Prospective associations of sleep apnea, periodic limb movements, and plasma fibrinogen level
Purpose Our previous cross-sectional study showed that periodic limb movements during sleep (PLMS) were frequently found in patients with obstructive sleep apnea (OSA) and that both OSA and PLMS were associated with higher plasma fibrinogen levels. We explored the longitudinal relationships among th...
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| Veröffentlicht in: | Sleep & breathing 2021-06, Vol.25 (2), p.617-625 |
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| creator | Murase, Kimihiko Azuma, Masanori Tachikawa, Ryo Minami, Takuma Matsumoto, Takeshi Hamada, Satoshi Nakatsuka, Yoshinari Takahashi, Naomi Takeyama, Hirofumi Tanizawa, Kiminobu Oga, Toru Handa, Tomohiro Hirai, Toyohiro Chin, Kazuo |
| description | Purpose
Our previous cross-sectional study showed that periodic limb movements during sleep (PLMS) were frequently found in patients with obstructive sleep apnea (OSA) and that both OSA and PLMS were associated with higher plasma fibrinogen levels. We explored the longitudinal relationships among these factors.
Methods
Plasma fibrinogen levels were measured in 333 consecutive patients who underwent polysomnography to diagnose OSA. Patients who initiated continuous positive airway pressure (CPAP) underwent follow-up polysomnography after 3 months of CPAP use. They were categorized into groups with good or poor adherence (% days with ≥ 4 h/night of CPAP use ≥ 70% or |
| doi_str_mv | 10.1007/s11325-020-02147-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2425898775</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2425898775</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-ed0077ef9fdcc9ab1b3f404e2eeb98c66ac284efdf2d2c22ea0562523b3cfe013</originalsourceid><addsrcrecordid>eNp9kEFrFTEQx4NY2lr7BTxIwEsP3TqZTd5ujlKsFgp60KOEbHZSUnaTNdn3wG9vXl9V8NBDJoH55T_Jj7E3Aq4EQPe-CNGiagChLiG7Rr1gp0IhNqID_fLxDI1WAk_Yq1IeAITstThmJy1utEDQp-zH15zKQm4NO-K2lOSCXUOKhSfPy0S0cLtEspd8oRzSGByfwjzwOe1opriWS27jyJfJltlyH4YcYrqnyCfa0fSaHXk7FTp_2s_Y95uP364_N3dfPt1ef7hrnJRibWis3-nIaz86p-0ghtZLkIREg-7dZmMd9pL86HFEh0gW1AYVtkPrPIFoz9jFIXfJ6eeWymrmUBxNk42UtsWgRNXrvutURd_9hz6kbY71dQaVBIB9rRQeKFf1lEzeLDnMNv8yAsxevjnIN1W-eZRv9tFvn6K3w0zj3yt_bFegPQCltuI95X-zn4n9DRdtkFE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2540002540</pqid></control><display><type>article</type><title>Prospective associations of sleep apnea, periodic limb movements, and plasma fibrinogen level</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Murase, Kimihiko ; Azuma, Masanori ; Tachikawa, Ryo ; Minami, Takuma ; Matsumoto, Takeshi ; Hamada, Satoshi ; Nakatsuka, Yoshinari ; Takahashi, Naomi ; Takeyama, Hirofumi ; Tanizawa, Kiminobu ; Oga, Toru ; Handa, Tomohiro ; Hirai, Toyohiro ; Chin, Kazuo</creator><creatorcontrib>Murase, Kimihiko ; Azuma, Masanori ; Tachikawa, Ryo ; Minami, Takuma ; Matsumoto, Takeshi ; Hamada, Satoshi ; Nakatsuka, Yoshinari ; Takahashi, Naomi ; Takeyama, Hirofumi ; Tanizawa, Kiminobu ; Oga, Toru ; Handa, Tomohiro ; Hirai, Toyohiro ; Chin, Kazuo</creatorcontrib><description>Purpose
Our previous cross-sectional study showed that periodic limb movements during sleep (PLMS) were frequently found in patients with obstructive sleep apnea (OSA) and that both OSA and PLMS were associated with higher plasma fibrinogen levels. We explored the longitudinal relationships among these factors.
