Diminished expression of 5hmc in Reed-Sternberg cells in classical Hodgkin lymphoma is a common epigenetic marker

•5hmC is universally depleted in Reed-Sternberg cells.•Pharmacologic treatment with vitamin C induced apoptosis and replenished 5hmC content in a Hodgkin disease cell line.•Epigenetic therapies may be of benefit in classical Hodgkin lymphoma. Loss of the epigenetic marker 5-hydroxymethylcytosine (5h...

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Veröffentlicht in:	Leukemia research 2020-09, Vol.96, p.106408-106408, Article 106408
Hauptverfasser:	Siref, Andrew, McCormack, Colin, Huang, Qin, Lim, Washington, Alkan, Serhan
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - analogs & derivatives 5-Methylcytosine - metabolism Biomarkers - metabolism Classical Hodgkin lymphoma DNA Methylation Epigenesis, Genetic Epigenetics Hodgkin Disease - genetics Hodgkin Disease - pathology Hodgkin Disease - surgery Humans Methylation Reed-Sternberg Cells - metabolism Reed-Sternberg Cells - pathology vitamin C
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