Taurine prevents high‐fat diet‐induced‐hepatic steatosis in rats by direct inhibition of hepatic sterol regulatory element‐binding proteins and activation of AMPK

This study investigated if the protective effect of taurine against high fat diet‐induced hepatic steatosis involves modulating the hepatic activity of 5' AMP‐activated protein kinase (AMPK) and levels/activity of the sterol regulatory element‐binding proteins‐1/2 (SREBP1/2). Rats were divided...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2021-01, Vol.48 (1), p.72-85
Hauptverfasser:	Morsy, Mohamed Darwesh, Aboonq, Moutasem Salih, ALsleem, Mohammed Abadi, Abusham, Abdalla Abdelrahim
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP AMPK Antioxidants Binding Carnitine Carnitine palmitoyltransferase Cholesterol Diet Fatty acids Fatty liver Fatty-acid synthase Food intake Glutathione hepatic steatosis HFD High fat diet Insulin Kinases Lipids mRNA Oxidation Palmitoyltransferase Peroxisome proliferator-activated receptors Protein kinase Proteins rats Reductases Regulatory sequences Rodents SREBPs Steatosis Sterol regulatory element-binding protein Sterols Superoxide dismutase Taurine Triglycerides
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