Discovery of Novel Resorcinol Dibenzyl Ethers Targeting the Programmed Cell Death-1/Programmed Cell Death–Ligand 1 Interaction as Potential Anticancer Agents

Novel small molecule compounds based on various scaffolds including chalcone, flavonoid, and resorcinol dibenzyl ether were designed and tested for their inhibitory activity against the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 (PD-1/PD-L1) pathway. Among them, compound NP19 inhibited t...

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Veröffentlicht in:	Journal of medicinal chemistry 2020-08, Vol.63 (15), p.8338-8358
Hauptverfasser:	Cheng, Binbin, Ren, Yichang, Niu, Xiaoge, Wang, Wei, Wang, Shuanghu, Tu, Yingfeng, Liu, Shuwen, Wang, Jin, Yang, Deying, Liao, Guochao, Chen, Jianjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - metabolism Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Cell Line, Tumor Drug Discovery Humans Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Male Melanoma, Experimental - drug therapy Melanoma, Experimental - metabolism Mice Mice, Inbred BALB C Molecular Docking Simulation Phenyl Ethers - chemistry Phenyl Ethers - pharmacology Phenyl Ethers - therapeutic use Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - metabolism Protein Interaction Maps - drug effects Rats, Sprague-Dawley Resorcinols - chemistry Resorcinols - pharmacology Resorcinols - therapeutic use Signal Transduction - drug effects
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