Methods
Plasma fibrinogen levels were measured in 333 consecutive patients who underwent polysomnography to diagnose OSA. Patients who initiated continuous positive airway pressure (CPAP) underwent follow-up polysomnography after 3 months of CPAP use. They were categorized into groups with good or poor adherence (% days with ≥ 4 h/night of CPAP use ≥ 70% or < 70%, respectively). Changes in sleep parameters and plasma fibrinogen levels during the treatment period were compared between these groups.
Results
The cross-sectional analysis of all reviewed 333 patients indicated that fibrinogen levels were associated with the severities of OSA and PLMS. The 60 patients (27 good and 33 poor adherence) who underwent follow-up polysomnography were included in the longitudinal analysis. The median (interquartile range) periodic limb movement index did not change significantly from CPAP titration to the 3-month follow-up (good adherence: 10.5 (0–23.8) to 10.8 (0–70.2) events/h,
p
= 0.21; poor adherence: 1.2 (0–14.3) to 0.8 (0–15.7) events/h,
p
= 0.67). However, the plasma fibrinogen level significantly decreased only in the good adherence group (good adherence: baseline 275 ± 46 to follow-up 255 ± 47 mg/dl,
p
< 0.01; poor adherence: 277 ± 52 to 284 ± 70 mg/dl,
p
= 0.48).
Conclusions
These results did not support a longitudinal association between PLMS and OSA. However, good adherence to CPAP could reduce plasma fibrinogen levels, thus ameliorating elevations in plasma fibrinogen as a risk factor for future cardiovascular events.</description><identifier>ISSN: 1520-9512</identifier><identifier>EISSN: 1522-1709</identifier><identifier>DOI: 10.1007/s11325-020-02147-5</identifier><identifier>PMID: 32691209</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Aged ; Apnea ; Cardiovascular diseases ; Continuous positive airway pressure ; Continuous Positive Airway Pressure - statistics & numerical data ; Cross-Sectional Studies ; Dentistry ; Female ; Fibrinogen ; Fibrinogen - analysis ; Humans ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neurology ; Otorhinolaryngology ; Patient compliance ; Pediatrics ; Physical growth ; Plasma ; Pneumology/Respiratory System ; Polysomnography ; Prospective Studies ; Restless Legs Syndrome - blood ; Restless Legs Syndrome - epidemiology ; Risk factors ; Sleep ; Sleep apnea ; Sleep Apnea, Obstructive - blood ; Sleep Apnea, Obstructive - epidemiology ; Sleep Apnea, Obstructive - therapy ; Sleep Breathing Physiology and Disorders • Original Article ; Sleep disorders ; Titration</subject><ispartof>Sleep & breathing, 2021-06, Vol.25 (2), p.617-625</ispartof><rights>Springer Nature Switzerland AG 2020</rights><rights>Springer Nature Switzerland AG 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-ed0077ef9fdcc9ab1b3f404e2eeb98c66ac284efdf2d2c22ea0562523b3cfe013</citedby><cites>FETCH-LOGICAL-c441t-ed0077ef9fdcc9ab1b3f404e2eeb98c66ac284efdf2d2c22ea0562523b3cfe013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11325-020-02147-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11325-020-02147-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32691209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murase, Kimihiko</creatorcontrib><creatorcontrib>Azuma, Masanori</creatorcontrib><creatorcontrib>Tachikawa, Ryo</creatorcontrib><creatorcontrib>Minami, Takuma</creatorcontrib><creatorcontrib>Matsumoto, Takeshi</creatorcontrib><creatorcontrib>Hamada, Satoshi</creatorcontrib><creatorcontrib>Nakatsuka, Yoshinari</creatorcontrib><creatorcontrib>Takahashi, Naomi</creatorcontrib><creatorcontrib>Takeyama, Hirofumi</creatorcontrib><creatorcontrib>Tanizawa, Kiminobu</creatorcontrib><creatorcontrib>Oga, Toru</creatorcontrib><creatorcontrib>Handa, Tomohiro</creatorcontrib><creatorcontrib>Hirai, Toyohiro</creatorcontrib><creatorcontrib>Chin, Kazuo</creatorcontrib><title>Prospective associations of sleep apnea, periodic limb movements, and plasma fibrinogen level</title><title>Sleep & breathing</title><addtitle>Sleep Breath</addtitle><addtitle>Sleep Breath</addtitle><description>Purpose
Our previous cross-sectional study showed that periodic limb movements during sleep (PLMS) were frequently found in patients with obstructive sleep apnea (OSA) and that both OSA and PLMS were associated with higher plasma fibrinogen levels. We explored the longitudinal relationships among these factors.
