Recent synthetic strategies toward the synthesis of spirocyclic compounds comprising six-membered carbocyclic/heterocyclic ring systems
Spirocyclic compounds fascinate the synthetic chemists due to their privileged ring system and efficacy in drug discovery. Many natural compounds comprise spirocyclic moiety in their skeleton and are effective in pharmaceutical industry. Over the years, many synthetic methodologies have been establi...
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| Veröffentlicht in: | Molecular diversity 2021-11, Vol.25 (4), p.2487-2532 |
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| container_title | Molecular diversity |
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| creator | Babar, Kashaf Zahoor, Ameer Fawad Ahmad, Sajjad Akhtar, Rabia |
| description | Spirocyclic compounds fascinate the synthetic chemists due to their privileged ring system and efficacy in drug discovery. Many natural compounds comprise spirocyclic moiety in their skeleton and are effective in pharmaceutical industry. Over the years, many synthetic methodologies have been established for the construction of spirocyclic compounds. In this review, recent synthetic approaches to accessing various spirocompounds comprising six-membered carbocycles/heterocycles have been summarized.
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| doi_str_mv | 10.1007/s11030-020-10126-x |
| format | Article |
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| identifier | ISSN: 1381-1991 |
| ispartof | Molecular diversity, 2021-11, Vol.25 (4), p.2487-2532 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Biochemistry Biomedical and Life Sciences Cancer Chemistry Techniques, Synthetic Comprehensive Review Cytotoxicity Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Life Sciences Organic Chemistry Pharmaceutical industry Pharmacy Polymer Sciences Solvents Spiro Compounds - chemical synthesis Spiro Compounds - chemistry |
| title | Recent synthetic strategies toward the synthesis of spirocyclic compounds comprising six-membered carbocyclic/heterocyclic ring systems |
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