Rest‐Activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder
Objective The purpose of this study was to investigate the differences in actigraphy‐measured rest‐activity patterns (eg, sleep–wake cycle, circadian rest‐activity rhythm, and physical activity) across different stages of α‐synucleinopathy. Methods We compared alterations in 7‐day actigraphy‐measure...
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| Veröffentlicht in: | Annals of neurology 2020-10, Vol.88 (4), p.817-829 |
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| container_title | Annals of neurology |
| container_volume | 88 |
| creator | Feng, Hongliang Chen, Lauren Liu, Yaping Chen, Xinru Wang, Jing Yu, Mandy Wai Man Huang, Bei Li, Shirley Xin Chau, Steven Wai Ho Chan, Joey Wing Yan Chen, Jie Mok, Vincent Chung Tong Wing, Yun Kwok Zhang, Jihui |
| description | Objective
The purpose of this study was to investigate the differences in actigraphy‐measured rest‐activity patterns (eg, sleep–wake cycle, circadian rest‐activity rhythm, and physical activity) across different stages of α‐synucleinopathy.
Methods
We compared alterations in 7‐day actigraphy‐measured rest‐activity patterns among patients with clinically diagnosed α‐synucleinopathies (n = 44), and their age‐, sex‐, and body mass index (BMI)‐matched patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD, n = 88), and non‐rapid eye movement (REM) sleep behavior disorder (RBD) controls (n = 44) in a case–control study (study 1) and between convertors (n = 22) and their age‐, sex‐, BMI‐, iRBD‐duration, and follow‐up duration‐matched non‐convertors (n = 66) in a prospective nested case–control study (study 2).
Results
In study 1, there were significant increases (all p values were adjusted by false discovery rate |
| doi_str_mv | 10.1002/ana.25853 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2425898299</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2425898299</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2683-9ec7d008411fb22421560407fc840f9810f39368daa1b5f72b30d002ca55b2eb3</originalsourceid><addsrcrecordid>eNp10D9OwzAchmELgWgpDFwARWKBIcV_E3sMpUClFlCBOXISR3WVJsFOirpxBM7ISTCkMCAx_ZZHr-wPgGMEhwhCfCFLOcSMM7ID-ogR5HNMxS7oQxJQnyFCe-DA2iWEUAQI7oMewYFAlOI-mM2VbT7e3qO00WvdbLwH2TTKlF5UuCMbXZXW06U3yXRVy2ahU28-nnmPhVK1d6kWcq0r411pW5lMmUOwl8vCqqPtHYDn6_HT6Naf3t9MRtHUT3HAiS9UGmYQcopQnmBMMWIBpDDMU05hLjiCOREk4JmUKGF5iBMCncepZCzBKiEDcNZ1a1O9tO4H8UrbVBWFLFXV2tglGRccC-Ho6R-6rFpTutc5RUnoCA6dOu9Uaiprjcrj2uiVNJsYwfhr49htHH9v7OzJttgmK5X9yp9RHbjowKsu1Ob_UhzdRV3yE6nIhB8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2443799327</pqid></control><display><type>article</type><title>Rest‐Activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Feng, Hongliang ; Chen, Lauren ; Liu, Yaping ; Chen, Xinru ; Wang, Jing ; Yu, Mandy Wai Man ; Huang, Bei ; Li, Shirley Xin ; Chau, Steven Wai Ho ; Chan, Joey Wing Yan ; Chen, Jie ; Mok, Vincent Chung Tong ; Wing, Yun Kwok ; Zhang, Jihui</creator><creatorcontrib>Feng, Hongliang ; Chen, Lauren ; Liu, Yaping ; Chen, Xinru ; Wang, Jing ; Yu, Mandy Wai Man ; Huang, Bei ; Li, Shirley Xin ; Chau, Steven Wai Ho ; Chan, Joey Wing Yan ; Chen, Jie ; Mok, Vincent Chung Tong ; Wing, Yun Kwok ; Zhang, Jihui</creatorcontrib><description>Objective
The purpose of this study was to investigate the differences in actigraphy‐measured rest‐activity patterns (eg, sleep–wake cycle, circadian rest‐activity rhythm, and physical activity) across different stages of α‐synucleinopathy.