Methods
Plasma fibrinogen levels were measured in 333 consecutive patients who underwent polysomnography to diagnose OSA. Patients who initiated continuous positive airway pressure (CPAP) underwent follow-up polysomnography after 3 months of CPAP use. They were categorized into groups with good or poor adherence (% days with ≥ 4 h/night of CPAP use ≥ 70% or < 70%, respectively). Changes in sleep parameters and plasma fibrinogen levels during the treatment period were compared between these groups.
Results
The cross-sectional analysis of all reviewed 333 patients indicated that fibrinogen levels were associated with the severities of OSA and PLMS. The 60 patients (27 good and 33 poor adherence) who underwent follow-up polysomnography were included in the longitudinal analysis. The median (interquartile range) periodic limb movement index did not change significantly from CPAP titration to the 3-month follow-up (good adherence: 10.5 (0–23.8) to 10.8 (0–70.2) events/h,
p
= 0.21; poor adherence: 1.2 (0–14.3) to 0.8 (0–15.7) events/h,
p
= 0.67). However, the plasma fibrinogen level significantly decreased only in the good adherence group (good adherence: baseline 275 ± 46 to follow-up 255 ± 47 mg/dl,
p
< 0.01; poor adherence: 277 ± 52 to 284 ± 70 mg/dl,
p
= 0.48).
Conclusions
These results did not support a longitudinal association between PLMS and OSA. However, good adherence to CPAP could reduce plasma fibrinogen levels, thus ameliorating elevations in plasma fibrinogen as a risk factor for future cardiovascular events.</description><subject>Adult</subject><subject>Aged</subject><subject>Apnea</subject><subject>Cardiovascular diseases</subject><subject>Continuous positive airway pressure</subject><subject>Continuous Positive Airway Pressure - statistics & numerical data</subject><subject>Cross-Sectional Studies</subject><subject>Dentistry</subject><subject>Female</subject><subject>Fibrinogen</subject><subject>Fibrinogen - analysis</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Otorhinolaryngology</subject><subject>Patient compliance</subject><subject>Pediatrics</subject><subject>Physical growth</subject><subject>Plasma</subject><subject>Pneumology/Respiratory System</subject><subject>Polysomnography</subject><subject>Prospective Studies</subject><subject>Restless Legs Syndrome - blood</subject><subject>Restless Legs Syndrome - epidemiology</subject><subject>Risk factors</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - blood</subject><subject>Sleep Apnea, Obstructive - epidemiology</subject><subject>Sleep Apnea, Obstructive - therapy</subject><subject>Sleep Breathing Physiology and Disorders • Original Article</subject><subject>Sleep disorders</subject><subject>Titration</subject><issn>1520-9512</issn><issn>1522-1709</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kEFrFTEQx4NY2lr7BTxIwEsP3TqZTd5ujlKsFgp60KOEbHZSUnaTNdn3wG9vXl9V8NBDJoH55T_Jj7E3Aq4EQPe-CNGiagChLiG7Rr1gp0IhNqID_fLxDI1WAk_Yq1IeAITstThmJy1utEDQp-zH15zKQm4NO-K2lOSCXUOKhSfPy0S0cLtEspd8oRzSGByfwjzwOe1opriWS27jyJfJltlyH4YcYrqnyCfa0fSaHXk7FTp_2s_Y95uP364_N3dfPt1ef7hrnJRibWis3-nIaz86p-0ghtZLkIREg-7dZmMd9pL86HFEh0gW1AYVtkPrPIFoz9jFIXfJ6eeWymrmUBxNk42UtsWgRNXrvutURd_9hz6kbY71dQaVBIB9rRQeKFf1lEzeLDnMNv8yAsxevjnIN1W-eZRv9tFvn6K3w0zj3yt_bFegPQCltuI95X-zn4n9DRdtkFE</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Murase, Kimihiko</creator><creator>Azuma, Masanori</creator><creator>Tachikawa, Ryo</creator><creator>Minami, Takuma</creator><creator>Matsumoto, Takeshi</creator><creator>Hamada, Satoshi</creator><creator>Nakatsuka, Yoshinari</creator><creator>Takahashi, Naomi</creator><creator>Takeyama, Hirofumi</creator><creator>Tanizawa, Kiminobu</creator><creator>Oga, Toru</creator><creator>Handa, Tomohiro</creator><creator>Hirai, Toyohiro</creator><creator>Chin, Kazuo</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2R</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20210601</creationdate><title>Prospective associations of sleep apnea, periodic limb movements, and plasma fibrinogen level</title><author>Murase, Kimihiko ; Azuma, Masanori ; Tachikawa, Ryo ; Minami, Takuma ; Matsumoto, Takeshi ; Hamada, Satoshi ; Nakatsuka, Yoshinari ; Takahashi, Naomi ; Takeyama, Hirofumi ; Tanizawa, Kiminobu ; Oga, Toru ; Handa, Tomohiro ; Hirai, Toyohiro ; Chin, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-ed0077ef9fdcc9ab1b3f404e2eeb98c66ac284efdf2d2c22ea0562523b3cfe013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Apnea</topic><topic>Cardiovascular diseases</topic><topic>Continuous positive airway pressure</topic><topic>Continuous Positive Airway Pressure - statistics & numerical data</topic><topic>Cross-Sectional Studies</topic><topic>Dentistry</topic><topic>Female</topic><topic>Fibrinogen</topic><topic>Fibrinogen - analysis</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Otorhinolaryngology</topic><topic>Patient compliance</topic><topic>Pediatrics</topic><topic>Physical growth</topic><topic>Plasma</topic><topic>Pneumology/Respiratory System</topic><topic>Polysomnography</topic><topic>Prospective Studies</topic><topic>Restless Legs Syndrome - blood</topic><topic>Restless Legs Syndrome - epidemiology</topic><topic>Risk factors</topic><topic>Sleep</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - blood</topic><topic>Sleep Apnea, Obstructive - epidemiology</topic><topic>Sleep Apnea, Obstructive - therapy</topic><topic>Sleep Breathing Physiology and Disorders • Original Article</topic><topic>Sleep disorders</topic><topic>Titration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murase, Kimihiko</creatorcontrib><creatorcontrib>Azuma, Masanori</creatorcontrib><creatorcontrib>Tachikawa, Ryo</creatorcontrib><creatorcontrib>Minami, Takuma</creatorcontrib><creatorcontrib>Matsumoto, Takeshi</creatorcontrib><creatorcontrib>Hamada, Satoshi</creatorcontrib><creatorcontrib>Nakatsuka, Yoshinari</creatorcontrib><creatorcontrib>Takahashi, Naomi</creatorcontrib><creatorcontrib>Takeyama, Hirofumi</creatorcontrib><creatorcontrib>Tanizawa, Kiminobu</creatorcontrib><creatorcontrib>Oga, Toru</creatorcontrib><creatorcontrib>Handa, Tomohiro</creatorcontrib><creatorcontrib>Hirai, Toyohiro</creatorcontrib><creatorcontrib>Chin, Kazuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>Social Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Sleep & breathing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murase, Kimihiko</au><au>Azuma, Masanori</au><au>Tachikawa, Ryo</au><au>Minami, Takuma</au><au>Matsumoto, Takeshi</au><au>Hamada, Satoshi</au><au>Nakatsuka, Yoshinari</au><au>Takahashi, Naomi</au><au>Takeyama, Hirofumi</au><au>Tanizawa, Kiminobu</au><au>Oga, Toru</au><au>Handa, Tomohiro</au><au>Hirai, Toyohiro</au><au>Chin, Kazuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective associations of sleep apnea, periodic limb movements, and plasma fibrinogen level</atitle><jtitle>Sleep & breathing</jtitle><stitle>Sleep Breath</stitle><addtitle>Sleep Breath</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>25</volume><issue>2</issue><spage>617</spage><epage>625</epage><pages>617-625</pages><issn>1520-9512</issn><eissn>1522-1709</eissn><abstract>Purpose
