Comparing two airway management strategies for moderately sedated patients undergoing awake craniotomy: A single‐blinded randomized controlled trial

Background In the monitored anesthesia care (MAC) setting for awake craniotomy (AC), maintaining airway patency in sedated patients remains challenging. This randomized controlled trial aimed to compare the validity of the below‐epiglottis transnasal tube insertion (the tip of the tube placed betwee...

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Veröffentlicht in:Acta anaesthesiologica Scandinavica 2020-11, Vol.64 (10), p.1414-1421
Hauptverfasser: Deng, Meng, Tu, Meng‐Yun, Liu, Yi‐Heng, Hu, Xiao‐Bing, Zhang, Tao, Wu, Jin‐Song, Wang, Ying‐Wei
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container_issue 10
container_start_page 1414
container_title Acta anaesthesiologica Scandinavica
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creator Deng, Meng
Tu, Meng‐Yun
Liu, Yi‐Heng
Hu, Xiao‐Bing
Zhang, Tao
Wu, Jin‐Song
Wang, Ying‐Wei
description Background In the monitored anesthesia care (MAC) setting for awake craniotomy (AC), maintaining airway patency in sedated patients remains challenging. This randomized controlled trial aimed to compare the validity of the below‐epiglottis transnasal tube insertion (the tip of the tube placed between the epiglottis and vocal cords) and the nasopharyngeal airway (simulated by the above‐epiglottis transnasal tube with the tip of the tube placed between the epiglottis and the free edge of the soft palate) with respect to maintaining upper airway patency for moderately sedated patients undergoing AC. Methods Sixty patients scheduled for elective AC were randomized to receive below‐epiglottis (n = 30) or above‐epiglottis (n = 30) transnasal tube insertion before surgery. Moderate sedation was maintained in the pre‐ and post‐awake phases. The primary outcome was the upper airway obstruction (UAO) remission rate (relieved obstructions after tube insertion/the total number of obstructions before tube insertion). Results The UAO remission rate was higher in the below‐epiglottis group [100% (12/12) vs 45% (5/11); P = .005]. The tidal volume values monitored through the tube were greater in the below‐epiglottis group during the pre‐awake phase (P 
doi_str_mv 10.1111/aas.13667
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This randomized controlled trial aimed to compare the validity of the below‐epiglottis transnasal tube insertion (the tip of the tube placed between the epiglottis and vocal cords) and the nasopharyngeal airway (simulated by the above‐epiglottis transnasal tube with the tip of the tube placed between the epiglottis and the free edge of the soft palate) with respect to maintaining upper airway patency for moderately sedated patients undergoing AC. Methods Sixty patients scheduled for elective AC were randomized to receive below‐epiglottis (n = 30) or above‐epiglottis (n = 30) transnasal tube insertion before surgery. Moderate sedation was maintained in the pre‐ and post‐awake phases. The primary outcome was the upper airway obstruction (UAO) remission rate (relieved obstructions after tube insertion/the total number of obstructions before tube insertion). Results The UAO remission rate was higher in the below‐epiglottis group [100% (12/12) vs 45% (5/11); P = .005]. The tidal volume values monitored through the tube were greater in the below‐epiglottis group during the pre‐awake phase (P &lt; .001). End‐tidal carbon dioxide (EtCO2) monitored through the tube was higher in the below‐epiglottis group at bone flap removal (P &lt; .001). During the awake phase, patients' ability to speak was not impeded. No patient had serious complications related to the tube. Conclusion The below‐epiglottis tube insertion is a more effective method to maintain upper airway patency than the nasopharyngeal airway for moderately sedated patients undergoing AC.</description><identifier>ISSN: 0001-5172</identifier><identifier>EISSN: 1399-6576</identifier><identifier>DOI: 10.1111/aas.13667</identifier><identifier>PMID: 32659854</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Airway management ; Anesthesia ; Carbon dioxide ; Clinical trials ; Complications ; Epiglottis ; Insertion ; Obstructions ; Palate ; Remission ; Respiratory tract ; Surgery ; Vocal cords</subject><ispartof>Acta anaesthesiologica Scandinavica, 2020-11, Vol.64 (10), p.1414-1421</ispartof><rights>2020 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley &amp; Sons Ltd</rights><rights>2020 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley &amp; Sons Ltd.