Intravoxel incoherent motion diffusion-weighted imaging for discrimination of benign and malignant retropharyngeal nodes
Purpose Anatomical imaging criteria for the diagnosis of malignant head and neck nodes may not always be reliable. This study aimed to evaluate the diagnostic value of conventional diffusion-weighted imaging (DWI) and intravoxel incoherent motion (IVIM) DWI in discriminating benign and malignant met...
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| Veröffentlicht in: | Neuroradiology 2020-12, Vol.62 (12), p.1667-1676 |
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| creator | So, Tiffany Y. Ai, Qi-Yong H. Lam, W. K. Jacky Qamar, Sahrish Poon, Darren M. C. Hui, Edwin P. Mo, Frankie K. F. Chan, K. C. Allen King, Ann D. |
| description | Purpose
Anatomical imaging criteria for the diagnosis of malignant head and neck nodes may not always be reliable. This study aimed to evaluate the diagnostic value of conventional diffusion-weighted imaging (DWI) and intravoxel incoherent motion (IVIM) DWI in discriminating benign and malignant metastatic retropharyngeal nodes (RPNs).
Methods
IVIM DWI using 14
b
-values was performed on RPNs of 30 patients with newly diagnosed metastatic nasopharyngeal carcinoma (NPC) and 30 patients with elevated plasma Epstein-Barr virus (EBV)-DNA without NPC who were part of an EBV-based NPC screening program. Histogram measurements of the two groups were compared for pure diffusion coefficient (
D
), pseudo-diffusion coefficient (
D
*), perfusion volume fraction (
f
) and apparent diffusion coefficient (
ADC
) using the Mann-Whitney
U
test. Area under the curves (AUCs) of significant measurements were calculated from receiver-operating characteristics analysis and compared using the DeLong test.
Results
Compared with metastatic RPNs, benign RPNs had lower
ADC
mean
(0.73 vs 0.82 × 10
−3
mm
2
/s) and
D
mean
(0.60 vs 0.71 × 10
−3
mm
2
/s) and a higher
D
*
mean
(35.21 vs 28.66 × 10
−3
mm
2
/s) (all
p
|
| doi_str_mv | 10.1007/s00234-020-02494-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2425000646</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2425000646</sourcerecordid><originalsourceid>FETCH-LOGICAL-c462t-d5a1eab6167d9df662b18b841d76a8bf8dfb60e64e220ec40234450c9711af1b3</originalsourceid><addsrcrecordid>eNp9kU9r3DAQxUVJINtNvkBOgl56caN_lu1jCW0SCOTSnoVsjbxabGkrebvpt8_sbqHQQw5CA_N7w8x7hNxy9oUz1twVxoRUFRMMn-pUdfhAVlxJUfFOsAuywn5byU6xK_KxlC1jTDayWZHXp7hk-zu9wkRDHNIGMsSFzmkJKVIXvN8XrKoDhHGzgKNhtmOII_UpY7sMOcwh2hOdPO0hhjFSGx2d7YSlxWEZlpx2G5v_xBHsRGNyUK7JpbdTgZu__5r8_P7tx_1j9fzy8HT_9bkalBZL5WrLwfaa68Z1zmstet72reKu0bbtfet8rxloBUIwGNTRBlWzoWs4t573ck0-n-fucvq1h7KYGbeGabIR0r4YoUSNbmilEf30H7pN-xxxO6QarmUt6yMlztSQUykZvNmhB3ic4cwcwzDnMAyGYU5hmAOK5FlUEEYX8r_R76jeAFhJj90</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471635356</pqid></control><display><type>article</type><title>Intravoxel incoherent motion diffusion-weighted imaging for discrimination of benign and malignant retropharyngeal nodes</title><source>SpringerNature Journals</source><creator>So, Tiffany Y. ; Ai, Qi-Yong H. ; Lam, W. K. Jacky ; Qamar, Sahrish ; Poon, Darren M. C. ; Hui, Edwin P. ; Mo, Frankie K. F. ; Chan, K. C. Allen ; King, Ann D.</creator><creatorcontrib>So, Tiffany Y. ; Ai, Qi-Yong H. ; Lam, W. K. Jacky ; Qamar, Sahrish ; Poon, Darren M. C. ; Hui, Edwin P. ; Mo, Frankie K. F. ; Chan, K. C. Allen ; King, Ann D.</creatorcontrib><description>Purpose
Anatomical imaging criteria for the diagnosis of malignant head and neck nodes may not always be reliable. This study aimed to evaluate the diagnostic value of conventional diffusion-weighted imaging (DWI) and intravoxel incoherent motion (IVIM) DWI in discriminating benign and malignant metastatic retropharyngeal nodes (RPNs).