Our previous cross-sectional study showed that periodic limb movements during sleep (PLMS) were frequently found in patients with obstructive sleep apnea (OSA) and that both OSA and PLMS were associated with higher plasma fibrinogen levels. We explored the longitudinal relationships among these factors.
Methods
Plasma fibrinogen levels were measured in 333 consecutive patients who underwent polysomnography to diagnose OSA. Patients who initiated continuous positive airway pressure (CPAP) underwent follow-up polysomnography after 3 months of CPAP use. They were categorized into groups with good or poor adherence (% days with ≥ 4 h/night of CPAP use ≥ 70% or < 70%, respectively). Changes in sleep parameters and plasma fibrinogen levels during the treatment period were compared between these groups.
Results
The cross-sectional analysis of all reviewed 333 patients indicated that fibrinogen levels were associated with the severities of OSA and PLMS. The 60 patients (27 good and 33 poor adherence) who underwent follow-up polysomnography were included in the longitudinal analysis. The median (interquartile range) periodic limb movement index did not change significantly from CPAP titration to the 3-month follow-up (good adherence: 10.5 (0–23.8) to 10.8 (0–70.2) events/h,
p
= 0.21; poor adherence: 1.2 (0–14.3) to 0.8 (0–15.7) events/h,
p
= 0.67). However, the plasma fibrinogen level significantly decreased only in the good adherence group (good adherence: baseline 275 ± 46 to follow-up 255 ± 47 mg/dl,
p
< 0.01; poor adherence: 277 ± 52 to 284 ± 70 mg/dl,
p
= 0.48).
Conclusions
These results did not support a longitudinal association between PLMS and OSA. However, good adherence to CPAP could reduce plasma fibrinogen levels, thus ameliorating elevations in plasma fibrinogen as a risk factor for future cardiovascular events.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32691209</pmid><doi>10.1007/s11325-020-02147-5</doi><tpages>9</tpages></addata></record> |
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| ispartof | Sleep & breathing, 2021-06, Vol.25 (2), p.617-625 |
| issn | 1520-9512 1522-1709 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Apnea Cardiovascular diseases Continuous positive airway pressure Continuous Positive Airway Pressure - statistics & numerical data Cross-Sectional Studies Dentistry Female Fibrinogen Fibrinogen - analysis Humans Internal Medicine Male Medicine Medicine & Public Health Middle Aged Neurology Otorhinolaryngology Patient compliance Pediatrics Physical growth Plasma Pneumology/Respiratory System Polysomnography Prospective Studies Restless Legs Syndrome - blood Restless Legs Syndrome - epidemiology Risk factors Sleep Sleep apnea Sleep Apnea, Obstructive - blood Sleep Apnea, Obstructive - epidemiology Sleep Apnea, Obstructive - therapy Sleep Breathing Physiology and Disorders • Original Article Sleep disorders Titration |
| title | Prospective associations of sleep apnea, periodic limb movements, and plasma fibrinogen level |
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