Extracellular vesicle‐enclosed miR‐486‐5p mediates wound healing with adipose‐derived stem cells by promoting angiogenesis

Adipose‐derived stem cells (ASC) are said to have a pivotal role in wound healing. Specifically, ASC‐secreted extracellular vesicles (EV) carry diverse cargos such as microRNAs (miRNAs) to participate in the ASC‐based therapies. Considering its effects, we aimed to investigate the role of ASC‐EVs in...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-09, Vol.24 (17), p.9590-9604
Hauptverfasser:	Lu, Yingjie, Wen, Huicai, Huang, Jinjun, Liao, Peng, Liao, Huaiwei, Tu, Jun, Zeng, Yuanlin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - metabolism Adipocytes - pathology Adipose Tissue - metabolism Adipose Tissue - pathology adipose‐derived stem cells Adult Aged Angiogenesis Animal models Cell adhesion & migration Cell Biology Cells, Cultured Cholecystokinin Cicatrix - metabolism Cicatrix - pathology Collagen cutaneous wound Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Extracellular vesicles Extracellular Vesicles - metabolism Extracellular Vesicles - pathology Female Fibroblasts Fibroblasts - metabolism Fibroblasts - pathology Humans Immunofluorescence Life Sciences & Biomedicine Medicine, Research & Experimental MicroRNAs MicroRNAs - metabolism microRNA‐486‐5p Microscopy Microvasculature Middle Aged miRNA Mobility Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Original Plasmids Research & Experimental Medicine Science & Technology Skin Skin - metabolism Skin - pathology Stem cell transplantation Stem cells Stem Cells - metabolism Stem Cells - pathology Wound healing Wound Healing - physiology
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