</rights><rights>Copyright © 2020 The Acta Anaesthesiologica Scandinavica Foundation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3537-caa0cc5a6a6eabbaf2ec6ad7333c39033fcdd0677c6799115f2bf4da925580063</citedby><cites>FETCH-LOGICAL-c3537-caa0cc5a6a6eabbaf2ec6ad7333c39033fcdd0677c6799115f2bf4da925580063</cites><orcidid>0000-0002-2554-6611 ; 0000-0002-7778-2368 ; 0000-0002-1484-3039</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faas.13667$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faas.13667$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32659854$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, Meng</creatorcontrib><creatorcontrib>Tu, Meng‐Yun</creatorcontrib><creatorcontrib>Liu, Yi‐Heng</creatorcontrib><creatorcontrib>Hu, Xiao‐Bing</creatorcontrib><creatorcontrib>Zhang, Tao</creatorcontrib><creatorcontrib>Wu, Jin‐Song</creatorcontrib><creatorcontrib>Wang, Ying‐Wei</creatorcontrib><title>Comparing two airway management strategies for moderately sedated patients undergoing awake craniotomy: A single‐blinded randomized controlled trial</title><title>Acta anaesthesiologica Scandinavica</title><addtitle>Acta Anaesthesiol Scand</addtitle><description>Background In the monitored anesthesia care (MAC) setting for awake craniotomy (AC), maintaining airway patency in sedated patients remains challenging. This randomized controlled trial aimed to compare the validity of the below‐epiglottis transnasal tube insertion (the tip of the tube placed between the epiglottis and vocal cords) and the nasopharyngeal airway (simulated by the above‐epiglottis transnasal tube with the tip of the tube placed between the epiglottis and the free edge of the soft palate) with respect to maintaining upper airway patency for moderately sedated patients undergoing AC. Methods Sixty patients scheduled for elective AC were randomized to receive below‐epiglottis (n = 30) or above‐epiglottis (n = 30) transnasal tube insertion before surgery. Moderate sedation was maintained in the pre‐ and post‐awake phases. The primary outcome was the upper airway obstruction (UAO) remission rate (relieved obstructions after tube insertion/the total number of obstructions before tube insertion). Results The UAO remission rate was higher in the below‐epiglottis group [100% (12/12) vs 45% (5/11); P = .005]. The tidal volume values monitored through the tube were greater in the below‐epiglottis group during the pre‐awake phase (P &lt; .001). End‐tidal carbon dioxide (EtCO2) monitored through the tube was higher in the below‐epiglottis group at bone flap removal (P &lt; .001). During the awake phase, patients' ability to speak was not impeded. No patient had serious complications related to the tube. Conclusion The below‐epiglottis tube insertion is a more effective method to maintain upper airway patency than the nasopharyngeal airway for moderately sedated patients undergoing AC.</description><subject>Airway management</subject><subject>Anesthesia</subject><subject>Carbon dioxide</subject><subject>Clinical trials</subject><subject>Complications</subject><subject>Epiglottis</subject><subject>Insertion</subject><subject>Obstructions</subject><subject>Palate</subject><subject>Remission</subject><subject>Respiratory tract</subject><subject>Surgery</subject><subject>Vocal cords</subject><issn>0001-5172</issn><issn>1399-6576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kcGOFCEURYnROD2jC3_AkLjRRc1AUUDjrtPR0WQSF-q68gqoDiMULVDp1Kz8BFd-oF8ibY8uTGTDg3ty8pKL0DNKLmk9VwD5kjIh5AO0okypRnApHqIVIYQ2nMr2DJ3nfFufrFPqMTpjreBqzbsV-rGNYQ_JTTtcDhGDSwdYcIAJdjbYqeBcEhS7czbjMSYcorHHD7_gbE0dDN5DcZXMeJ5qtotHFxzgi8U6weRiiWF5jTc418Dbn9--D95V0uCamhjcXR11nEqK3texJAf-CXo0gs_26f19gT6_ffNp-665-XD9fru5aTTjTDYagGjNQYCwMAwwtlYLMJIxppkijI3aGCKk1EIqRSkf22HsDKiW8zUhgl2glyfvPsWvs82lDy5r6z1MNs65b7uWrUnH6LqiL_5Bb-OcprpdpTpVQcmOwlcnSqeYc7Jjv08uQFp6SvpjWX0tq_9dVmWf3xvnIVjzl_zTTgWuTsDBebv839RvNh9Pyl8w-KLh</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Deng, Meng</creator><creator>Tu, Meng‐Yun</creator><creator>Liu, Yi‐Heng</creator><creator>Hu, Xiao‐Bing</creator><creator>Zhang, Tao</creator><creator>Wu, Jin‐Song</creator><creator>Wang, Ying‐Wei</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2554-6611</orcidid><orcidid>https://orcid.org/0000-0002-7778-2368</orcidid><orcidid>https://orcid.org/0000-0002-1484-3039</orcidid></search><sort><creationdate>202011</creationdate><title>Comparing