Ambient Moisture Accelerates Hydroamination Reactions of Vinylarenes with Alkali‐Metal Amides under Air

A straightforward alkali‐metal‐mediated hydroamination of styrenes using biorenewable 2‐methyltetrahydrofuran as a solvent is reported. Refuting the conventional wisdom of the incompatibility of organolithium reagents with air and moisture, shown here is that the presence of moisture is key in favor...

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Veröffentlicht in:	Angewandte Chemie International Edition 2020-10, Vol.59 (43), p.19021-19026
Hauptverfasser:	Mulks, Florian F., Bole, Leonie J., Davin, Laia, Hernán‐Gómez, Alberto, Kennedy, Alan, García‐Álvarez, Joaquín, Hevia, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkali metals Amides Catalysts hydroamination Incompatibility Inert atmospheres lithium Moisture Reagents solvent effects Styrenes synthetic methods
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