SARS-CoV-2 as a Factor to Disbalance the Renin-Angiotensin System: A Suspect in the Case of Exacerbated IL-6 Production

Fever in infections correlates with inflammation, macrophage infiltration into the affected organ, macrophage activation, and release of cytokines involved in immune response, hematopoiesis, and homeostatic processes. Angiotensin-converting enzyme 2 (ACE2) is the canonical cell surface receptor for...

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Veröffentlicht in:	The Journal of immunology (1950) 2020-09, Vol.205 (5), p.1198-1206
Hauptverfasser:	Franco, Rafael, Rivas-Santisteban, Rafael, Serrano-Marín, Joan, Rodríguez-Pérez, Ana I, Labandeira-García, José L, Navarro, Gemma
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin I - metabolism Angiotensin-Converting Enzyme 2 Animals Betacoronavirus - immunology Betacoronavirus - metabolism Coronavirus Infections - immunology Coronavirus Infections - virology COVID-19 Humans Inflammation - immunology Interleukin-6 - biosynthesis Macrophages - immunology Pandemics Peptide Fragments - metabolism Peptidyl-Dipeptidase A - metabolism Pneumonia, Viral - immunology Pneumonia, Viral - virology Proto-Oncogene Proteins - metabolism Receptor, Angiotensin, Type 1 - metabolism Receptor, Angiotensin, Type 2 - metabolism Receptors, G-Protein-Coupled - metabolism Receptors, Virus - metabolism Renin-Angiotensin System SARS-CoV-2
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