Methods
We compared alterations in 7‐day actigraphy‐measured rest‐activity patterns among patients with clinically diagnosed α‐synucleinopathies (n = 44), and their age‐, sex‐, and body mass index (BMI)‐matched patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD, n = 88), and non‐rapid eye movement (REM) sleep behavior disorder (RBD) controls (n = 44) in a case–control study (study 1) and between convertors (n = 22) and their age‐, sex‐, BMI‐, iRBD‐duration, and follow‐up duration‐matched non‐convertors (n = 66) in a prospective nested case–control study (study 2).
Results
In study 1, there were significant increases (all p values were adjusted by false discovery rate < 0.01) in probable napping behaviors (percentage, duration, and episodes), activity fragmentation (estimated by kAR), and physical inactivity during active periods across controls, and iRBD, to clinically diagnosed α‐synucleinopathies. In study 2, higher levels (all p values were adjusted by false discovery rate < 0.05) of baseline objective probable napping, activity fragmentation, and physical inactivity during active periods were associated with the conversion of patients with iRBD into clinically diagnosed α‐synucleinopathies at 2 years of follow‐up with medium to large effect sizes (Cohen's d: 0.56 to 0.80). These findings were further supported by functional linear modeling analyses.
Interpretation
Rest‐activity pattern alterations, mainly objective probable napping behaviors, activity fragmentation, and physical inactivity during active period, emerge as early as at the stage of iRBD, which serves as early and robust prodromal markers of the conversion of iRBD into clinically diagnosed α‐synucleinopathies. ANN NEUROL 2020;88:817–829</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.25853</identifier><identifier>PMID: 32691442</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Actigraphy ; Active control ; Activity patterns ; Aged ; Aged, 80 and over ; Behavior disorders ; Body mass ; Body mass index ; Body size ; Case-Control Studies ; Circadian rhythms ; Conversion ; Disease Progression ; Eye movements ; Female ; Fragmentation ; Humans ; Male ; Middle Aged ; Physical activity ; Prodromal Symptoms ; REM sleep ; REM Sleep Behavior Disorder - diagnosis ; Rest ; Sex ; Sleep ; Sleep and wakefulness ; Sleep disorders ; Synucleinopathies - diagnosis</subject><ispartof>Annals of neurology, 2020-10, Vol.88 (4), p.817-829</ispartof><rights>2020 American Neurological Association</rights><rights>2020 American Neurological Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2683-9ec7d008411fb22421560407fc840f9810f39368daa1b5f72b30d002ca55b2eb3</citedby><cites>FETCH-LOGICAL-c2683-9ec7d008411fb22421560407fc840f9810f39368daa1b5f72b30d002ca55b2eb3</cites><orcidid>0000-0002-4976-3039 ; 0000-0003-3291-7780 ; 0000-0002-9906-8712</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.25853$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.25853$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32691442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feng, Hongliang</creatorcontrib><creatorcontrib>Chen, Lauren</creatorcontrib><creatorcontrib>Liu, Yaping</creatorcontrib><creatorcontrib>Chen, Xinru</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Yu, Mandy Wai Man</creatorcontrib><creatorcontrib>Huang, Bei</creatorcontrib><creatorcontrib>Li, Shirley Xin</creatorcontrib><creatorcontrib>Chau, Steven Wai Ho</creatorcontrib><creatorcontrib>Chan, Joey Wing Yan</creatorcontrib><creatorcontrib>Chen, Jie</creatorcontrib><creatorcontrib>Mok, Vincent Chung Tong</creatorcontrib><creatorcontrib>Wing, Yun Kwok</creatorcontrib><creatorcontrib>Zhang, Jihui</creatorcontrib><title>Rest‐Activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Objective
The purpose of this study was to investigate the differences in actigraphy‐measured rest‐activity patterns (eg, sleep–wake cycle, circadian rest‐activity rhythm, and physical activity) across different stages of α‐synucleinopathy.
Methods
We compared alterations in 7‐day actigraphy‐measured rest‐activity patterns among patients with clinically diagnosed α‐synucleinopathies (n = 44), and their age‐, sex‐, and body mass index (BMI)‐matched patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD, n = 88), and non‐rapid eye movement (REM) sleep behavior disorder (RBD) controls (n = 44) in a case–control study (study 1) and between convertors (n = 22) and their age‐, sex‐, BMI‐, iRBD‐duration, and follow‐up duration‐matched non‐convertors (n = 66) in a prospective nested case–control study (study 2).
