Mid‐gestational fetal placental blood flow is diminished in the fetus with congenital heart disease

Mid‐gestational fetal placental blood flow is diminished in the fetus with congenital heart disease

Objective Data suggest fetuses with congenital heart disease (CHD) have placental abnormalities. Their abnormal placental vasculature may affect fetal placental blood flow, which has not previously been explored. Method We performed a retrospective cross‐sectional study comparing umbilical venous vo...

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Veröffentlicht in:Prenatal diagnosis 2020-10, Vol.40 (11), p.1432-1438
Hauptverfasser: Ho, Deborah Y., Josowitz, Rebecca, Katcoff, Hannah, Griffis, Heather M., Tian, Zhiyun, Gaynor, J. William, Rychik, Jack
Format: Artikel
Sprache:eng
Schlagworte:
Abnormalities
Arteries
Blood flow
Cardiac output
Cardiovascular disease
Cardiovascular diseases
Congenital diseases
Coronary artery disease
Echocardiography
Fetuses
Gestational age
Heart diseases
Placenta
Subgroups
Tetralogy of Fallot
Transposition
Ventricle
Weight
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Zusammenfassung:Objective Data suggest fetuses with congenital heart disease (CHD) have placental abnormalities. Their abnormal placental vasculature may affect fetal placental blood flow, which has not previously been explored. Method We performed a retrospective cross‐sectional study comparing umbilical venous volume flow (UVVF) of single ventricle, D‐transposition of the great arteries, and tetralogy of Fallot fetuses with fetuses without CHD. UVVF and combined cardiac output (CCO) were calculated from fetal echocardiography and compared using t tests, χ2 and Fisher's exact tests. Results Mean gestational age and fetal weight were greater in CHD fetuses (26.5 weeks, 1119.4 g; n = 81, P 
ISSN:0197-3851
1097-0223
DOI:10.1002/pd.5791