Tailored Linker Chemistries for the Efficient and Selective Activation of ADCs with KSPi Payloads

Several antibody–drug conjugates (ADCs) have failed to achieve a sufficiently large therapeutic window in patients due to toxicity induced by unspecific payload release in the circulation or ADC uptake into healthy organs. Herein, we describe the successful engineering of ADCs consisting of novel li...

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Veröffentlicht in:	Bioconjugate chemistry 2020-08, Vol.31 (8), p.1893-1898
Hauptverfasser:	Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Sommer, Anette, Berndt, Sandra, Rebstock, Anne-Sophie, Johannes, Sarah, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Jörißen, Hannah
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Antibodies Asparagine Immunological tolerance Legumain Metabolites Organs Payloads Peptides Toxicity Tumors
Online-Zugang:	Volltext
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