Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel

The nature and extent of mitochondrial DNA variation in a population and how it affects traits is poorly understood. Here we resequence the mitochondrial genomes of 169 Drosophila Genetic Reference Panel lines, identifying 231 variants that stratify along 12 mitochondrial haplotypes. We identify 1,8...

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Veröffentlicht in:	Nature metabolism 2019-12, Vol.1 (12), p.1226-1242
Hauptverfasser:	Bevers, Roel P. J., Litovchenko, Maria, Kapopoulou, Adamandia, Braman, Virginie S., Robinson, Matthew R., Auwerx, Johan, Hollis, Brian, Deplancke, Bart
Format:	Artikel
Sprache:	eng
Schlagworte:	38/23 45/43 631/1647/334/1582/715 631/208/205 631/443/319/1488 631/443/319/333 Alleles Animals Biomedical and Life Sciences Cell Nucleus - genetics Chromosome Mapping DNA, Mitochondrial - genetics Drosophila - genetics Eating Genome, Mitochondrial Genotype Haplotypes - genetics High-Throughput Nucleotide Sequencing Life Sciences Male Metabolism - genetics Mitochondria - genetics Mitochondria - metabolism Oxygen Consumption - genetics Phenotype Reference Standards
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