Structural Basis of Noscapine Activation for Tubulin Binding

Noscapine is a natural alkaloid that is used as an antitussive medicine. However, it also acts as a weak anticancer agent in certain in vivo models through a mechanism that is largely unknown. Here, we performed structural studies and show that the cytotoxic agent 7A-O-demethoxy-amino-noscapine (7A-...

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Veröffentlicht in:	Journal of medicinal chemistry 2020-08, Vol.63 (15), p.8495-8501
Hauptverfasser:	Oliva, María A, Prota, Andrea E, Rodríguez-Salarichs, Javier, Bennani, Youssef L, Jiménez-Barbero, Jesús, Bargsten, Katja, Canales, Ángeles, Steinmetz, Michel O, Díaz, J. Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Binding Sites - drug effects Colchicine - metabolism Crystallography, X-Ray Drug Design Humans Molecular Docking Simulation Noscapine - analogs & derivatives Noscapine - chemistry Noscapine - pharmacology Protein Binding - drug effects Tubulin - chemistry Tubulin - metabolism Tubulin Modulators - chemistry Tubulin Modulators - pharmacology
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