Cyclotide Structures Revealed by NMR, with a Little Help from X‐ray Crystallography

This review highlights the predominant role that NMR has had in determining the structures of cyclotides, a fascinating class of macrocyclic peptides found in plants. Cyclotides contain a cystine knot, a compact structural motif that is constrained by three disulfide bonds and able to resist chemica...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2020-12, Vol.21 (24), p.3463-3475
Hauptverfasser:	Handley, Thomas N. G., Wang, Conan K., Harvey, Peta J., Lawrence, Nicole, Craik, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biodegradation cis-proline Crystallography cyclotides Cystine cystine knot Degradation Disulfide bonds disulfide connectivity NMR NMR spectroscopy Nuclear magnetic resonance Peptides Proteolysis racemic crystallography
Online-Zugang:	Volltext
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