A Preliminary Study of Adjunctive Nonconvulsive Electrotherapy for Treatment-Refractory Depression
Nonconvulsive electrotherapy (NET) defined as electrical brain stimulation administered like standard electroconvulsive therapy (ECT), but below seizure threshold, could be effective for patients with treatment-refractory depression (TRD) with fewer adverse neurocognitive outcomes. However, there is...
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| Veröffentlicht in: | Psychiatric quarterly 2021-03, Vol.92 (1), p.311-320 |
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| container_title | Psychiatric quarterly |
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| creator | Zheng, Wei Jiang, Miao-Ling He, Hong-Bo Li, Ri-Peng Li, Qi-Long Zhang, Chun-Ping Zhou, Su-Miao Yan, Su Ning, Yu-Ping Huang, Xiong |
| description | Nonconvulsive electrotherapy (NET) defined as electrical brain stimulation administered like standard electroconvulsive therapy (ECT), but below seizure threshold, could be effective for patients with treatment-refractory depression (TRD) with fewer adverse neurocognitive outcomes. However, there is a lack of studies in Chinese patients with TRD. Thus, this study was conducted to examine the efficacy and safety of adjunctive NET for Chinese patients with TRD. Twenty TRD patients were enrolled and underwent six NET treatments. Depressive symptoms, response, and remission were assessed with the 17-item Hamilton Depression Rating Scale (HAMD-17) at baseline and after 1, 3, and 6 NET treatments. Neurocognitive function was assessed by the Wisconsin Card Sorting Test (WCST) at baseline and after the completion of six NET treatments. Mean HAMD-17 scores declined significantly from 26.2 to 10.4 (
p
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| doi_str_mv | 10.1007/s11126-020-09798-3 |
| format | Article |
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p
< 0.001) after post-NET. The rates of response and remission were 60.0% (95% CI: 36.5–83.5) and 10.0% (95% CI: 0–24.4), respectively. Neurocognitive performance improved following a course of NET. No significant association was found between changes in depressive symptoms and baseline neurocognitive function. Adjunctive NET appeared to be effective for patients with TRD, without adverse neurocognitive effects. Randomized controlled studies were warranted to confirm these findings.</description><identifier>ISSN: 0033-2720</identifier><identifier>EISSN: 1573-6709</identifier><identifier>DOI: 10.1007/s11126-020-09798-3</identifier><identifier>PMID: 32661940</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Clinical outcomes ; Cognition ; Convulsions & seizures ; Depressive Disorder, Treatment-Resistant - therapy ; Efficacy ; Electric Stimulation Therapy ; Electrical stimulation of the brain ; Electroconvulsive therapy ; ESB ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Mental depression ; Original Paper ; Psychiatry ; Public Health ; Refractory depression ; Remission ; Remission (Medicine) ; Sociology ; Stimulation</subject><ispartof>Psychiatric quarterly, 2021-03, Vol.92 (1), p.311-320</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-ec382e8665f8fc87fb1e811934e900d2c3a465c62a1db556e0228782296903663</citedby><cites>FETCH-LOGICAL-c375t-ec382e8665f8fc87fb1e811934e900d2c3a465c62a1db556e0228782296903663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11126-020-09798-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11126-020-09798-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,12845,27923,27924,30998,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32661940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Wei</creatorcontrib><creatorcontrib>Jiang, Miao-Ling</creatorcontrib><creatorcontrib>He, Hong-Bo</creatorcontrib><creatorcontrib>Li, Ri-Peng</creatorcontrib><creatorcontrib>Li, Qi-Long</creatorcontrib><creatorcontrib>Zhang, Chun-Ping</creatorcontrib><creatorcontrib>Zhou, Su-Miao</creatorcontrib><creatorcontrib>Yan, Su</creatorcontrib><creatorcontrib>Ning, Yu-Ping</creatorcontrib><creatorcontrib>Huang, Xiong</creatorcontrib><title>A