Inhibition of macrophage migration inhibitory factor prevents thyroid dysfunction in pregnant rats with acute pancreatitis
•Macrophages and T lymphocytes were involved in thyroid injury.•MIF plays a significant role in thyroid injury in pregnant rats.•ISO-1 could improve inflammation and oxidative stress effectively in the thyroid of pregnant rats. Acute pancreatitis during pregnancy (APIP) rarely occurs but may lead to...
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| Veröffentlicht in: | International immunopharmacology 2020-10, Vol.87, p.106771-106771, Article 106771 |
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| creator | Chen, Ying Wang, Chen-yang Zhao, Liang Hong, Yu-pu Zhang, Xiao-yi Mei, Fang-chao Zhou, Yu Guo, Wen-yi Shi, Qiao Zhao, Kai-liang Chen, Chen Yu, Jia Wang, Wei-xing |
| description | •Macrophages and T lymphocytes were involved in thyroid injury.•MIF plays a significant role in thyroid injury in pregnant rats.•ISO-1 could improve inflammation and oxidative stress effectively in the thyroid of pregnant rats.
Acute pancreatitis during pregnancy (APIP) rarely occurs but may lead to preterm delivery and be associated with high fetal mortality. Macrophage migration inhibitory factor (MIF) participates in various inflammatory diseases as a pro-inflammatory cytokine. In this study, we aimed to explore the effects of (S, R)-3-(4-hydroxyphenyl)-4, 5dihydro-5-isoxazole acetic methyl ester (ISO-1), an inhibitor of MIF, on maternal thyroid injury associated with APIP and its potential mechanisms in a pregnant rat model. APIP model was induced by retrograde injection of sodium taurocholate. ISO-1 was injected intraperitoneally 30 min before model establishment. The severity of pancreatitis was assessed by levels of tumor necrosis factor (TNF)‑α, interleukin (IL)‑1β, IL-6 of maternal serum as well as histopathological score. Thyroid injury was determined by free triiodothyronine (FT3), free tetraiodothyronine (FT4) and thyroid histopathological score. Levels of MIF in maternal serum and the expression of MIF, CD68, CD3 and intercellular cell adhesion molecule-1 (ICAM-1) as well as oxidative stress status in maternal thyroid tissues were detected. Ultrastructure of maternal thyroid tissues was observed by transmission electron microscope. Thyroid injuries occurred in APIP and the lesions were attenuated with the pretreatment of ISO-1. Moreover, ISO-1 reduced the expression of MIF, attenuated the activations of CD68, CD3, ICAM-1 while improved oxidative stress status in maternal thyroid. Our research suggested a protective role of ISO-1 on thyroid injury and endocrine disorder during APIP, which may be associated with the inhibition of biological functions of MIF. |
| doi_str_mv | 10.1016/j.intimp.2020.106771 |
| format | Article |
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Acute pancreatitis during pregnancy (APIP) rarely occurs but may lead to preterm delivery and be associated with high fetal mortality. Macrophage migration inhibitory factor (MIF) participates in various inflammatory diseases as a pro-inflammatory cytokine. In this study, we aimed to explore the effects of (S, R)-3-(4-hydroxyphenyl)-4, 5dihydro-5-isoxazole acetic methyl ester (ISO-1), an inhibitor of MIF, on maternal thyroid injury associated with APIP and its potential mechanisms in a pregnant rat model. APIP model was induced by retrograde injection of sodium taurocholate. ISO-1 was injected intraperitoneally 30 min before model establishment. The severity of pancreatitis was assessed by levels of tumor necrosis factor (TNF)‑α, interleukin (IL)‑1β, IL-6 of maternal serum as well as histopathological score. Thyroid injury was determined by free triiodothyronine (FT3), free tetraiodothyronine (FT4) and thyroid histopathological score. Levels of MIF in maternal serum and the expression of MIF, CD68, CD3 and intercellular cell