Esophageal atresia in twins compared to singletons: In utero manifestation and characteristics
Objective Esophageal atresia with/without tracheo‐esophageal fistula (EA/TEF) is more common among twins. The detection of polyhydramnios might be altered in twins, leading to EA/TEF underdiagnosis, prenatally. The aim of the study was to compare the prenatal manifestation of EA/TEF between twins an...
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| Veröffentlicht in: | Prenatal diagnosis 2020-10, Vol.40 (11), p.1418-1425 |
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| container_title | Prenatal diagnosis |
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| creator | Weissbach, Tal Kassif, Eran Kushnir, Anya Shust‐Barequet, Shir Leibovitch, Leah Eliasi, Elior Elkan‐Miller, Tal Zajicek, Michal Yinon, Yoav Weisz, Boaz |
| description | Objective
Esophageal atresia with/without tracheo‐esophageal fistula (EA/TEF) is more common among twins. The detection of polyhydramnios might be altered in twins, leading to EA/TEF underdiagnosis, prenatally. The aim of the study was to compare the prenatal manifestation of EA/TEF between twins and singletons.
Methods
A 12‐year study of EA/TEF cases was performed at a tertiary center. Cases exhibiting (a) small/absent stomach or (b) polyhydramnios were considered “suspected”; cases with (c) esophageal pouch were considered “detected.” We compared the rate and timing of appearance of these signs between the groups.
Results
There were 76 cases of EA/TEF, of which 17 were a co‐twin. All twin pairs were EA/TEF discordant. The prevalence of EA/TEF at our center was 1:750 for twins (1:319 monochorionic and 1:1133 dichorionic) and 1:2399 for singletons. The rate of small/absent stomach, polyhydramnios and pouch in twins vs singletons was 23.5%, 47.1%, 29.4% and 39.7%, 72.4%,34.5%, respectively (P = .2, P = .09 and P = .7). Esophageal pouch was detected earlier in twins (P = .03). Twins were scanned more frequently (×1.8 times, P = .01).
Conclusion
EA/TEF is more prevalent in twins. Despite lower rate of polyhydramnios, twins were similarly detected prenatally as singletons, and this was accomplished earlier in pregnancy; perhaps reflecting more frequent scans. |
| doi_str_mv | 10.1002/pd.5785 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2423069720</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2423069720</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4115-c10384830fa40318aec9d7d1ae09523ce6e8d9cc1f8a7383d394b52a8bc392a23</originalsourceid><addsrcrecordid>eNp10E1LAzEQBuAgitYq_gMJeFCQaj52u1lvUusHCHrQq8s0ydaU3WRNskj_vamtHgRPMzAPL8OL0BElF5QQdtmpi7wQ-RYaUFIWI8IY30YDQtPORU730H4IiwQFK4tdtMfZOGfjjA7Q2zS47h3mGhoM0etgABuL46exAUvXduC1wtHhYOy80dHZcIUfLO6j9g63YE2tQ4RonMVgFZbv4EGmownRyHCAdmpogj7czCF6vZ2-TO5Hj093D5Prx5HMKM1HkhIuMsFJDRnhVICWpSoUBU3KnHGpx1qoUkpaCyi44IqX2SxnIGaSlwwYH6KzdW7n3UefPqpaE6RuGrDa9aFiGeNkXBaMJHryhy5c7236Lqk8FVeklpI6XSvpXQhe11XnTQt-WVFSrSqvOlWtKk_yeJPXz1qtft1Pxwmcr8GnafTyv5zq-eY77guuzYkK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2452237282</pqid></control><display><type>article</type><title>Esophageal atresia in twins compared to singletons: In utero manifestation and characteristics</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Weissbach, Tal ; Kassif, Eran ; Kushnir, Anya ; Shust‐Barequet, Shir ; Leibovitch, Leah ; Eliasi, Elior ; Elkan‐Miller, Tal ; Zajicek, Michal ; Yinon, Yoav ; Weisz, Boaz</creator><creatorcontrib>Weissbach, Tal ; Kassif, Eran ; Kushnir, Anya ; Shust‐Barequet, Shir ; Leibovitch, Leah ; Eliasi, Elior ; Elkan‐Miller, Tal ; Zajicek, Michal ; Yinon, Yoav ; Weisz, Boaz</creatorcontrib><description>Objective
Esophageal atresia with/without tracheo‐esophageal fistula (EA/TEF) is more common among twins. The detection of polyhydramnios might be altered in twins, leading to EA/TEF underdiagnosis, prenatally. The aim of the study was to compare the prenatal manifestation of EA/TEF between twins and singletons.
Methods
A 12‐year study of EA/TEF cases was performed at a tertiary center. Cases exhibiting (a) small/absent stomach or (b) polyhydramnios were considered “suspected”; cases with (c) esophageal pouch were considered “detected.” We compared the rate and timing of appearance of these signs between the groups.
