Niacinamide mitigates SASP‐related inflammation induced by environmental stressors in human epidermal keratinocytes and skin

Objective To evaluate whether niacinamide (Nam) can mitigate production of inflammatory and senescence‐related biomarkers induced by environmental stressors. Methods Human epidermal keratinocytes were exposed to UVB, urban dust, diesel exhaust and cigarette smoke extract and treated with Nam or vehi...

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Veröffentlicht in:	International journal of cosmetic science 2020-10, Vol.42 (5), p.501-511
Hauptverfasser:	Bierman, John C., Laughlin, Timothy, Tamura, Makio, Hulette, Ben C., Mack, Catherine E., Sherrill, Joseph D., Tan, Christina Y.R., Morenc, Malgorzata, Bellanger, Sophie, Oblong, John E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Biomarkers Biomarkers - metabolism cell culture Cellular Senescence - drug effects Cigarette smoke Cigarettes claim substantiation Computer simulation Diesel Diesel engines Double-Blind Method Dust Environmental stress environmental stressors Epidermis - drug effects Erythema Exposure Female Humans Inflammation Inflammation - chemically induced Inflammation - prevention & control Inflammatory response Keratinocytes Keratinocytes - drug effects niacinamide Niacinamide - pharmacology Nicotinamide Particulate matter Phenotypes Pretreatment Prostaglandin E2 Quantitation Radiation dosage Senescence Skin Skin - drug effects skin physiology/structure Smoke Synthesis Three dimensional models Ultraviolet radiation
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