Synergistic substrate cofeeding stimulates reductive metabolism

Advanced bioproduct synthesis via reductive metabolism requires coordinating carbons, ATP and reducing agents, which are generated with varying efficiencies depending on metabolic pathways. Substrate mixtures with direct access to multiple pathways may optimally satisfy these biosynthetic requiremen...

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Veröffentlicht in:	Nature metabolism 2019-06, Vol.1 (6), p.643-651
Hauptverfasser:	Park, Junyoung O., Liu, Nian, Holinski, Kara M., Emerson, David F., Qiao, Kangjian, Woolston, Benjamin M., Xu, Jingyang, Lazar, Zbigniew, Islam, M. Ahsanul, Vidoudez, Charles, Girguis, Peter R., Stephanopoulos, Gregory
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/320 631/553/318 82/58 Adenosine Triphosphate - metabolism Biomedical and Life Sciences Citric Acid Cycle - physiology Glucose - metabolism Life Sciences Moorella - metabolism NADP - metabolism Oxidation-Reduction Pentose Phosphate Pathway - physiology Yarrowia - metabolism
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