Results
There were 76 cases of EA/TEF, of which 17 were a co‐twin. All twin pairs were EA/TEF discordant. The prevalence of EA/TEF at our center was 1:750 for twins (1:319 monochorionic and 1:1133 dichorionic) and 1:2399 for singletons. The rate of small/absent stomach, polyhydramnios and pouch in twins vs singletons was 23.5%, 47.1%, 29.4% and 39.7%, 72.4%,34.5%, respectively (P = .2, P = .09 and P = .7). Esophageal pouch was detected earlier in twins (P = .03). Twins were scanned more frequently (×1.8 times, P = .01).
Conclusion
EA/TEF is more prevalent in twins. Despite lower rate of polyhydramnios, twins were similarly detected prenatally as singletons, and this was accomplished earlier in pregnancy; perhaps reflecting more frequent scans.</description><identifier>ISSN: 0197-3851</identifier><identifier>EISSN: 1097-0223</identifier><identifier>DOI: 10.1002/pd.5785</identifier><identifier>PMID: 32652641</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Esophagus ; Pregnancy ; Stomach ; Twins</subject><ispartof>Prenatal diagnosis, 2020-10, Vol.40 (11), p.1418-1425</ispartof><rights>2020 John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons Ltd.</rights><rights>2020 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4115-c10384830fa40318aec9d7d1ae09523ce6e8d9cc1f8a7383d394b52a8bc392a23</citedby><cites>FETCH-LOGICAL-c4115-c10384830fa40318aec9d7d1ae09523ce6e8d9cc1f8a7383d394b52a8bc392a23</cites><orcidid>0000-0003-1606-452X ; 0000-0002-2201-9461 ; 0000-0002-0599-5006 ; 0000-0001-7430-2237 ; 0000-0001-5558-7871 ; 0000-0003-0702-370X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpd.5785$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpd.5785$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32652641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weissbach, Tal</creatorcontrib><creatorcontrib>Kassif, Eran</creatorcontrib><creatorcontrib>Kushnir, Anya</creatorcontrib><creatorcontrib>Shust‐Barequet, Shir</creatorcontrib><creatorcontrib>Leibovitch, Leah</creatorcontrib><creatorcontrib>Eliasi, Elior</creatorcontrib><creatorcontrib>Elkan‐Miller, Tal</creatorcontrib><creatorcontrib>Zajicek, Michal</creatorcontrib><creatorcontrib>Yinon, Yoav</creatorcontrib><creatorcontrib>Weisz, Boaz</creatorcontrib><title>Esophageal atresia in twins compared to singletons: In utero manifestation and characteristics</title><title>Prenatal diagnosis</title><addtitle>Prenat Diagn</addtitle><description>Objective
Esophageal atresia with/without tracheo‐esophageal fistula (EA/TEF) is more common among twins. The detection of polyhydramnios might be altered in twins, leading to EA/TEF underdiagnosis, prenatally. The aim of the study was to compare the prenatal manifestation of EA/TEF between twins and singletons.
Methods
A 12‐year study of EA/TEF cases was performed at a tertiary center. Cases exhibiting (a) small/absent stomach or (b) polyhydramnios were considered “suspected”; cases with (c) esophageal pouch were considered “detected.” We compared the rate and timing of appearance of these signs between the groups.
Results
There were 76 cases of EA/TEF, of which 17 were a co‐twin. All twin pairs were EA/TEF discordant. The prevalence of EA/TEF at our center was 1:750 for twins (1:319 monochorionic and 1:1133 dichorionic) and 1:2399 for singletons. The rate of small/absent stomach, polyhydramnios and pouch in twins vs singletons was 23.5%, 47.1%, 29.4% and 39.7%, 72.4%,34.5%, respectively (P = .2, P = .09 and P = .7). Esophageal pouch was detected earlier in twins (P = .03). Twins were scanned more frequently (×1.8 times, P = .01).