adhesion molecule-1 (ICAM-1) as well as oxidative stress status in maternal thyroid tissues were detected. Ultrastructure of maternal thyroid tissues was observed by transmission electron microscope. Thyroid injuries occurred in APIP and the lesions were attenuated with the pretreatment of ISO-1. Moreover, ISO-1 reduced the expression of MIF, attenuated the activations of CD68, CD3, ICAM-1 while improved oxidative stress status in maternal thyroid. Our research suggested a protective role of ISO-1 on thyroid injury and endocrine disorder during APIP, which may be associated with the inhibition of biological functions of MIF.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2020.106771</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acute pancreatitis ; CD3 antigen ; Cell adhesion ; Cell adhesion & migration ; Cell adhesion molecules ; Cytokines ; Fetuses ; Inflammatory diseases ; Injuries ; Intercellular adhesion molecule 1 ; Interleukin 6 ; Leukocyte migration ; Macrophage migration inhibitory factor ; Oxidative stress ; Pancreatitis ; Pregnancy ; Thyroid ; Thyroid diseases ; Thyroid dysfunction ; Thyroid gland ; Thyroid hormones ; Triiodothyronine ; Tumor necrosis factor ; Tumor necrosis factor-TNF ; Ultrastructure</subject><ispartof>International immunopharmacology, 2020-10, Vol.87, p.106771-106771, Article 106771</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright Elsevier BV Oct 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-1d1b0681049c38064f0c9970d213c8c3a37dc376f88170f5c9201d0e4b117d2f3</citedby><cites>FETCH-LOGICAL-c367t-1d1b0681049c38064f0c9970d213c8c3a37dc376f88170f5c9201d0e4b117d2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2020.106771$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids></links><search><creatorcontrib>Chen, Ying</creatorcontrib><creatorcontrib>Wang, Chen-yang</creatorcontrib><creatorcontrib>Zhao, Liang</creatorcontrib><creatorcontrib>Hong, Yu-pu</creatorcontrib><creatorcontrib>Zhang, Xiao-yi</creatorcontrib><creatorcontrib>Mei, Fang-chao</creatorcontrib><creatorcontrib>Zhou, Yu</creatorcontrib><creatorcontrib>Guo, Wen-yi</creatorcontrib><creatorcontrib>Shi, Qiao</creatorcontrib><creatorcontrib>Zhao, Kai-liang</creatorcontrib><creatorcontrib>Chen, Chen</creatorcontrib><creatorcontrib>Yu, Jia</creatorcontrib><creatorcontrib>Wang, Wei-xing</creatorcontrib><title>Inhibition of macrophage migration inhibitory factor prevents thyroid dysfunction in pregnant rats with acute pancreatitis</title><title>International immunopharmacology</title><description>•Macrophages and T lymphocytes were involved in thyroid injury.•MIF plays a significant role in thyroid injury in pregnant rats.•ISO-1 could improve inflammation and oxidative stress effectively in the thyroid of pregnant rats.
Acute pancreatitis during pregnancy (APIP) rarely occurs but may lead to preterm delivery and be associated with high fetal mortality. Macrophage migration inhibitory factor (MIF) participates in various inflammatory diseases as a pro-inflammatory cytokine. In this study, we aimed to explore the effects of (S, R)-3-(4-hydroxyphenyl)-4, 5dihydro-5-isoxazole acetic methyl ester (ISO-1), an inhibitor of MIF, on maternal thyroid injury associated with APIP and its potential mechanisms in a pregnant rat model. APIP model was induced by retrograde injection of sodium taurocholate. ISO-1 was injected intraperitoneally 30 min before model establishment. The severity of pancreatitis was assessed by levels of tumor necrosis factor (TNF)‑α, interleukin (IL)‑1β, IL-6 of maternal serum as well as histopathological score. Thyroid injury was determined by free triiodothyronine (FT3), free tetraiodothyronine (FT4) and thyroid histopathological score. Levels of MIF in maternal serum and the expression of MIF, CD68, CD3 and intercellular cell adhesion molecule-1 (ICAM-1) as well as oxidative stress status in maternal thyroid tissues were detected. Ultrastructure of maternal thyroid tissues was observed by transmission electron microscope. Thyroid injuries occurred in APIP and the lesions were attenuated with the pretreatment of ISO-1. Moreover, ISO-1 reduced the expression of MIF, attenuated the activations of CD68, CD3, ICAM-1 while improved oxidative stress status in maternal thyroid. Our research suggested a protective role of ISO-1 on thyroid injury and endocrine disorder during APIP, which may be associated with the inhibition of biological functions of MIF.