Results
In study 1, there were significant increases (all p values were adjusted by false discovery rate < 0.01) in probable napping behaviors (percentage, duration, and episodes), activity fragmentation (estimated by kAR), and physical inactivity during active periods across controls, and iRBD, to clinically diagnosed α‐synucleinopathies. In study 2, higher levels (all p values were adjusted by false discovery rate < 0.05) of baseline objective probable napping, activity fragmentation, and physical inactivity during active periods were associated with the conversion of patients with iRBD into clinically diagnosed α‐synucleinopathies at 2 years of follow‐up with medium to large effect sizes (Cohen's d: 0.56 to 0.80). These findings were further supported by functional linear modeling analyses.
Interpretation
Rest‐activity pattern alterations, mainly objective probable napping behaviors, activity fragmentation, and physical inactivity during active period, emerge as early as at the stage of iRBD, which serves as early and robust prodromal markers of the conversion of iRBD into clinically diagnosed α‐synucleinopathies. ANN NEUROL 2020;88:817–829</description><subject>Actigraphy</subject><subject>Active control</subject><subject>Activity patterns</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Behavior disorders</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Case-Control Studies</subject><subject>Circadian rhythms</subject><subject>Conversion</subject><subject>Disease Progression</subject><subject>Eye movements</subject><subject>Female</subject><subject>Fragmentation</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Physical activity</subject><subject>Prodromal Symptoms</subject><subject>REM sleep</subject><subject>REM Sleep Behavior Disorder - diagnosis</subject><subject>Rest</subject><subject>Sex</subject><subject>Sleep</subject><subject>Sleep and wakefulness</subject><subject>Sleep disorders</subject><subject>Synucleinopathies - diagnosis</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10D9OwzAchmELgWgpDFwARWKBIcV_E3sMpUClFlCBOXISR3WVJsFOirpxBM7ISTCkMCAx_ZZHr-wPgGMEhwhCfCFLOcSMM7ID-ogR5HNMxS7oQxJQnyFCe-DA2iWEUAQI7oMewYFAlOI-mM2VbT7e3qO00WvdbLwH2TTKlF5UuCMbXZXW06U3yXRVy2ahU28-nnmPhVK1d6kWcq0r411pW5lMmUOwl8vCqqPtHYDn6_HT6Naf3t9MRtHUT3HAiS9UGmYQcopQnmBMMWIBpDDMU05hLjiCOREk4JmUKGF5iBMCncepZCzBKiEDcNZ1a1O9tO4H8UrbVBWFLFXV2tglGRccC-Ho6R-6rFpTutc5RUnoCA6dOu9Uaiprjcrj2uiVNJsYwfhr49htHH9v7OzJttgmK5X9yp9RHbjowKsu1Ob_UhzdRV3yE6nIhB8</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Feng, Hongliang</creator><creator>Chen, Lauren</creator><creator>Liu, Yaping</creator><creator>Chen, Xinru</creator><creator>Wang, Jing</creator><creator>Yu, Mandy Wai Man</creator><creator>Huang, Bei</creator><creator>Li, Shirley Xin</creator><creator>Chau, Steven Wai Ho</creator><creator>Chan, Joey Wing Yan</creator><creator>Chen, Jie</creator><creator>Mok, Vincent Chung Tong</creator><creator>Wing, Yun Kwok</creator><creator>Zhang, Jihui</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4976-3039</orcidid><orcidid>https://orcid.org/0000-0003-3291-7780</orcidid><orcidid>https://orcid.org/0000-0002-9906-8712</orcidid></search><sort><creationdate>202010</creationdate><title>Rest‐Activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder</title><author>Feng, Hongliang ; Chen, Lauren ; Liu, Yaping ; Chen, Xinru ; Wang, Jing ; Yu, Mandy Wai Man ; Huang, Bei ; Li, Shirley Xin ; Chau, Steven Wai Ho ; Chan, Joey Wing Yan ; Chen, Jie ; Mok, Vincent Chung Tong ; Wing, Yun Kwok ; Zhang, Jihui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2683-9ec7d008411fb22421560407fc840f9810f39368daa1b5f72b30d002ca55b2eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Actigraphy</topic><topic>Active control</topic><topic>Activity patterns</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Behavior disorders</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Case-Control Studies</topic><topic>Circadian rhythms</topic><topic>Conversion</topic><topic>Disease Progression</topic><topic>Eye movements</topic><topic>Female</topic><topic>Fragmentation</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Physical activity</topic><topic>Prodromal Symptoms</topic><topic>REM sleep</topic><topic>REM Sleep Behavior Disorder - diagnosis</topic><topic>Rest</topic><topic>Sex</topic><topic>Sleep</topic><topic>Sleep and wakefulness</topic><topic>Sleep disorders</topic><topic>Synucleinopathies - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feng, Hongliang</creatorcontrib><creatorcontrib>Chen, Lauren</creatorcontrib><creatorcontrib>Liu, Yaping</creatorcontrib><creatorcontrib>Chen, Xinru</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Yu, Mandy Wai Man</creatorcontrib><creatorcontrib>Huang, Bei</creatorcontrib><creatorcontrib>Li, Shirley Xin</creatorcontrib><creatorcontrib>Chau, Steven Wai Ho</creatorcontrib><creatorcontrib>Chan, Joey Wing Yan</creatorcontrib><creatorcontrib>Chen, Jie</creatorcontrib><creatorcontrib>Mok, Vincent Chung Tong</creatorcontrib><creatorcontrib>Wing, Yun Kwok</creatorcontrib><creatorcontrib>Zhang, Jihui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feng, Hongliang</au><au>Chen, Lauren</au><au>Liu, Yaping</au><au>Chen, Xinru</au><au>Wang, Jing</au><au>Yu, Mandy Wai Man</au><au>Huang, Bei</au><au>Li, Shirley Xin</au><au>Chau, Steven Wai Ho</au><au>Chan, Joey Wing Yan</au><au>Chen, Jie</au><au>Mok, Vincent Chung Tong</au><au>Wing, Yun Kwok</au><au>Zhang, Jihui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rest‐Activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2020-10</date><risdate>2020</risdate><volume>88</volume><issue>4</issue><spage>817</spage><epage>829</epage><pages>817-829</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><abstract>Objective
The purpose of this study was to investigate the differences in actigraphy‐measured rest‐activity patterns (eg, sleep–wake cycle, circadian rest‐activity rhythm, and physical activity) across different stages of α‐synucleinopathy.
Methods
We compared alterations in 7‐day actigraphy‐measured rest‐activity patterns among patients with clinically diagnosed α‐synucleinopathies (n = 44), and their age‐, sex‐, and body mass index (BMI)‐matched patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD, n = 88), and non‐rapid eye movement (REM) sleep behavior disorder (RBD) controls (n = 44) in a case–control study (study 1) and between convertors (n = 22) and their age‐, sex‐, BMI‐, iRBD‐duration, and follow‐up duration‐matched non‐convertors (n = 66) in a prospective nested case–control study (study 2).
Results
In study 1, there were significant increases (all p values were adjusted by false discovery rate < 0.01) in probable napping behaviors (percentage, duration, and episodes), activity fragmentation (estimated by kAR), and physical inactivity during active periods across controls, and iRBD, to clinically diagnosed α‐synucleinopathies. In study 2, higher levels (all p values were adjusted by false discovery rate < 0.05) of baseline objective probable napping, activity fragmentation, and physical inactivity during active periods were associated with the conversion of patients with iRBD into clinically diagnosed α‐synucleinopathies at 2 years of follow‐up with medium to large effect sizes (Cohen's d: 0.56 to 0.80). These findings were further supported by functional linear modeling analyses.
Interpretation
Rest‐activity pattern alterations, mainly objective probable napping behaviors, activity fragmentation, and physical inactivity during active period, emerge as early as at the stage of iRBD, which serves as early and robust prodromal markers of the conversion of iRBD into clinically diagnosed α‐synucleinopathies. ANN NEUROL 2020;88:817–829</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32691442</pmid><doi>10.1002/ana.25853</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-4976-3039</orcidid><orcidid>https://orcid.org/0000-0003-3291-7780</orcidid><orcidid>https://orcid.org/0000-0002-9906-8712</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Actigraphy Active control Activity patterns Aged Aged, 80 and over Behavior disorders Body mass Body mass index Body size Case-Control Studies Circadian rhythms Conversion Disease Progression Eye movements Female Fragmentation Humans Male Middle Aged Physical activity Prodromal Symptoms REM sleep REM Sleep Behavior Disorder - diagnosis Rest Sex Sleep Sleep and wakefulness Sleep disorders Synucleinopathies - diagnosis |
| title | Rest‐Activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder |
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