two airway management strategies for moderately sedated patients undergoing awake craniotomy: A single‐blinded randomized controlled trial</title><author>Deng, Meng ; Tu, Meng‐Yun ; Liu, Yi‐Heng ; Hu, Xiao‐Bing ; Zhang, Tao ; Wu, Jin‐Song ; Wang, Ying‐Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3537-caa0cc5a6a6eabbaf2ec6ad7333c39033fcdd0677c6799115f2bf4da925580063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Airway management</topic><topic>Anesthesia</topic><topic>Carbon dioxide</topic><topic>Clinical trials</topic><topic>Complications</topic><topic>Epiglottis</topic><topic>Insertion</topic><topic>Obstructions</topic><topic>Palate</topic><topic>Remission</topic><topic>Respiratory tract</topic><topic>Surgery</topic><topic>Vocal cords</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deng, Meng</creatorcontrib><creatorcontrib>Tu, Meng‐Yun</creatorcontrib><creatorcontrib>Liu, Yi‐Heng</creatorcontrib><creatorcontrib>Hu, Xiao‐Bing</creatorcontrib><creatorcontrib>Zhang, Tao</creatorcontrib><creatorcontrib>Wu, Jin‐Song</creatorcontrib><creatorcontrib>Wang, Ying‐Wei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta anaesthesiologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, Meng</au><au>Tu, Meng‐Yun</au><au>Liu, Yi‐Heng</au><au>Hu, Xiao‐Bing</au><au>Zhang, Tao</au><au>Wu, Jin‐Song</au><au>Wang, Ying‐Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparing two airway management strategies for moderately sedated patients undergoing awake craniotomy: A single‐blinded randomized controlled trial</atitle><jtitle>Acta anaesthesiologica Scandinavica</jtitle><addtitle>Acta Anaesthesiol Scand</addtitle><date>2020-11</date><risdate>2020</risdate><volume>64</volume><issue>10</issue><spage>1414</spage><epage>1421</epage><pages>1414-1421</pages><issn>0001-5172</issn><eissn>1399-6576</eissn><abstract>Background In the monitored anesthesia care (MAC) setting for awake craniotomy (AC), maintaining airway patency in sedated patients remains challenging. This randomized controlled trial aimed to compare the validity of the below‐epiglottis transnasal tube insertion (the tip of the tube placed between the epiglottis and vocal cords) and the nasopharyngeal airway (simulated by the above‐epiglottis transnasal tube with the tip of the tube placed between the epiglottis and the free edge of the soft palate) with respect to maintaining upper airway patency for moderately sedated patients undergoing AC. Methods Sixty patients scheduled for elective AC were randomized to receive below‐epiglottis (n = 30) or above‐epiglottis (n = 30) transnasal tube insertion before surgery. Moderate sedation was maintained in the pre‐ and post‐awake phases. The primary outcome was the upper airway obstruction (UAO) remission rate (relieved obstructions after tube insertion/the total number of obstructions before tube insertion). Results The UAO remission rate was higher in the below‐epiglottis group [100% (12/12) vs 45% (5/11); P = .005]. The tidal volume values monitored through the tube were greater in the below‐epiglottis group during the pre‐awake phase (P &lt; .001). End‐tidal carbon dioxide (EtCO2) monitored through the tube was higher in the below‐epiglottis group at bone flap removal (P &lt; .001). During the awake phase, patients' ability to speak was not impeded. No patient had serious complications related to the tube. Conclusion The below‐epiglottis tube insertion is a more effective method to maintain upper airway patency than the nasopharyngeal airway for moderately sedated patients undergoing AC.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32659854</pmid><doi>10.1111/aas.13667</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2554-6611</orcidid><orcidid>https://orcid.org/0000-0002-7778-2368</orcidid><orcidid>https://orcid.org/0000-0002-1484-3039</orcidid></addata></record>
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subjects Airway management
Anesthesia
Carbon dioxide
Clinical trials
Complications
Epiglottis
Insertion
Obstructions
Palate
Remission
Respiratory tract
Surgery
Vocal cords
title Comparing two airway management strategies for moderately sedated patients undergoing awake craniotomy: A single‐blinded randomized controlled trial
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