</description><subject>Acute pancreatitis</subject><subject>CD3 antigen</subject><subject>Cell adhesion</subject><subject>Cell adhesion & migration</subject><subject>Cell adhesion molecules</subject><subject>Cytokines</subject><subject>Fetuses</subject><subject>Inflammatory diseases</subject><subject>Injuries</subject><subject>Intercellular adhesion molecule 1</subject><subject>Interleukin 6</subject><subject>Leukocyte migration</subject><subject>Macrophage migration inhibitory factor</subject><subject>Oxidative stress</subject><subject>Pancreatitis</subject><subject>Pregnancy</subject><subject>Thyroid</subject><subject>Thyroid diseases</subject><subject>Thyroid dysfunction</subject><subject>Thyroid gland</subject><subject>Thyroid hormones</subject><subject>Triiodothyronine</subject><subject>Tumor necrosis factor</subject><subject>Tumor necrosis factor-TNF</subject><subject>Ultrastructure</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kTtPwzAUhSMEEqXwDxgssbCk2IkTOwsSqnhUQmKB2XL9aB01drCdovDrcUknBqZ7dfzdI997suwawQWCqL5rF8ZG0_WLAhYHqSYEnWQzRAnNEYHVaeqrmuQVqZvz7CKEFsKkYzTLvld2a9YmGmeB06Djwrt-yzcKdGbj-a9uJsT5EWguUgW9V3tlYwBxO3pnJJBj0IMVR_zwvrHcRpAcAvgycQu4GKICPbfCq2QbTbjMzjTfBXV1rPPs4-nxffmSv749r5YPr7koaxJzJNEa1hRB3IiSwhprKJqGQFmgUlBR8pJIUZJaU5p20pVoCogkVHiNEJGFLufZ7eTbe_c5qBBZZ4JQux23yg2BFbioqqbEkCb05g_ausHb9LtEVRjjgtAqUXii0q1C8Eqz3puO-5EhyA6BsJZNgbBDIGwKJI3dT2MqLbs3yrMgjLJCSeOViEw687_BD8W1l8s</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Chen, Ying</creator><creator>Wang, Chen-yang</creator><creator>Zhao, Liang</creator><creator>Hong, Yu-pu</creator><creator>Zhang, Xiao-yi</creator><creator>Mei, Fang-chao</creator><creator>Zhou, Yu</creator><creator>Guo, Wen-yi</creator><creator>Shi, Qiao</creator><creator>Zhao, Kai-liang</creator><creator>Chen, Chen</creator><creator>Yu, Jia</creator><creator>Wang, Wei-xing</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>202010</creationdate><title>Inhibition of macrophage migration inhibitory factor prevents thyroid dysfunction in pregnant rats with acute pancreatitis</title><author>Chen, Ying ; Wang, Chen-yang ; Zhao, Liang ; Hong, Yu-pu ; Zhang, Xiao-yi ; Mei, Fang-chao ; Zhou, Yu ; Guo, Wen-yi ; Shi, Qiao ; Zhao, Kai-liang ; Chen, Chen ; Yu, Jia ; Wang, Wei-xing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-1d1b0681049c38064f0c9970d213c8c3a37dc376f88170f5c9201d0e4b117d2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute pancreatitis</topic><topic>CD3 antigen</topic><topic>Cell adhesion</topic><topic>Cell adhesion & migration</topic><topic>Cell adhesion molecules</topic><topic>Cytokines</topic><topic>Fetuses</topic><topic>Inflammatory diseases</topic><topic>Injuries</topic><topic>Intercellular adhesion molecule 1</topic><topic>Interleukin 6</topic><topic>Leukocyte migration</topic><topic>Macrophage migration inhibitory factor</topic><topic>Oxidative stress</topic><topic>Pancreatitis</topic><topic>Pregnancy</topic><topic>Thyroid</topic><topic>Thyroid diseases</topic><topic>Thyroid dysfunction</topic><topic>Thyroid gland</topic><topic>Thyroid hormones</topic><topic>Triiodothyronine</topic><topic>Tumor necrosis factor</topic><topic>Tumor necrosis