Methods
IVIM DWI using 14
b
-values was performed on RPNs of 30 patients with newly diagnosed metastatic nasopharyngeal carcinoma (NPC) and 30 patients with elevated plasma Epstein-Barr virus (EBV)-DNA without NPC who were part of an EBV-based NPC screening program. Histogram measurements of the two groups were compared for pure diffusion coefficient (
D
), pseudo-diffusion coefficient (
D
*), perfusion volume fraction (
f
) and apparent diffusion coefficient (
ADC
) using the Mann-Whitney
U
test. Area under the curves (AUCs) of significant measurements were calculated from receiver-operating characteristics analysis and compared using the DeLong test.
Results
Compared with metastatic RPNs, benign RPNs had lower
ADC
mean
(0.73 vs 0.82 × 10
−3
mm
2
/s) and
D
mean
(0.60 vs 0.71 × 10
−3
mm
2
/s) and a higher
D
*
mean
(35.21 vs 28.66 × 10
−3
mm
2
/s) (all
p
< 0.05). There was no difference in the
f
measurements between the two groups (
p
= 0.204 to 0.301).
D
mean
achieved the highest AUC of 0.800, but this was not statistically better than the AUCs of the other parameters (
p
= 0.148 to 0.991).
Conclusion
Benign RPNs in patients with EBV-DNA showed greater restriction of diffusion compared with malignant metastatic RPNs from NPC. IVIM did not show a significant advantage over conventional DWI in discriminating benign and malignant nodes.</description><identifier>ISSN: 0028-3940</identifier><identifier>EISSN: 1432-1920</identifier><identifier>DOI: 10.1007/s00234-020-02494-w</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Benign ; Deoxyribonucleic acid ; Diagnostic systems ; Diffusion ; Diffusion coefficient ; DNA ; Epstein-Barr virus ; Head and neck ; Head-Neck-ENT Radiology ; Histograms ; Imaging ; Mathematical analysis ; Medical imaging ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Nasopharyngeal carcinoma ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Nodes ; Perfusion ; Radiology ; Throat cancer</subject><ispartof>Neuroradiology, 2020-12, Vol.62 (12), p.1667-1676</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-d5a1eab6167d9df662b18b841d76a8bf8dfb60e64e220ec40234450c9711af1b3</citedby><cites>FETCH-LOGICAL-c462t-d5a1eab6167d9df662b18b841d76a8bf8dfb60e64e220ec40234450c9711af1b3</cites><orcidid>0000-0002-1155-4389</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00234-020-02494-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00234-020-02494-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>So, Tiffany Y.</creatorcontrib><creatorcontrib>Ai, Qi-Yong H.</creatorcontrib><creatorcontrib>Lam, W. K. Jacky</creatorcontrib><creatorcontrib>Qamar, Sahrish</creatorcontrib><creatorcontrib>Poon, Darren M. C.</creatorcontrib><creatorcontrib>Hui, Edwin P.</creatorcontrib><creatorcontrib>Mo, Frankie K. F.</creatorcontrib><creatorcontrib>Chan, K. C. Allen</creatorcontrib><creatorcontrib>King, Ann D.</creatorcontrib><title>Intravoxel incoherent motion diffusion-weighted imaging for discrimination of benign and malignant retropharyngeal nodes</title><title>Neuroradiology</title><addtitle>Neuroradiology</addtitle><description>Purpose
Anatomical imaging criteria for the diagnosis of malignant head and neck nodes may not always be reliable. This study aimed to evaluate the diagnostic value of conventional diffusion-weighted imaging (DWI) and intravoxel incoherent motion (IVIM) DWI in discriminating benign and malignant metastatic retropharyngeal nodes (RPNs).
