Determination of Third-Generation Synthetic Cannabinoids in Oral Fluids

Determination of Third-Generation Synthetic Cannabinoids in Oral Fluids

A procedure has been developed for the determination of third-generation synthetic cannabinoids in oral fluid samples by using a semi-automated microextraction by packed sorbent (MEPS) procedure and gas chromatography-mass spectrometry (GC-MS) determination. Five synthetic cannabinoids were employed...

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Veröffentlicht in:Journal of analytical toxicology 2021-04, Vol.45 (4), p.331-336
Hauptverfasser: Sorribes-Soriano, Aitor, Verdeguer, Josep, Pastor, Agustín, Armenta, Sergio, Esteve-Turrillas, Francesc A
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Sprache:eng
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Cannabinoids - analysis
Gas Chromatography-Mass Spectrometry
Illicit Drugs
Saliva - chemistry
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container_end_page 336
container_issue 4
container_start_page 331
container_title Journal of analytical toxicology
container_volume 45
creator Sorribes-Soriano, Aitor
Verdeguer, Josep
Pastor, Agustín
Armenta, Sergio
Esteve-Turrillas, Francesc A
description A procedure has been developed for the determination of third-generation synthetic cannabinoids in oral fluid samples by using a semi-automated microextraction by packed sorbent (MEPS) procedure and gas chromatography-mass spectrometry (GC-MS) determination. Five synthetic cannabinoids were employed as model compounds 5F-ADB, MMB-CHMICA, THJ-2201, CUMYL-4CN-BINACA and MDMB-CHMCZCA. The most adequate operative conditions for MEPS were evaluated giving quantitative recoveries, from 89 to 124%, in synthetic and field saliva samples spiked with 125 and 250 μg/L of the studied cannabinoids, with the exception of MDMB-CHMCZCA in field saliva samples that provided slightly lower recoveries from 62 to 66%. A high sensitivity was obtained for the proposed MEPS-GC-MS procedure with limits of detection from 10 to 20 μg/L. The obtained results demonstrate the high potential of MEPS-GC-MS combination for semi-automated, selective and sensitive determination of synthetic cannabinoids in oral fluid samples.
doi_str_mv 10.1093/jat/bkaa091
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection
subjects Cannabinoids - analysis
Gas Chromatography-Mass Spectrometry
Illicit Drugs
Saliva - chemistry
title Determination of Third-Generation Synthetic Cannabinoids in Oral Fluids
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