Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities
Cholesterol metabolism produces essential membrane components as well as metabolites with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell-extrinsic cues reprogram cholesterol metabolism and consequently promote tumourigenesis. Cholesterol-derived metabolite...
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| Veröffentlicht in: | Nature metabolism 2020-02, Vol.2 (2), p.132-141 |
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| creator | Huang, Binlu Song, Bao-liang Xu, Chenqi |
| description | Cholesterol metabolism produces essential membrane components as well as metabolites with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell-extrinsic cues reprogram cholesterol metabolism and consequently promote tumourigenesis. Cholesterol-derived metabolites play complex roles in supporting cancer progression and suppressing immune responses. Preclinical and clinical studies have shown that manipulating cholesterol metabolism inhibits tumour growth, reshapes the immunological landscape and reinvigorates anti-tumour immunity. Here, we review cholesterol metabolism in cancer cells, its role in cancer progression and the mechanisms through which cholesterol metabolites affect immune cells in the tumour microenvironment. We also discuss therapeutic strategies aimed at interfering with cholesterol metabolism, and how the combination of such approaches with existing anti-cancer therapies can have synergistic effects, thus offering new therapeutic opportunities.
Xu and colleagues provide a comprehensive overview of cholesterol metabolism in cancer cells and its effects on immune cells of the tumour microenvironment, highlighting its effects on cancer growth as well as opportunities for therapeutic intervention. |
| doi_str_mv | 10.1038/s42255-020-0174-0 |
| format | Article |
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Xu and colleagues provide a comprehensive overview of cholesterol metabolism in cancer cells and its effects on immune cells of the tumour microenvironment, highlighting its effects on cancer growth as well as opportunities for therapeutic intervention.</description><subject>631/250/580</subject><subject>631/45/287/1197</subject><subject>631/67/2327</subject><subject>631/67/327</subject><subject>Biomedical and Life Sciences</subject><subject>Cellular Reprogramming</subject><subject>Cholesterol - biosynthesis</subject><subject>Cholesterol - metabolism</subject><subject>Endoplasmic Reticulum Stress</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - therapy</subject><subject>Review Article</subject><subject>Tumor Microenvironment</subject><issn>2522-5812</issn><issn>2522-5812</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EolXpD2BBGVkC54vjJGyo4lOVWGC2HOdCUyVxsJOBf4-rAGJiutP5uVfnh7FzDlcckvzaC8Q0jQEhBp6JGI7YElPEOM05Hv_pF2zt_R4AkHPBsThliwRlIWQBS_a82dmW_EjOtlFHoy5t2_guavrI6N6QuwlTs9N9GPpI91U07sjpgaaxMZEdBuvGqW_GhvwZO6l162n9XVfs7f7udfMYb18enja329gIDmNsEk08B8yqXJIo81qW0pSyzlKdIEgtskrmUsqEF6koBAWCdAYgswpqkaTJil3OuYOzH1O4XXWNN9S2uic7eYUCJc8KiRBQPqPGWe8d1WpwTafdp-KgDhbVbFEFi-pgUR12Lr7jp7Kj6nfjx1kAcAZ8eOrfyam9nVwfvvxP6hfZOHyE</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Huang, Binlu</creator><creator>Song, Bao-liang</creator><creator>Xu, Chenqi</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6397-5935</orcidid><orcidid>https://orcid.org/0000-0002-4968-6782</orcidid></search><sort><creationdate>20200201</creationdate><title>Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities</title><author>Huang, Binlu ; Song, Bao-liang ; Xu, Chenqi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-c3ae18027d86e4b8f6b6cb6f75a3206a47d686663195494eb8fea70067d0f4353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>631/250/580</topic><topic>631/45/287/1197</topic><topic>631/67/2327</topic><topic>631/67/327</topic><topic>Biomedical and Life Sciences</topic><topic>Cellular Reprogramming</topic><topic>Cholesterol - biosynthesis</topic><topic>Cholesterol - metabolism</topic><topic>Endoplasmic Reticulum Stress</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - therapy</topic><topic>Review Article</topic><topic>Tumor Microenvironment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Binlu</creatorcontrib><creatorcontrib>Song, Bao-liang</creatorcontrib><creatorcontrib>Xu, Chenqi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Binlu</au><au>Song, Bao-liang</au><au>Xu, Chenqi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities</atitle><jtitle>Nature metabolism</jtitle><stitle>Nat Metab</stitle><addtitle>Nat Metab</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>2</volume><issue>2</issue><spage>132</spage><epage>141</epage><pages>132-141</pages><issn>2522-5812</issn><eissn>2522-5812</eissn><abstract>Cholesterol metabolism produces essential membrane components as well as metabolites with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell-extrinsic cues reprogram cholesterol metabolism and consequently promote tumourigenesis. Cholesterol-derived metabolites play complex roles in supporting cancer progression and suppressing immune responses. Preclinical and clinical studies have shown that manipulating cholesterol metabolism inhibits tumour growth, reshapes the immunological landscape and reinvigorates anti-tumour immunity. Here, we review cholesterol metabolism in cancer cells, its role in cancer progression and the mechanisms through which cholesterol metabolites affect immune cells in the tumour microenvironment. We also discuss therapeutic strategies aimed at interfering with cholesterol metabolism, and how the combination of such approaches with existing anti-cancer therapies can have synergistic effects, thus offering new therapeutic opportunities.
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| subjects | 631/250/580 631/45/287/1197 631/67/2327 631/67/327 Biomedical and Life Sciences Cellular Reprogramming Cholesterol - biosynthesis Cholesterol - metabolism Endoplasmic Reticulum Stress Humans Life Sciences Neoplasms - metabolism Neoplasms - pathology Neoplasms - therapy Review Article Tumor Microenvironment |
| title | Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities |
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