Methods
IVIM DWI using 14
b
-values was performed on RPNs of 30 patients with newly diagnosed metastatic nasopharyngeal carcinoma (NPC) and 30 patients with elevated plasma Epstein-Barr virus (EBV)-DNA without NPC who were part of an EBV-based NPC screening program. Histogram measurements of the two groups were compared for pure diffusion coefficient (
D
), pseudo-diffusion coefficient (
D
*), perfusion volume fraction (
f
) and apparent diffusion coefficient (
ADC
) using the Mann-Whitney
U
test. Area under the curves (AUCs) of significant measurements were calculated from receiver-operating characteristics analysis and compared using the DeLong test.
Results
Compared with metastatic RPNs, benign RPNs had lower
ADC
mean
(0.73 vs 0.82 × 10
−3
mm
2
/s) and
D
mean
(0.60 vs 0.71 × 10
−3
mm
2
/s) and a higher
D
*
mean
(35.21 vs 28.66 × 10
−3
mm
2
/s) (all
p
< 0.05). There was no difference in the
f
measurements between the two groups (
p
= 0.204 to 0.301).
D
mean
achieved the highest AUC of 0.800, but this was not statistically better than the AUCs of the other parameters (
p
= 0.148 to 0.991).
Conclusion
Benign RPNs in patients with EBV-DNA showed greater restriction of diffusion compared with malignant metastatic RPNs from NPC. IVIM did not show a significant advantage over conventional DWI in discriminating benign and malignant nodes.</description><subject>Benign</subject><subject>Deoxyribonucleic acid</subject><subject>Diagnostic systems</subject><subject>Diffusion</subject><subject>Diffusion coefficient</subject><subject>DNA</subject><subject>Epstein-Barr virus</subject><subject>Head and neck</subject><subject>Head-Neck-ENT Radiology</subject><subject>Histograms</subject><subject>Imaging</subject><subject>Mathematical analysis</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Nasopharyngeal carcinoma</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Nodes</subject><subject>Perfusion</subject><subject>Radiology</subject><subject>Throat cancer</subject><issn>0028-3940</issn><issn>1432-1920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU9r3DAQxUVJINtNvkBOgl56caN_lu1jCW0SCOTSnoVsjbxabGkrebvpt8_sbqHQQw5CA_N7w8x7hNxy9oUz1twVxoRUFRMMn-pUdfhAVlxJUfFOsAuywn5byU6xK_KxlC1jTDayWZHXp7hk-zu9wkRDHNIGMsSFzmkJKVIXvN8XrKoDhHGzgKNhtmOII_UpY7sMOcwh2hOdPO0hhjFSGx2d7YSlxWEZlpx2G5v_xBHsRGNyUK7JpbdTgZu__5r8_P7tx_1j9fzy8HT_9bkalBZL5WrLwfaa68Z1zmstet72reKu0bbtfet8rxloBUIwGNTRBlWzoWs4t573ck0-n-fucvq1h7KYGbeGabIR0r4YoUSNbmilEf30H7pN-xxxO6QarmUt6yMlztSQUykZvNmhB3ic4cwcwzDnMAyGYU5hmAOK5FlUEEYX8r_R76jeAFhJj90</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>So, Tiffany Y.</creator><creator>Ai, Qi-Yong H.</creator><creator>Lam, W. K. Jacky</creator><creator>Qamar, Sahrish</creator><creator>Poon, Darren M. C.</creator><creator>Hui, Edwin P.</creator><creator>Mo, Frankie K. F.</creator><creator>Chan, K. C. Allen</creator><creator>King, Ann D.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1155-4389</orcidid></search><sort><creationdate>20201201</creationdate><title>Intravoxel incoherent motion diffusion-weighted imaging for discrimination of benign and malignant retropharyngeal nodes</title><author>So, Tiffany Y. ; Ai, Qi-Yong H. ; Lam, W. K. Jacky ; Qamar, Sahrish ; Poon, Darren M. C. ; Hui, Edwin P. ; Mo, Frankie K. F. ; Chan, K. C. Allen ; King, Ann D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-d5a1eab6167d9df662b18b841d76a8bf8dfb60e64e220ec40234450c9711af1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Benign</topic><topic>Deoxyribonucleic acid</topic><topic>Diagnostic systems</topic><topic>Diffusion</topic><topic>Diffusion coefficient</topic><topic>DNA</topic><topic>Epstein-Barr virus</topic><topic>Head and neck</topic><topic>Head-Neck-ENT Radiology</topic><topic>Histograms</topic><topic>Imaging</topic><topic>Mathematical analysis</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Nasopharyngeal carcinoma</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Nodes</topic><topic>Perfusion</topic><topic>Radiology</topic><topic>Throat cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>So, Tiffany Y.