Conclusion
EA/TEF is more prevalent in twins. Despite lower rate of polyhydramnios, twins were similarly detected prenatally as singletons, and this was accomplished earlier in pregnancy; perhaps reflecting more frequent scans.</description><subject>Esophagus</subject><subject>Pregnancy</subject><subject>Stomach</subject><subject>Twins</subject><issn>0197-3851</issn><issn>1097-0223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp10E1LAzEQBuAgitYq_gMJeFCQaj52u1lvUusHCHrQq8s0ydaU3WRNskj_vamtHgRPMzAPL8OL0BElF5QQdtmpi7wQ-RYaUFIWI8IY30YDQtPORU730H4IiwQFK4tdtMfZOGfjjA7Q2zS47h3mGhoM0etgABuL46exAUvXduC1wtHhYOy80dHZcIUfLO6j9g63YE2tQ4RonMVgFZbv4EGmownRyHCAdmpogj7czCF6vZ2-TO5Hj093D5Prx5HMKM1HkhIuMsFJDRnhVICWpSoUBU3KnHGpx1qoUkpaCyi44IqX2SxnIGaSlwwYH6KzdW7n3UefPqpaE6RuGrDa9aFiGeNkXBaMJHryhy5c7236Lqk8FVeklpI6XSvpXQhe11XnTQt-WVFSrSqvOlWtKk_yeJPXz1qtft1Pxwmcr8GnafTyv5zq-eY77guuzYkK</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Weissbach, Tal</creator><creator>Kassif, Eran</creator><creator>Kushnir, Anya</creator><creator>Shust‐Barequet, Shir</creator><creator>Leibovitch, Leah</creator><creator>Eliasi, Elior</creator><creator>Elkan‐Miller, Tal</creator><creator>Zajicek, Michal</creator><creator>Yinon, Yoav</creator><creator>Weisz, Boaz</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1606-452X</orcidid><orcidid>https://orcid.org/0000-0002-2201-9461</orcidid><orcidid>https://orcid.org/0000-0002-0599-5006</orcidid><orcidid>https://orcid.org/0000-0001-7430-2237</orcidid><orcidid>https://orcid.org/0000-0001-5558-7871</orcidid><orcidid>https://orcid.org/0000-0003-0702-370X</orcidid></search><sort><creationdate>202010</creationdate><title>Esophageal atresia in twins compared to singletons: In utero manifestation and characteristics</title><author>Weissbach, Tal ; Kassif, Eran ; Kushnir, Anya ; Shust‐Barequet, Shir ; Leibovitch, Leah ; Eliasi, Elior ; Elkan‐Miller, Tal ; Zajicek, Michal ; Yinon, Yoav ; Weisz, Boaz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4115-c10384830fa40318aec9d7d1ae09523ce6e8d9cc1f8a7383d394b52a8bc392a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Esophagus</topic><topic>Pregnancy</topic><topic>Stomach</topic><topic>Twins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weissbach, Tal</creatorcontrib><creatorcontrib>Kassif, Eran</creatorcontrib><creatorcontrib>Kushnir, Anya</creatorcontrib><creatorcontrib>Shust‐Barequet, Shir</creatorcontrib><creatorcontrib>Leibovitch, Leah</creatorcontrib><creatorcontrib>Eliasi, Elior</creatorcontrib><creatorcontrib>Elkan‐Miller, Tal</creatorcontrib><creatorcontrib>Zajicek, Michal</creatorcontrib><creatorcontrib>Yinon, Yoav</creatorcontrib><creatorcontrib>Weisz, Boaz</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Prenatal diagnosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weissbach, Tal</au><au>Kassif, Eran</au><au>Kushnir, Anya</au><au>Shust‐Barequet, Shir</au><au>Leibovitch, Leah</au><au>Eliasi, Elior</au><au>Elkan‐Miller, Tal</au><au>Zajicek, Michal</au><au>Yinon, Yoav</au><au>Weisz, Boaz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Esophageal atresia in twins compared to singletons: In utero manifestation and characteristics</atitle><jtitle>Prenatal diagnosis</jtitle><addtitle>Prenat Diagn</addtitle><date>2020-10</date><risdate>2020</risdate><volume>40</volume><issue>11</issue><spage>1418</spage><epage>1425</epage><pages>1418-1425</pages><issn>0197-3851</issn><eissn>1097-0223</eissn><abstract>Objective
Esophageal atresia with/without tracheo‐esophageal fistula (EA/TEF) is more common among twins. The detection of polyhydramnios might be altered in twins, leading to EA/TEF underdiagnosis, prenatally. The aim of the study was to compare the prenatal manifestation of EA/TEF between twins and singletons.
Methods
A 12‐year study of EA/TEF cases was performed at a tertiary center. Cases exhibiting (a) small/absent stomach or (b) polyhydramnios were considered “suspected”; cases with (c) esophageal pouch were considered “detected.” We compared the rate and timing of appearance of these signs between the groups.
Results
There were 76 cases of EA/TEF, of which 17 were a co‐twin. All twin pairs were EA/TEF discordant. The prevalence of EA/TEF at our center was 1:750 for twins (1:319 monochorionic and 1:1133 dichorionic) and 1:2399 for singletons. The rate of small/absent stomach, polyhydramnios and pouch in twins vs singletons was 23.5%, 47.1%, 29.4% and 39.7%, 72.4%,34.5%, respectively (P = .2, P = .09 and P = .7). Esophageal pouch was detected earlier in twins (P = .03). Twins were scanned more frequently (×1.8 times, P = .01).
Conclusion
EA/TEF is more prevalent in twins. Despite lower rate of polyhydramnios, twins were similarly detected prenatally as singletons, and this was accomplished earlier in pregnancy; perhaps reflecting more frequent scans.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>32652641</pmid><doi>10.1002/pd.5785</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1606-452X</orcidid><orcidid>https://orcid.org/0000-0002-2201-9461</orcidid><orcidid>https://orcid.org/0000-0002-0599-5006</orcidid><orcidid>https://orcid.org/0000-0001-7430-2237</orcidid><orcidid>https://orcid.org/0000-0001-5558-7871</orcidid><orcidid>https://orcid.org/0000-0003-0702-370X</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Esophagus Pregnancy Stomach Twins |
| title | Esophageal atresia in twins compared to singletons: In utero manifestation and characteristics |
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