RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata
Up-regulation of MMP-2 and MMP-9 plays a significant role in promoting cancer progression by degrading the components of the extracellular matrix, thereby enhancing the migration of tumor cells. Although the anti-proliferative and apoptotic effect of Annona muricata is well established, its effect o...
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| Veröffentlicht in: | Journal of biosciences 2020-12, Vol.45 (1), Article 89 |
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| creator | Drishya, G Nambiar, Jyotsna Shaji, Sanu K Vanuopadath, Muralidharan Achuthan, A Kumar, Abishek Alias, Ashna Sherif, Ayesha Joseph, Catherine Divya, P Kumar, Damu Sunil Bose, Chinchu Nair, Sobha Vijayan Sudarslal, S Kumar, Geetha B Lakshmi, S Nair, Bipin G |
| description | Up-regulation of MMP-2 and MMP-9 plays a significant role in promoting cancer progression by degrading the components of the extracellular matrix, thereby enhancing the migration of tumor cells. Although the anti-proliferative and apoptotic effect of
Annona muricata
is well established, its effect on MMP-2 and MMP-9, a major target in several types of cancers, has not been studied. Powdered samples of various parts of
A. muricata
like fruit, stem, seed, and twig extracted using aqueous methanol showed significant dose-dependent inhibition of MMP-2 and MMP-9 in a highly metastatic fibrosarcoma cell line, HT1080. Additionally, these extracts also up-regulated the expression of several endogenous inhibitors of MMP-2 and MMP-9 like REversion-inducing Cysteine-rich protein with Kazal motifs (RECK) and Tissue Inhibitor of Metalloproteinase-2 (TIMP-2). Furthermore, primary cells developed from tumor tissues obtained from patients not exposed to chemotherapy, also exhibited similar results. Remarkably, the inhibition of MMP-2 and MMP-9 observed was tumor specific, with the
A. muricata
fruit extract showing only 2% inhibition in cells obtained from normal tissues, when compared to 60% inhibition observed in cells obtained from tumor samples. The present study elucidates a novel mechanism by which
A. muricata
extracts selectively exhibit their anti-cancer activity in tumor cells by down-regulating MMP-2 and MMP-9 that are important biomarkers in cancer. |
| doi_str_mv | 10.1007/s12038-020-00056-z |
| format | Article |
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Annona muricata
is well established, its effect on MMP-2 and MMP-9, a major target in several types of cancers, has not been studied. Powdered samples of various parts of
A. muricata
like fruit, stem, seed, and twig extracted using aqueous methanol showed significant dose-dependent inhibition of MMP-2 and MMP-9 in a highly metastatic fibrosarcoma cell line, HT1080. Additionally, these extracts also up-regulated the expression of several endogenous inhibitors of MMP-2 and MMP-9 like REversion-inducing Cysteine-rich protein with Kazal motifs (RECK) and Tissue Inhibitor of Metalloproteinase-2 (TIMP-2). Furthermore, primary cells developed from tumor tissues obtained from patients not exposed to chemotherapy, also exhibited similar results. Remarkably, the inhibition of MMP-2 and MMP-9 observed was tumor specific, with the
A. muricata
fruit extract showing only 2% inhibition in cells obtained from normal tissues, when compared to 60% inhibition observed in cells obtained from tumor samples. The present study elucidates a novel mechanism by which
A. muricata
extracts selectively exhibit their anti-cancer activity in tumor cells by down-regulating MMP-2 and MMP-9 that are important biomarkers in cancer.</description><identifier>ISSN: 0250-5991</identifier><identifier>EISSN: 0973-7138</identifier><identifier>DOI: 10.1007/s12038-020-00056-z</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Annona muricata ; Anticancer properties ; Apoptosis ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Cell Biology ; Cell migration ; Chemotherapy ; Extracellular ; Extracellular matrix ; Fibrosarcoma ; Fruits ; Gelatinase A ; Gelatinase B ; Life Sciences ; Matrix metalloproteinases ; Metalloproteinase ; Metastases ; Microbiology ; Neoplasms ; Plant Sciences ; Reversion ; Tissue ; Tissue inhibitor of metalloproteinase 2 ; Tumor cells ; Tumors ; Zoology</subject><ispartof>Journal of biosciences, 2020-12, Vol.45 (1), Article 89</ispartof><rights>Indian Academy of Sciences 2020</rights><rights>Indian Academy of Sciences 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-bf5d30f286913c3e7b9da8f7c15a566d3c18caece8b18eca1d785a5fa02d054c3</citedby><cites>FETCH-LOGICAL-c380t-bf5d30f286913c3e7b9da8f7c15a566d3c18caece8b18eca1d785a5fa02d054c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12038-020-00056-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12038-020-00056-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Drishya, G</creatorcontrib><creatorcontrib>Nambiar, Jyotsna</creatorcontrib><creatorcontrib>Shaji, Sanu K</creatorcontrib><creatorcontrib>Vanuopadath, Muralidharan</creatorcontrib><creatorcontrib>Achuthan, A</creatorcontrib><creatorcontrib>Kumar, Abishek</creatorcontrib><creatorcontrib>Alias, Ashna</creatorcontrib><creatorcontrib>Sherif, Ayesha</creatorcontrib><creatorcontrib>Joseph, Catherine</creatorcontrib><creatorcontrib>Divya, P</creatorcontrib><creatorcontrib>Kumar, Damu Sunil</creatorcontrib><creatorcontrib>Bose, Chinchu</creatorcontrib><creatorcontrib>Nair, Sobha Vijayan</creatorcontrib><creatorcontrib>Sudarslal, S</creatorcontrib><creatorcontrib>Kumar, Geetha B</creatorcontrib><creatorcontrib>Lakshmi, S</creatorcontrib><creatorcontrib>Nair, Bipin G</creatorcontrib><title>RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata</title><title>Journal of biosciences</title><addtitle>J Biosci</addtitle><description>Up-regulation of MMP-2 and MMP-9 plays a significant role in promoting cancer progression by degrading the components of the extracellular matrix, thereby enhancing the migration of tumor cells. Although the anti-proliferative and apoptotic effect of