</creatorcontrib><creatorcontrib>Ai, Qi-Yong H.</creatorcontrib><creatorcontrib>Lam, W. K. Jacky</creatorcontrib><creatorcontrib>Qamar, Sahrish</creatorcontrib><creatorcontrib>Poon, Darren M. C.</creatorcontrib><creatorcontrib>Hui, Edwin P.</creatorcontrib><creatorcontrib>Mo, Frankie K. F.</creatorcontrib><creatorcontrib>Chan, K. C. Allen</creatorcontrib><creatorcontrib>King, Ann D.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroradiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>So, Tiffany Y.</au><au>Ai, Qi-Yong H.</au><au>Lam, W. K. Jacky</au><au>Qamar, Sahrish</au><au>Poon, Darren M. C.</au><au>Hui, Edwin P.</au><au>Mo, Frankie K. F.</au><au>Chan, K. C. Allen</au><au>King, Ann D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intravoxel incoherent motion diffusion-weighted imaging for discrimination of benign and malignant retropharyngeal nodes</atitle><jtitle>Neuroradiology</jtitle><stitle>Neuroradiology</stitle><date>2020-12-01</date><risdate>2020</risdate><volume>62</volume><issue>12</issue><spage>1667</spage><epage>1676</epage><pages>1667-1676</pages><issn>0028-3940</issn><eissn>1432-1920</eissn><abstract>Purpose
Anatomical imaging criteria for the diagnosis of malignant head and neck nodes may not always be reliable. This study aimed to evaluate the diagnostic value of conventional diffusion-weighted imaging (DWI) and intravoxel incoherent motion (IVIM) DWI in discriminating benign and malignant metastatic retropharyngeal nodes (RPNs).
Methods
IVIM DWI using 14
b
-values was performed on RPNs of 30 patients with newly diagnosed metastatic nasopharyngeal carcinoma (NPC) and 30 patients with elevated plasma Epstein-Barr virus (EBV)-DNA without NPC who were part of an EBV-based NPC screening program. Histogram measurements of the two groups were compared for pure diffusion coefficient (
D
), pseudo-diffusion coefficient (
D
*), perfusion volume fraction (
f
) and apparent diffusion coefficient (
ADC
) using the Mann-Whitney
U
test. Area under the curves (AUCs) of significant measurements were calculated from receiver-operating characteristics analysis and compared using the DeLong test.
Results
Compared with metastatic RPNs, benign RPNs had lower
ADC
mean
(0.73 vs 0.82 × 10
−3
mm
2
/s) and
D
mean
(0.60 vs 0.71 × 10
−3
mm
2
/s) and a higher
D
*
mean
(35.21 vs 28.66 × 10
−3
mm
2
/s) (all
p
< 0.05). There was no difference in the
f
measurements between the two groups (
p
= 0.204 to 0.301).
D
mean
achieved the highest AUC of 0.800, but this was not statistically better than the AUCs of the other parameters (
p
= 0.148 to 0.991).
Conclusion
Benign RPNs in patients with EBV-DNA showed greater restriction of diffusion compared with malignant metastatic RPNs from NPC. IVIM did not show a significant advantage over conventional DWI in discriminating benign and malignant nodes.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00234-020-02494-w</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-1155-4389</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Neuroradiology, 2020-12, Vol.62 (12), p.1667-1676 |
| issn | 0028-3940 1432-1920 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2425000646 |
| source | SpringerNature Journals |
| subjects | Benign Deoxyribonucleic acid Diagnostic systems Diffusion Diffusion coefficient DNA Epstein-Barr virus Head and neck Head-Neck-ENT Radiology Histograms Imaging Mathematical analysis Medical imaging Medicine Medicine & Public Health Metastases Metastasis Nasopharyngeal carcinoma Neurology Neuroradiology Neurosciences Neurosurgery Nodes Perfusion Radiology Throat cancer |
| title | Intravoxel incoherent motion diffusion-weighted imaging for discrimination of benign and malignant retropharyngeal nodes |
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