A prospective observational study of developmental outcomes in survivors of neonatal hypoxic ischaemic encephalopathy in South Africa
Background. Neonatal hypoxic ischaemic encephalopathy (NHIE) is an important cause of long-term handicap in survivors. There is limited information on the burden of handicap from NHIE in sub-Saharan Africa.Objectives. To determine the developmental outcomes in survivors of NHIE in South Africa (SA)....
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| Veröffentlicht in: | South African medical journal 2020-04, Vol.110 (4), p.308-312 |
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| container_title | South African medical journal |
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| creator | Ramdin, T.D. Ballot, D.E. Cooper, P.A. Chirwa, T. Pepper, M.S. Rakotsoane, D. |
| description | Background. Neonatal hypoxic ischaemic encephalopathy (NHIE) is an important cause of long-term handicap in survivors. There is limited information on the burden of handicap from NHIE in sub-Saharan Africa.Objectives. To determine the developmental outcomes in survivors of NHIE in South Africa (SA).Methods. In this prospective observational study, the developmental outcomes in 84 infants who had survived hypoxic ischaemic encephalopathy (the NHIE group) were compared with those in 64 unaffected infants (the control group). The Bayley Scales of Infant Development version III were used for assessment of developmental outcomes.Results. Significant differences were found between the developmental outcomes of the two groups, with a significantly lower composite language score and higher proportions with language, motor and cognitive developmental delays in the NHIE group than in the control group. Cerebral palsy (CP) was present in 13 of the infants with NHIE (15.5%) and none in the control group (pConclusions. Survivors of NHIE in SA are at risk of poor developmental outcomes. |
| doi_str_mv | 10.7196/SAMJ.2020.v110i4.14311 |
| format | Article |
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Neonatal hypoxic ischaemic encephalopathy (NHIE) is an important cause of long-term handicap in survivors. There is limited information on the burden of handicap from NHIE in sub-Saharan Africa.Objectives. To determine the developmental outcomes in survivors of NHIE in South Africa (SA).Methods. In this prospective observational study, the developmental outcomes in 84 infants who had survived hypoxic ischaemic encephalopathy (the NHIE group) were compared with those in 64 unaffected infants (the control group). The Bayley Scales of Infant Development version III were used for assessment of developmental outcomes.Results. Significant differences were found between the developmental outcomes of the two groups, with a significantly lower composite language score and higher proportions with language, motor and cognitive developmental delays in the NHIE group than in the control group. Cerebral palsy (CP) was present in 13 of the infants with NHIE (15.5%) and none in the control group (pConclusions. Survivors of NHIE in SA are at risk of poor developmental outcomes.</description><identifier>ISSN: 0256-9574</identifier><identifier>EISSN: 2078-5135</identifier><identifier>DOI: 10.7196/SAMJ.2020.v110i4.14311</identifier><language>eng</language><publisher>Health and Medical Publishing Group (HMPG)</publisher><ispartof>South African medical journal, 2020-04, Vol.110 (4), p.308-312</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-33bb0d9faef02e81e7e2fedd51cae1feaeb1f7806affe04a02973a6e758d3b643</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925,39242</link.rule.ids></links><search><creatorcontrib>Ramdin, T.D.</creatorcontrib><creatorcontrib>Ballot, D.E.</creatorcontrib><creatorcontrib>Cooper, P.A.</creatorcontrib><creatorcontrib>Chirwa, T.</creatorcontrib><creatorcontrib>Pepper, M.S.</creatorcontrib><creatorcontrib>Rakotsoane, D.