Generation of mice with hepatocyte-specific conditional deletion of sphingosine kinase 1

SphK1 gene has different roles in various types of cells in liver diseases, but most studies are based on global knockout mice, which hampers the study on the cellular and molecular mechanisms of SphK1. In order to further study the role of SphK1 in liver, SphK1 conditional knockout mice were constr...

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Veröffentlicht in:	Transgenic research 2020-08, Vol.29 (4), p.419-428
Hauptverfasser:	Yu, Jinfeng, Dong, Jiale, Chen, Kangdi, Ding, Yaping, Yang, Zhicheng, Lan, Tian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Biomedical and Life Sciences Biomedical Engineering/Biotechnology Enzyme-linked immunosorbent assay Fluorescence in situ hybridization Gene deletion Genetic Engineering Genotypes Hepatocytes Kinases Life Sciences Liver diseases Molecular Medicine Molecular modelling mRNA Original Paper Plant Genetics and Genomics Rodents Serology Sphingosine kinase Transgenics Western blotting
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