Annona muricata
is well established, its effect on MMP-2 and MMP-9, a major target in several types of cancers, has not been studied. Powdered samples of various parts of
A. muricata
like fruit, stem, seed, and twig extracted using aqueous methanol showed significant dose-dependent inhibition of MMP-2 and MMP-9 in a highly metastatic fibrosarcoma cell line, HT1080. Additionally, these extracts also up-regulated the expression of several endogenous inhibitors of MMP-2 and MMP-9 like REversion-inducing Cysteine-rich protein with Kazal motifs (RECK) and Tissue Inhibitor of Metalloproteinase-2 (TIMP-2). Furthermore, primary cells developed from tumor tissues obtained from patients not exposed to chemotherapy, also exhibited similar results. Remarkably, the inhibition of MMP-2 and MMP-9 observed was tumor specific, with the
A. muricata
fruit extract showing only 2% inhibition in cells obtained from normal tissues, when compared to 60% inhibition observed in cells obtained from tumor samples. The present study elucidates a novel mechanism by which
A. muricata
extracts selectively exhibit their anti-cancer activity in tumor cells by down-regulating MMP-2 and MMP-9 that are important biomarkers in cancer.</description><subject>Annona muricata</subject><subject>Anticancer properties</subject><subject>Apoptosis</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Cell Biology</subject><subject>Cell migration</subject><subject>Chemotherapy</subject><subject>Extracellular</subject><subject>Extracellular matrix</subject><subject>Fibrosarcoma</subject><subject>Fruits</subject><subject>Gelatinase A</subject><subject>Gelatinase B</subject><subject>Life Sciences</subject><subject>Matrix metalloproteinases</subject><subject>Metalloproteinase</subject><subject>Metastases</subject><subject>Microbiology</subject><subject>Neoplasms</subject><subject>Plant Sciences</subject><subject>Reversion</subject><subject>Tissue</subject><subject>Tissue inhibitor of 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and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata</title><author>Drishya, G ; Nambiar, Jyotsna ; Shaji, Sanu K ; Vanuopadath, Muralidharan ; Achuthan, A ; Kumar, Abishek ; Alias, Ashna ; Sherif, Ayesha ; Joseph, Catherine ; Divya, P ; Kumar, Damu Sunil ; Bose, Chinchu ; Nair, Sobha Vijayan ; Sudarslal, S ; Kumar, Geetha B ; Lakshmi, S ; Nair, Bipin G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-bf5d30f286913c3e7b9da8f7c15a566d3c18caece8b18eca1d785a5fa02d054c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Annona muricata</topic><topic>Anticancer properties</topic><topic>Apoptosis</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer</topic><topic>Cell Biology</topic><topic>Cell migration</topic><topic>Chemotherapy</topic><topic>Extracellular</topic><topic>Extracellular 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MMP-2 and MMP-9 by Annona muricata</atitle><jtitle>Journal of biosciences</jtitle><stitle>J Biosci</stitle><date>2020-12-01</date><risdate>2020</risdate><volume>45</volume><issue>1</issue><artnum>89</artnum><issn>0250-5991</issn><eissn>0973-7138</eissn><abstract>Up-regulation of MMP-2 and MMP-9 plays a significant role in promoting cancer progression by degrading the components of the extracellular matrix, thereby enhancing the migration of tumor cells. Although the anti-proliferative and apoptotic effect of
Annona muricata
is well established, its effect on MMP-2 and MMP-9, a major target in several types of cancers, has not been studied. Powdered samples of various parts of
A. muricata
like fruit, stem, seed, and twig extracted using aqueous methanol showed significant dose-dependent inhibition of MMP-2 and MMP-9 in a highly metastatic fibrosarcoma cell line, HT1080. Additionally, these extracts also up-regulated the expression of several endogenous inhibitors of MMP-2 and MMP-9 like REversion-inducing Cysteine-rich protein with Kazal motifs (RECK) and Tissue Inhibitor of Metalloproteinase-2 (TIMP-2). Furthermore, primary cells developed from tumor tissues obtained from patients not exposed to chemotherapy, also exhibited similar results. Remarkably, the inhibition of MMP-2 and MMP-9 observed was tumor specific, with the
A. muricata
fruit extract showing only 2% inhibition in cells obtained from normal tissues, when compared to 60% inhibition observed in cells obtained from tumor samples. The present study elucidates a novel mechanism by which
A. muricata
extracts selectively exhibit their anti-cancer activity in tumor cells by down-regulating MMP-2 and MMP-9 that are important biomarkers in cancer.</abstract><cop>New Delhi</cop><pub>Springer India</pub><doi>10.1007/s12038-020-00056-z</doi></addata></record> |
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| ispartof | Journal of biosciences, 2020-12, Vol.45 (1), Article 89 |
| issn | 0250-5991 0973-7138 |
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| source | Indian Academy of Sciences; Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Annona muricata Anticancer properties Apoptosis Biomarkers Biomedical and Life Sciences Biomedicine Cancer Cell Biology Cell migration Chemotherapy Extracellular Extracellular matrix Fibrosarcoma Fruits Gelatinase A Gelatinase B Life Sciences Matrix metalloproteinases Metalloproteinase Metastases Microbiology Neoplasms Plant Sciences Reversion Tissue Tissue inhibitor of metalloproteinase 2 Tumor cells Tumors Zoology |
| title | RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata |
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