Intrinsic Efficacy of Opioid Ligands and Its Importance for Apparent Bias, Operational Analysis, and Therapeutic Window

Evidence from several novel opioid agonists and knockout animals suggests that improved opioid therapeutic window, notably for analgesia versus respiratory depression, is a result of ligand bias downstream of activation of the µ-opioid receptor (MOR) toward G protein signaling and away from other pa...

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Veröffentlicht in:	Molecular pharmacology 2020-10, Vol.98 (4), p.410-424
Hauptverfasser:	Gillis, Alexander, Sreenivasan, Varun, Christie, Macdonald J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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