Physiopharmacological properties of the testicular capsule: A concise review
The testicular capsules of different mammalian species exhibit spontaneous motor activity. In addition, contractions can be mediated by neuronal stimulation or exogenous drug administration. However, the physiological role of testicular capsule motor activity is still not well understood. Neverthele...
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| Veröffentlicht in: | European journal of pharmacology 2020-09, Vol.883, p.173345-173345, Article 173345 |
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| container_title | European journal of pharmacology |
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| creator | Jurkiewicz, Neide H. Jurkiewicz, Aron da Silva Júnior, Edilson Dantas |
| description | The testicular capsules of different mammalian species exhibit spontaneous motor activity. In addition, contractions can be mediated by neuronal stimulation or exogenous drug administration. However, the physiological role of testicular capsule motor activity is still not well understood. Nevertheless, there is evidence for putative roles in spermatozoa transport from the testis to the caput epididymis, control of interstitial/intratesticular pressure and testicular blood flow. In this review, we have collated information about the agents that regulate testicular capsule motor activity, their receptors and second messengers as well as the impact of altered testicular capsule function on the male reproductive system. Furthermore, we highlight the knowledge gaps in the physiology and pharmacology of the testicular capsule as indicators of future research directions that may lead to a better understanding of the physiological role of testicular capsule motor activity and its importance in male fertility.
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| doi_str_mv | 10.1016/j.ejphar.2020.173345 |
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[Display omitted]</description><subject>Animals</subject><subject>Autonomic Nervous System - drug effects</subject><subject>Autonomic Nervous System - physiology</subject><subject>Fertility - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Male reproductive system</subject><subject>Motor activity</subject><subject>Motor Activity - drug effects</subject><subject>Pharmacology</subject><subject>Physiology</subject><subject>Pressure</subject><subject>Regional Blood Flow</subject><subject>Reproduction - drug effects</subject><subject>Sperm Motility - drug effects</subject><subject>Testicular capsule</subject><subject>Testis - drug effects</subject><subject>Testis - innervation</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRtFb_gUiOXlJnP_LlQZDiFxT0oOdlM5naLWk37iaK_94tUY-ehhneeeedh7EzDjMOPL9cz2jdrYyfCRBxVEipsj024WVRpVBwsc8mAFyloqqqI3YcwhoAskpkh-xIijyXmYIJWzyvvoJ1O6ONQde6N4umTTrvOvK9pZC4ZdKvKOkp9BaH1vgETReGlq6SmwTdFm2gxNOHpc8TdrA0baDTnzplr3e3L_OHdPF0_zi_WaQoc9GnvBKFISAlS8XBSIXIi7pcKsOBpMxrKBWZsqkNNMrkhchqUyFUGBsoS5RTdjH6xpjvQwymNzYgta3ZkhuCFkpEY86LLErVKEXvQvC01J23G-O_NAe946jXeuSodxz1yDGunf9cGOoNNX9Lv-Ci4HoUUPwz_u51QEtbpMZ6wl43zv5_4Rt-qYXU</recordid><startdate>20200915</startdate><enddate>20200915</enddate><creator>Jurkiewicz, Neide H.</creator><creator>Jurkiewicz, Aron</creator><creator>da Silva Júnior, Edilson Dantas</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200915</creationdate><title>Physiopharmacological properties of the testicular capsule: A concise review</title><author>Jurkiewicz, Neide H. ; Jurkiewicz, Aron ; da Silva Júnior, Edilson Dantas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-1927ae0e438410a34cc17b8f4a10e336b084ea8dba0d4a6725ba9c09c4a6088c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Autonomic Nervous System - drug effects</topic><topic>Autonomic Nervous System - physiology</topic><topic>Fertility - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Male reproductive system</topic><topic>Motor activity</topic><topic>Motor Activity - drug effects</topic><topic>Pharmacology</topic><topic>Physiology</topic><topic>Pressure</topic><topic>Regional Blood Flow</topic><topic>Reproduction - drug effects</topic><topic>Sperm Motility - drug effects</topic><topic>Testicular capsule</topic><topic>Testis - drug effects</topic><topic>Testis - innervation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jurkiewicz, Neide H.</creatorcontrib><creatorcontrib>Jurkiewicz, Aron</creatorcontrib><creatorcontrib>da Silva Júnior, Edilson Dantas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jurkiewicz, Neide H.</au><au>Jurkiewicz, Aron</au><au>da Silva Júnior, Edilson Dantas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physiopharmacological properties of the testicular capsule: A concise review</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2020-09-15</date><risdate>2020</risdate><volume>883</volume><spage>173345</spage><epage>173345</epage><pages>173345-173345</pages><artnum>173345</artnum><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>The testicular capsules of different mammalian species exhibit spontaneous motor activity. In addition, contractions can be mediated by neuronal stimulation or exogenous drug administration. However, the physiological role of testicular capsule motor activity is still not well understood. Nevertheless, there is evidence for putative roles in spermatozoa transport from the testis to the caput epididymis, control of interstitial/intratesticular pressure and testicular blood flow. In this review, we have collated information about the agents that regulate testicular capsule motor activity, their receptors and second messengers as well as the impact of altered testicular capsule function on the male reproductive system. Furthermore, we highlight the knowledge gaps in the physiology and pharmacology of the testicular capsule as indicators of future research directions that may lead to a better understanding of the physiological role of testicular capsule motor activity and its importance in male fertility.
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| ispartof | European journal of pharmacology, 2020-09, Vol.883, p.173345-173345, Article 173345 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Autonomic Nervous System - drug effects Autonomic Nervous System - physiology Fertility - drug effects Humans Male Male reproductive system Motor activity Motor Activity - drug effects Pharmacology Physiology Pressure Regional Blood Flow Reproduction - drug effects Sperm Motility - drug effects Testicular capsule Testis - drug effects Testis - innervation |
| title | Physiopharmacological properties of the testicular capsule: A concise review |
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