</creatorcontrib><title>A prospective observational study of developmental outcomes in survivors of neonatal hypoxic ischaemic encephalopathy in South Africa</title><title>South African medical journal</title><description>Background. Neonatal hypoxic ischaemic encephalopathy (NHIE) is an important cause of long-term handicap in survivors. There is limited information on the burden of handicap from NHIE in sub-Saharan Africa.Objectives. To determine the developmental outcomes in survivors of NHIE in South Africa (SA).Methods. In this prospective observational study, the developmental outcomes in 84 infants who had survived hypoxic ischaemic encephalopathy (the NHIE group) were compared with those in 64 unaffected infants (the control group). The Bayley Scales of Infant Development version III were used for assessment of developmental outcomes.Results. Significant differences were found between the developmental outcomes of the two groups, with a significantly lower composite language score and higher proportions with language, motor and cognitive developmental delays in the NHIE group than in the control group. Cerebral palsy (CP) was present in 13 of the infants with NHIE (15.5%) and none in the control group (pConclusions. Survivors of NHIE in SA are at risk of poor developmental outcomes.</description><issn>0256-9574</issn><issn>2078-5135</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>JRA</sourceid><recordid>eNotkMuO1DAQRaMRSNMM_ALykk16_E6yQq3W8BgNYjGwtipOWTFK4hA7Ef0B_DfONKtyle-9qjpF8Z7RY8Uaff98-vZ45JTT48YY9fLIpGDspjhwWtWlYkK9Kg6UK102qpK3xZsYf9Hcq0Yfir8nMi8hzmiT35CENuKyQfJhgoHEtHYXEhzpcMMhzCNOKY_DmmwYMRI_kbgum9_CEnfZhNm2K_rLHP54S3y0PeCYXzhZnHvIIZD6y-58zjE9ObnFW3hbvHYwRHz3v94VPz89_Dh_KZ--f_56Pj2VVkiZSiHalnaNA3SUY82wQu6w6xSzgMwhYMtcVVMNziGVQHlTCdBYqboTrZbirvhwzc03_14xJjPmFXEYIK--RsMlF0poXdVZqq9Sm_HEBZ2ZFz_CcjGMmp272bmbnbu5cjcv3LPx49UYofUTJhMB57U1fUpzNH03mB6mbkCz_zGqsv_h8WzyCRyodJ0V_wD4npMY</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Ramdin, T.D.</creator><creator>Ballot, D.E.</creator><creator>Cooper, P.A.</creator><creator>Chirwa, T.</creator><creator>Pepper, M.S.</creator><creator>Rakotsoane, D.</creator><general>Health and Medical Publishing Group (HMPG)</general><scope>AEIZH</scope><scope>JRA</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200401</creationdate><title>A prospective observational study of developmental outcomes in survivors of neonatal hypoxic ischaemic encephalopathy in South Africa</title><author>Ramdin, T.D. ; Ballot, D.E. ; Cooper, P.A. ; Chirwa, T. ; Pepper, M.S. ; Rakotsoane, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-33bb0d9faef02e81e7e2fedd51cae1feaeb1f7806affe04a02973a6e758d3b643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramdin, T.D.</creatorcontrib><creatorcontrib>Ballot, D.E.</creatorcontrib><creatorcontrib>Cooper, P.A.</creatorcontrib><creatorcontrib>Chirwa, T.</creatorcontrib><creatorcontrib>Pepper, M.S.</creatorcontrib><creatorcontrib>Rakotsoane, D.</creatorcontrib><collection>Sabinet:Open Access</collection><collection>Sabinet African Journals Open Access Collection</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>South African medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramdin, T.D.</au><au>Ballot, D.E.</au><au>Cooper, P.A.</au><au>Chirwa, T.</au><au>Pepper, M.S.</au><au>Rakotsoane, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prospective observational study of developmental outcomes in survivors of neonatal hypoxic ischaemic encephalopathy in South Africa</atitle><jtitle>South African medical journal</jtitle><date>2020-04-01</date><risdate>2020</risdate><volume>110</volume><issue>4</issue><spage>308</spage><epage>312</epage><pages>308-312</pages><issn>0256-9574</issn><eissn>2078-5135</eissn><abstract>Background. Neonatal hypoxic ischaemic encephalopathy (NHIE) is an important cause of long-term handicap in survivors. There is limited information on the burden of handicap from NHIE in sub-Saharan Africa.Objectives. To determine the developmental outcomes in survivors of NHIE in South Africa (SA).Methods. In this prospective observational study, the developmental outcomes in 84 infants who had survived hypoxic ischaemic encephalopathy (the NHIE group) were compared with those in 64 unaffected infants (the control group). The Bayley Scales of Infant Development version III were used for assessment of developmental outcomes.Results. Significant differences were found between the developmental outcomes of the two groups, with a significantly lower composite language score and higher proportions with language, motor and cognitive developmental delays in the NHIE group than in the control group. Cerebral palsy (CP) was present in 13 of the infants with NHIE (15.5%) and none in the control group (pConclusions. Survivors of NHIE in SA are at risk of poor developmental outcomes.</abstract><pub>Health and Medical Publishing Group (HMPG)</pub><doi>10.7196/SAMJ.2020.v110i4.14311</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| title | A prospective observational study of developmental outcomes in survivors of neonatal hypoxic ischaemic encephalopathy in South Africa |
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