Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities

Cholesterol metabolism produces essential membrane components as well as metabolites with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell-extrinsic cues reprogram cholesterol metabolism and consequently promote tumourigenesis. Cholesterol-derived metabolite...

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Veröffentlicht in:	Nature metabolism 2020-02, Vol.2 (2), p.132-141
Hauptverfasser:	Huang, Binlu, Song, Bao-liang, Xu, Chenqi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/580 631/45/287/1197 631/67/2327 631/67/327 Biomedical and Life Sciences Cellular Reprogramming Cholesterol - biosynthesis Cholesterol - metabolism Endoplasmic Reticulum Stress Humans Life Sciences Neoplasms - metabolism Neoplasms - pathology Neoplasms - therapy Review Article Tumor Microenvironment
Online-Zugang:	Volltext
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