Amplified Detection of Breast Cancer Autoantibodies Using MUC1-Based Tn Antigen Mimics

In many human carcinomas, mucin-1 (MUC1) is overexpressed and aberrantly glycosylated, resulting in the exposure of previously hidden antigens. This generates new patient antibody profiles that can be used in cancer diagnosis. In the present study, we focused on the MUC1-associated Tn antigen (α-O-G...

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Veröffentlicht in:	Journal of medicinal chemistry 2020-08, Vol.63 (15), p.8524-8533
Hauptverfasser:	Guillen-Poza, Pablo A, Sánchez-Fernández, Elena M, Artigas, Gerard, García Fernández, José Manuel, Hinou, Hiroshi, Ortiz Mellet, Carmen, Nishimura, Shin-Ichiro, Garcia-Martin, Fayna
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Tumor-Associated, Carbohydrate - chemistry Antigens, Tumor-Associated, Carbohydrate - immunology Autoantibodies - blood Autoantibodies - immunology Breast Neoplasms - blood Breast Neoplasms - immunology Female Glycomics Humans Mucin-1 - chemistry Mucin-1 - immunology Peptide Library
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