Establishment and characterization of Neu1-knockout zebrafish and its abnormal clinical phenotypes

Mammalian sialidase Neu1 is involved in various physiological functions, including cell adhesion, differentiation, cancer metastasis, and diabetes through lysosomal catabolism and desialylation of glycoproteins at the plasma membrane. Various animal models have been established to further explore th...

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Veröffentlicht in:	Biochemical journal 2020-08, Vol.477 (15), p.2841-2857
Hauptverfasser:	Okada, Keiji, Takase, Ryo, Hamaoka, Yurie, Honda, Akinobu, Ikeda, Asami, Hokazono, Yoichiro, Maeda, Yutaro, Hayasaka, Oki, Kotani, Tomonari, Komatsu, Masaharu, Shiozaki, Kazuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Body Weight - genetics CRISPR-Cas Systems Disease Models, Animal Embryo, Nonmammalian Female Gene Expression Regulation, Developmental Gene Knockout Techniques Glycoproteins - genetics Glycoproteins - metabolism HEK293 Cells Humans Hydrogen-Ion Concentration Male Mucolipidoses - etiology Mucolipidoses - genetics N-Acetylneuraminic Acid - metabolism Neuraminidase - genetics Neuraminidase - metabolism Osteogenesis - genetics Phenotype Zebrafish - embryology Zebrafish - genetics Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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