Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance

Stress granules (SGs) are membrane-less ribonucleoprotein condensates that form in response to various stress stimuli via phase separation. SGs act as a protective mechanism to cope with acute stress, but persistent SGs have cytotoxic effects that are associated with several age-related diseases. He...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular cell 2020-08, Vol.79 (4), p.645-659.e9
Hauptverfasser:	Lee, Anna K., Klein, Jonathon, Fon Tacer, Klementina, Lord, Tessa, Oatley, Melissa J., Oatley, Jon M., Porter, Shaina N., Pruett-Miller, Shondra M., Tikhonova, Elena B., Karamyshev, Andrey L., Wang, Yong-Dong, Yang, Peiguo, Korff, Ane, Kim, Hong Joo, Taylor, J. Paul, Potts, Patrick Ryan
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer cancer-testis antigen DDX5 G3BP MAGE-B2 RNA binding protein spermatogonial stem cells stress granule testis translation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!