Common gene variants in ASGR1 gene locus associate with reduced cardiovascular risk in absence of pleiotropic effects

The rare ASGR1 del12 variant is associated with a beneficial effect on coronary artery disease (CAD) that is disproportionate to the small reductions in plasma LDL cholesterol (LDLc). This unexplained benefit has sparked the debate on potential additional pleiotropic effects of ASGR1 variants. Since...

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Veröffentlicht in:	Atherosclerosis 2020-08, Vol.306, p.15-21
Hauptverfasser:	Ali, Lubna, Cupido, Arjen J., Rijkers, Maaike, Hovingh, G. Kees, Holleboom, Adriaan G., Dallinga-Thie, Geesje M., Stroes, Erik S.G., van den Boogert, Marjolein A.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	ASGR1 Cardiovascular disease LDL cholesterol Mendelian randomization Platelets
Online-Zugang:	Volltext
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