (Ln-RHI) were examined before and 20 weeks after treatment initiation. In 58 smokers who succeeded with smoking cessation, FMD significantly improved (3.80 ± 2.24 to 4.60 ± 2.55%; p = 0.013), whereas Ln-RHI did not (0.59 ± 0.28 to 0.66 ± 0.22; p = 0.092). Spearman's rank correlation coefficient between changes in FMD and Ln-RHI was -0.004, and the intraclass correlation coefficient for a two-way mixed effects model was |
| doi_str_mv | 10.1038/s41440-020-0516-z |
| format | Article |
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Flow-mediated dilation (FMD) and reactive hyperemia peripheral artery tonometry (RH-PAT) are used to assess endothelial function. However, whether smoking cessation demonstrates comparable effects on endothelial function evaluated by FMD and RH-PAT remains unclear. Thus, we aimed to evaluate the effects of smoking cessation on endothelial function evaluated simultaneously by FMD and RH-PAT and clarify the factors associated with these effects. Fifty-eight consecutive current smokers (mean ± standard deviation; age, 64 ± 11 years) who visited our smoking cessation outpatient department and succeeded with smoking cessation were enrolled. Twenty-one continued smokers were enrolled as age- and sex-matched controls. Clinical variables, FMD, and natural logarithmic transformation of the reactive hyperemia index (Ln-RHI) were examined before and 20 weeks after treatment initiation. In 58 smokers who succeeded with smoking cessation, FMD significantly improved (3.80 ± 2.24 to 4.60 ± 2.55%; p = 0.013), whereas Ln-RHI did not (0.59 ± 0.28 to 0.66 ± 0.22; p = 0.092). Spearman's rank correlation coefficient between changes in FMD and Ln-RHI was -0.004, and the intraclass correlation coefficient for a two-way mixed effects model was <0.001 (p = 0.499). In multivariate analysis, the presence of an increase in FMD was inversely correlated with the Brinkman index and changes in systolic blood pressure (SBP), whereas Ln-RHI was positively correlated with changes in SBP and inversely correlated with baseline body mass index. These factors may predict the varying effects of smoking cessation on the endothelial function of the conduit and digital vessels.</description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1038/s41440-020-0516-z</identifier><identifier>PMID: 32694770</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Aged ; Endothelium ; Endothelium, Vascular ; Humans ; Hyperemia ; Manometry ; Middle Aged ; Smoking ; Smoking Cessation ; Vasodilation ; Veins & arteries</subject><ispartof>Hypertension research, 2021-01, Vol.44 (1), p.63-70</ispartof><rights>The Japanese Society of Hypertension 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-f4538baf15e41b592a2b10748ff025045f8afd2eb016736e74378c0e2d5a24593</citedby><cites>FETCH-LOGICAL-c419t-f4538baf15e41b592a2b10748ff025045f8afd2eb016736e74378c0e2d5a24593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32694770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukumoto, Kazuo</creatorcontrib><creatorcontrib>Takemoto, Yasuhiko</creatorcontrib><creatorcontrib>Norioka, Naoki</creatorcontrib><creatorcontrib>Takahashi, Kanae</creatorcontrib><creatorcontrib>Namikawa, Hiroki</creatorcontrib><creatorcontrib>Tochino, Yoshihiro</creatorcontrib><creatorcontrib>Shintani, Ayumi</creatorcontrib><creatorcontrib>Yoshiyama, Minoru</creatorcontrib><creatorcontrib>Shuto, Taichi</creatorcontrib><title>Predictors of the effects of smoking cessation on the endothelial function of conduit and digital vessels</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><description>Smoking predisposes individuals to endothelial dysfunction. Flow-mediated dilation (FMD) and reactive hyperemia peripheral artery tonometry (RH-PAT) are used to assess endothelial function. However, whether smoking cessation demonstrates comparable effects on endothelial function evaluated by FMD and RH-PAT remains unclear. Thus, we aimed to evaluate the effects of smoking cessation on endothelial function evaluated simultaneously by FMD and RH-PAT and clarify the factors associated with these effects. Fifty-eight consecutive current smokers (mean ± standard deviation; age, 64 ± 11 years) who visited our smoking cessation outpatient department and succeeded with smoking cessation were enrolled. Twenty-one continued smokers were enrolled as age- and sex-matched controls. Clinical variables, FMD, and natural logarithmic transformation of