Preliminary Study of Adjunctive Nonconvulsive Electrotherapy for Treatment-Refractory Depression</title><title>Psychiatric quarterly</title><addtitle>Psychiatr Q</addtitle><addtitle>Psychiatr Q</addtitle><description>Nonconvulsive electrotherapy (NET) defined as electrical brain stimulation administered like standard electroconvulsive therapy (ECT), but below seizure threshold, could be effective for patients with treatment-refractory depression (TRD) with fewer adverse neurocognitive outcomes. However, there is a lack of studies in Chinese patients with TRD. Thus, this study was conducted to examine the efficacy and safety of adjunctive NET for Chinese patients with TRD. Twenty TRD patients were enrolled and underwent six NET treatments. Depressive symptoms, response, and remission were assessed with the 17-item Hamilton Depression Rating Scale (HAMD-17) at baseline and after 1, 3, and 6 NET treatments. Neurocognitive function was assessed by the Wisconsin Card Sorting Test (WCST) at baseline and after the completion of six NET treatments. Mean HAMD-17 scores declined significantly from 26.2 to 10.4 (
p
< 0.001) after post-NET. The rates of response and remission were 60.0% (95% CI: 36.5–83.5) and 10.0% (95% CI: 0–24.4), respectively. Neurocognitive performance improved following a course of NET. No significant association was found between changes in depressive symptoms and baseline neurocognitive function. Adjunctive NET appeared to be effective for patients with TRD, without adverse neurocognitive effects. Randomized controlled studies were warranted to confirm these findings.</description><subject>Adult</subject><subject>Clinical outcomes</subject><subject>Cognition</subject><subject>Convulsions & seizures</subject><subject>Depressive Disorder, Treatment-Resistant - therapy</subject><subject>Efficacy</subject><subject>Electric Stimulation Therapy</subject><subject>Electrical stimulation of the brain</subject><subject>Electroconvulsive therapy</subject><subject>ESB</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental depression</subject><subject>Original Paper</subject><subject>Psychiatry</subject><subject>Public Health</subject><subject>Refractory depression</subject><subject>Remission</subject><subject>Remission (Medicine)</subject><subject>Sociology</subject><subject>Stimulation</subject><issn>0033-2720</issn><issn>1573-6709</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU1vFDEMhiNERZfCH-CARuLCJeA4O_k4rkr5kCpaQTlHsxkPzGomWZJMpf33TdkCEgdOluXHr633ZeyFgDcCQL_NQghUHBA4WG0Nl4_YSrRacqXBPmYrACk5aoRT9jTnHYAQSuITdipRKWHXsGLbTXOdaBrnMXTp0HwtS39o4tBs-t0SfBlvqfkcg4_hdpnyfXcxkS8plh-Uuv2hGWJqbhJ1ZaZQ-BcaUudLrErvaJ8o5zGGZ-xk6KZMzx_qGfv2_uLm_CO_vPrw6Xxzyb3UbeHkpUEySrWDGbzRw1aQEcLKNVmAHr3s1qr1CjvRb9tWESAabRCtsiCVkmfs9VF3n-LPhXJx85g9TVMXKC7Z4RqlAbBSVPTVP-guLinU7yplUVupBFYKj5RPMedEg9unca42OQHuPgF3TMDVBNyvBJysSy8fpJftTP2fld-WV0AegVxH4Tulv7f_I3sHG4qQug</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Zheng, Wei</creator><creator>Jiang, Miao-Ling</creator><creator>He, Hong-Bo</creator><creator>Li, Ri-Peng</creator><creator>Li, Qi-Long</creator><creator>Zhang, Chun-Ping</creator><creator>Zhou, Su-Miao</creator><creator>Yan, Su</creator><creator>Ning, Yu-Ping</creator><creator>Huang, Xiong</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2S</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20210301</creationdate><title>A Preliminary Study of Adjunctive Nonconvulsive Electrotherapy for Treatment-Refractory Depression</title><author>Zheng, Wei ; Jiang, Miao-Ling ; He, Hong-Bo ; Li, Ri-Peng ; Li, Qi-Long ; Zhang, Chun-Ping ; Zhou, Su-Miao ; Yan, Su ; Ning, Yu-Ping ; Huang, Xiong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-ec382e8665f8fc87fb1e811934e900d2c3a465c62a1db556e0228782296903663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Clinical