Promiscuous Enzymes Cooperate at the Substrate Level En Route to Lactazole A

Enzymes involved in the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs) often have relaxed specificity profiles and are able to modify diverse substrates. When several such enzymes act together during precursor peptide maturation, a multitude of products ca...

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Veröffentlicht in:Journal of the American Chemical Society 2020-08, Vol.142 (32), p.13886-13897
Hauptverfasser: Vinogradov, Alexander A, Shimomura, Morito, Kano, Naokazu, Goto, Yuki, Onaka, Hiroyasu, Suga, Hiroaki
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Sprache:eng
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