the reactive hyperemia index (Ln-RHI) were examined before and 20 weeks after treatment initiation. In 58 smokers who succeeded with smoking cessation, FMD significantly improved (3.80 ± 2.24 to 4.60 ± 2.55%; p = 0.013), whereas Ln-RHI did not (0.59 ± 0.28 to 0.66 ± 0.22; p = 0.092). Spearman's rank correlation coefficient between changes in FMD and Ln-RHI was -0.004, and the intraclass correlation coefficient for a two-way mixed effects model was <0.001 (p = 0.499). In multivariate analysis, the presence of an increase in FMD was inversely correlated with the Brinkman index and changes in systolic blood pressure (SBP), whereas Ln-RHI was positively correlated with changes in SBP and inversely correlated with baseline body mass index. These factors may predict the varying effects of smoking cessation on the endothelial function of the conduit and digital vessels.</description><subject>Aged</subject><subject>Endothelium</subject><subject>Endothelium, Vascular</subject><subject>Humans</subject><subject>Hyperemia</subject><subject>Manometry</subject><subject>Middle Aged</subject><subject>Smoking</subject><subject>Smoking Cessation</subject><subject>Vasodilation</subject><subject>Veins & arteries</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkUtLxDAUhYMozjj6A9xIwI2bah43abMU8QWCLnQd0jQZo51mbFrB-fVmZtSFkHC5ud85XHIQOqbknBJeXSSgAKQgLF9BZbHaQVPKoSqAUdhFU6Lyo5JcTtBBSm-EsEoouo8mnEkFZUmmKDz1rgl2iH3C0ePh1WHnvbPDpk2L-B66ObYuJTOE2OF8NkzXxFzbYFrsx85uZx7b2DVjGLDpGtyEeRjy_DOLXZsO0Z43bXJHP3WGXm6un6_uiofH2_ury4fCAlVD4UHwqjaeCge0FooZVlNSQuU9YYKA8JXxDXM1obLk0pXAy8oSxxphGAjFZ-hs67vs48fo0qAXIVnXtqZzcUyaAZO0VBJoRk__oW9x7Lu8XaZKzgkoSTJFt5TtY0q983rZh4XpvzQlep2D3uagcw56nYNeZc3Jj_NYL1zzp_j9eP4NlxiDbQ</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Fukumoto, Kazuo</creator><creator>Takemoto, Yasuhiko</creator><creator>Norioka, Naoki</creator><creator>Takahashi, Kanae</creator><creator>Namikawa, Hiroki</creator><creator>Tochino, Yoshihiro</creator><creator>Shintani, Ayumi</creator><creator>Yoshiyama, Minoru</creator><creator>Shuto, Taichi</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20210101</creationdate><title>Predictors of the effects of smoking cessation on the endothelial function of conduit and digital vessels</title><author>Fukumoto, Kazuo ; 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Flow-mediated dilation (FMD) and reactive hyperemia peripheral artery tonometry (RH-PAT) are used to assess endothelial function. However, whether smoking cessation demonstrates comparable effects on endothelial function evaluated by FMD and RH-PAT remains unclear. Thus, we aimed to evaluate the effects of smoking cessation on endothelial function evaluated simultaneously by FMD and RH-PAT and clarify the factors associated with these effects. Fifty-eight consecutive current smokers (mean ± standard deviation; age, 64 ± 11 years) who visited our smoking cessation outpatient department and succeeded with smoking cessation were enrolled. Twenty-one continued smokers were enrolled as age- and sex-matched controls. Clinical variables, FMD, and natural logarithmic transformation of the reactive hyperemia index (Ln-RHI) were examined before and 20 weeks after treatment initiation. In 58 smokers who succeeded with smoking cessation, FMD significantly improved (3.80 ± 2.24 to 4.60 ± 2.55%; p = 0.013), whereas Ln-RHI did not (0.59 ± 0.28 to 0.66 ± 0.22; p = 0.092). Spearman's rank correlation coefficient between changes in FMD and Ln-RHI was -0.004, and the intraclass correlation coefficient for a two-way mixed effects model was <0.001 (p = 0.499). In multivariate analysis, the presence of an increase in FMD was inversely correlated with the Brinkman index and changes in systolic blood pressure (SBP), whereas Ln-RHI was positively correlated with changes in SBP and inversely correlated with baseline body mass index. These factors may predict the varying effects of smoking cessation on the endothelial function of the conduit and digital vessels.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>32694770</pmid><doi>10.1038/s41440-020-0516-z</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Endothelium Endothelium, Vascular Humans Hyperemia Manometry Middle Aged Smoking Smoking Cessation Vasodilation Veins & arteries |
| title | Predictors of the effects of smoking cessation on the endothelial function of conduit and digital vessels |
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