Prognostic value of tumor-infiltrating lymphocytes (TILs) and their association with PD-L1 expression and DNA repair protein RAD51 in patients with resected non-small cell lung carcinoma

•RAD51 nuclear loss is weakly associated with high TILs in curatively resected NSCLC•RAD51 nuclear loss is weakly associated with high PD-L1 expression in resected NSCLC•Both associations were more pronounced after exposure to chemo- or radiotherapy•TILs and RAD51 nuclear loss both have prognostic v...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2020-09, Vol.147, p.30-38
Hauptverfasser:	Gachechiladze, Mariam, Škarda, Josef, Skanderová, Daniela, Überall, Ivo, Kolek, Vítězslav, Smičkova, Petra, Vojta, Petr, Vbrková, Jana, Hajdúch, Marián, Shani, Ilay, Kolář, Zdeněk, Stahel, Rolf, Weder, Walter, Rulle, Undine, Soltermann, Alex, Joerger, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	B7-H1 Antigen - genetics Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - therapy DNA Repair Humans Lung Neoplasms - genetics Lung Neoplasms - therapy Lymphocytes, Tumor-Infiltrating Neoadjuvant PD-L1 Prognosis Prognostic RAD51 Rad51 Recombinase - genetics Switzerland Tumor infiltrating lymphocytes
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