outcomes</topic><topic>Cognition</topic><topic>Convulsions & seizures</topic><topic>Depressive Disorder, Treatment-Resistant - therapy</topic><topic>Efficacy</topic><topic>Electric Stimulation Therapy</topic><topic>Electrical stimulation of the brain</topic><topic>Electroconvulsive therapy</topic><topic>ESB</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental depression</topic><topic>Original Paper</topic><topic>Psychiatry</topic><topic>Public Health</topic><topic>Refractory depression</topic><topic>Remission</topic><topic>Remission (Medicine)</topic><topic>Sociology</topic><topic>Stimulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Wei</creatorcontrib><creatorcontrib>Jiang, Miao-Ling</creatorcontrib><creatorcontrib>He, Hong-Bo</creatorcontrib><creatorcontrib>Li, Ri-Peng</creatorcontrib><creatorcontrib>Li, Qi-Long</creatorcontrib><creatorcontrib>Zhang, Chun-Ping</creatorcontrib><creatorcontrib>Zhou, Su-Miao</creatorcontrib><creatorcontrib>Yan, Su</creatorcontrib><creatorcontrib>Ning, Yu-Ping</creatorcontrib><creatorcontrib>Huang, Xiong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Sociology Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatric quarterly</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Wei</au><au>Jiang, Miao-Ling</au><au>He, Hong-Bo</au><au>Li, Ri-Peng</au><au>Li, Qi-Long</au><au>Zhang, Chun-Ping</au><au>Zhou, Su-Miao</au><au>Yan, Su</au><au>Ning, Yu-Ping</au><au>Huang, Xiong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Preliminary Study of Adjunctive Nonconvulsive Electrotherapy for Treatment-Refractory Depression</atitle><jtitle>Psychiatric quarterly</jtitle><stitle>Psychiatr Q</stitle><addtitle>Psychiatr Q</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>92</volume><issue>1</issue><spage>311</spage><epage>320</epage><pages>311-320</pages><issn>0033-2720</issn><eissn>1573-6709</eissn><abstract>Nonconvulsive electrotherapy (NET) defined as electrical brain stimulation administered like standard electroconvulsive therapy (ECT), but below seizure threshold, could be effective for patients with treatment-refractory depression (TRD) with fewer adverse neurocognitive outcomes. However, there is a lack of studies in Chinese patients with TRD. Thus, this study was conducted to examine the efficacy and safety of adjunctive NET for Chinese patients with TRD. Twenty TRD patients were enrolled and underwent six NET treatments. Depressive symptoms, response, and remission were assessed with the 17-item Hamilton Depression Rating Scale (HAMD-17) at baseline and after 1, 3, and 6 NET treatments. Neurocognitive function was assessed by the Wisconsin Card Sorting Test (WCST) at baseline and after the completion of six NET treatments. Mean HAMD-17 scores declined significantly from 26.2 to 10.4 (
p
< 0.001) after post-NET. The rates of response and remission were 60.0% (95% CI: 36.5–83.5) and 10.0% (95% CI: 0–24.4), respectively. Neurocognitive performance improved following a course of NET. No significant association was found between changes in depressive symptoms and baseline neurocognitive function. Adjunctive NET appeared to be effective for patients with TRD, without adverse neurocognitive effects. Randomized controlled studies were warranted to confirm these findings.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32661940</pmid><doi>10.1007/s11126-020-09798-3</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Clinical outcomes Cognition Convulsions & seizures Depressive Disorder, Treatment-Resistant - therapy Efficacy Electric Stimulation Therapy Electrical stimulation of the brain Electroconvulsive therapy ESB Female Humans Male Medicine Medicine & Public Health Mental depression Original Paper Psychiatry Public Health Refractory depression Remission Remission (Medicine) Sociology Stimulation |
| title | A Preliminary Study of Adjunctive Nonconvulsive Electrotherapy for Treatment-Refractory Depression |
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