Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway

Besides its role as the blueprint of life, DNA can also alert the cell to the presence of microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that triggers the innate immune response is cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase (...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2020-07, Vol.53 (1), p.43-53
Hauptverfasser:	Zhang, Xuewu, Bai, Xiao-chen, Chen, Zhijian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine monophosphate AMP Autophagy Binding sites Cell division Cellular structure Chromatin Cyclic GMP Cytokines Cytoplasm Dendritic cells Deoxyribonucleic acid Disease DNA DNA, Bacterial - immunology DNA, Viral - immunology Guanosine Humans Immune response Immune system Immunity Immunity, Innate - immunology Inflammatory diseases Innate immunity Interferon Interferon Type I - immunology Kinases Membrane Proteins - metabolism Microorganisms Mitochondria Mitochondrial DNA Mutation Nucleotides, Cyclic - metabolism Nucleotidyltransferases - metabolism Pathogens Phagocytosis Senescence Signal transduction Signal Transduction - immunology Stimulators Transcription factors
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