factor-TNF</topic><topic>Ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ying</creatorcontrib><creatorcontrib>Wang, Chen-yang</creatorcontrib><creatorcontrib>Zhao, Liang</creatorcontrib><creatorcontrib>Hong, Yu-pu</creatorcontrib><creatorcontrib>Zhang, Xiao-yi</creatorcontrib><creatorcontrib>Mei, Fang-chao</creatorcontrib><creatorcontrib>Zhou, Yu</creatorcontrib><creatorcontrib>Guo, Wen-yi</creatorcontrib><creatorcontrib>Shi, Qiao</creatorcontrib><creatorcontrib>Zhao, Kai-liang</creatorcontrib><creatorcontrib>Chen, Chen</creatorcontrib><creatorcontrib>Yu, Jia</creatorcontrib><creatorcontrib>Wang, Wei-xing</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ying</au><au>Wang, Chen-yang</au><au>Zhao, Liang</au><au>Hong, Yu-pu</au><au>Zhang, Xiao-yi</au><au>Mei, Fang-chao</au><au>Zhou, Yu</au><au>Guo, Wen-yi</au><au>Shi, Qiao</au><au>Zhao, Kai-liang</au><au>Chen, Chen</au><au>Yu, Jia</au><au>Wang, Wei-xing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of macrophage migration inhibitory factor prevents thyroid dysfunction in pregnant rats with acute pancreatitis</atitle><jtitle>International immunopharmacology</jtitle><date>2020-10</date><risdate>2020</risdate><volume>87</volume><spage>106771</spage><epage>106771</epage><pages>106771-106771</pages><artnum>106771</artnum><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>•Macrophages and T lymphocytes were involved in thyroid injury.•MIF plays a significant role in thyroid injury in pregnant rats.•ISO-1 could improve inflammation and oxidative stress effectively in the thyroid of pregnant rats.
Acute pancreatitis during pregnancy (APIP) rarely occurs but may lead to preterm delivery and be associated with high fetal mortality. Macrophage migration inhibitory factor (MIF) participates in various inflammatory diseases as a pro-inflammatory cytokine. In this study, we aimed to explore the effects of (S, R)-3-(4-hydroxyphenyl)-4, 5dihydro-5-isoxazole acetic methyl ester (ISO-1), an inhibitor of MIF, on maternal thyroid injury associated with APIP and its potential mechanisms in a pregnant rat model. APIP model was induced by retrograde injection of sodium taurocholate. ISO-1 was injected intraperitoneally 30 min before model establishment. The severity of pancreatitis was assessed by levels of tumor necrosis factor (TNF)‑α, interleukin (IL)‑1β, IL-6 of maternal serum as well as histopathological score. Thyroid injury was determined by free triiodothyronine (FT3), free tetraiodothyronine (FT4) and thyroid histopathological score. Levels of MIF in maternal serum and the expression of MIF, CD68, CD3 and intercellular cell adhesion molecule-1 (ICAM-1) as well as oxidative stress status in maternal thyroid tissues were detected. Ultrastructure of maternal thyroid tissues was observed by transmission electron microscope. Thyroid injuries occurred in APIP and the lesions were attenuated with the pretreatment of ISO-1. Moreover, ISO-1 reduced the expression of MIF, attenuated the activations of CD68, CD3, ICAM-1 while improved oxidative stress status in maternal thyroid. Our research suggested a protective role of ISO-1 on thyroid injury and endocrine disorder during APIP, which may be associated with the inhibition of biological functions of MIF.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><doi>10.1016/j.intimp.2020.106771</doi><tpages>1</tpages></addata></record> |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Acute pancreatitis CD3 antigen Cell adhesion Cell adhesion & migration Cell adhesion molecules Cytokines Fetuses Inflammatory diseases Injuries Intercellular adhesion molecule 1 Interleukin 6 Leukocyte migration Macrophage migration inhibitory factor Oxidative stress Pancreatitis Pregnancy Thyroid Thyroid diseases Thyroid dysfunction Thyroid gland Thyroid hormones Triiodothyronine Tumor necrosis factor Tumor necrosis factor-TNF Ultrastructure |
| title | Inhibition of macrophage migration inhibitory factor prevents thyroid dysfunction in pregnant rats with acute pancreatitis |
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