Genetic variants in IL4RA, IL6, and IL12B genes and susceptibility to hepatitis B and C virus infections among Iraqi patients
Hepatitis B and C viruses (HBV and HCV) are common causative pathogens of viral hepatitis. Progression of both infections is determined by virus‐ and host‐related factors. Cytokines are important host genetic factors that may have a predisposing role in HBV and HCV infections. This case‐control stud...
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| Veröffentlicht in: | Journal of medical virology 2020-12, Vol.92 (12), p.3448-3458 |
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| creator | Al‐Saffar, Osama B. Ad'hiah, Ali H. |
| description | Hepatitis B and C viruses (HBV and HCV) are common causative pathogens of viral hepatitis. Progression of both infections is determined by virus‐ and host‐related factors. Cytokines are important host genetic factors that may have a predisposing role in HBV and HCV infections. This case‐control study evaluated the genetic association of IL4RA+1902 (rs1801275), IL6−174 (rs1800795), IL6−597 (rs1800797), and IL12B−1188 (rs3212227) variants with chronic HBV and HCV infections among Iraqi patients. A total of 220 viral hepatitis patients were enrolled in the study (113 HBV and 107 HCV), together with 141 healthy subjects. Sequence‐specific primer polymerase chain reaction assay was the genotyping method. Results revealed that under a dominant genetic model, IL6−174 variant was significantly associated with HBV infection, whereas no association with the HCV risk was reported. However, the risk for both infections was markedly associated with IL6−597 variant under recessive, dominant, and codominant genetic models. Estimation of IL6−174‐IL6−597 haplotypes depicted that G‐A haplotype was significantly associated with an increased risk to develop HBV infection, whereas a significantly decreased risk was associated with G‐G and C‐G haplotypes. For HCV, G‐G and C‐A haplotypes were significantly associated with risk of HCV infection. IL4RA+1902 and IL12B−1188 variants showed no association with HBV or HCV risk. Analysis of variance revealed no significant association between genotypes of the four determined single‐nucleotide polymorphisms and HBV or HCV viral load. In conclusion, the study supports the concept that IL6−597 variant is associated with susceptibility to HBV and HCV infections among Iraqis. The risk of HBV infection is further associated with IL6−174 variant.
Highlights
IL6‐597 variant is associated with susceptibility to HBV and HCV infections.
IL6‐174 variant is a further risk factor for HBV infection.
IL4RA+1902 and IL12B‐1188 variants are not associated with HBV− or HCV‐risk. |
| doi_str_mv | 10.1002/jmv.26297 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2423069651</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2423069651</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2687-dfc6e85fc3f2b5d47f941d6bee23957905d7b1f94a7d53cce8969811066776ad3</originalsourceid><addsrcrecordid>eNp10clKAzEABuAgitbl4AtIwIuCo0kmy-SoxaVSEUS9DplMRlNmaZNMpQff3bRVD4KnLHz5k_ADcIjROUaIXEya-TnhRIoNMMBI8kQigTfBAGHKE84x2wG73k8QQpkkZBvspIQzwiQdgM9b05pgNZwrZ1UbPLQtHI3p0-VZHPgZVG0ZJ5hcwbco_Wrte6_NNNjC1jYsYOjgu5mqYIP18GolhnBuXb8Mq4wOtmvjwaZr3-DIqZmFS2ziZftgq1K1Nwff4x54ubl-Ht4l48fb0fBynGjCM5GUleYmY5VOK1KwkopKUlzywhiSSiYkYqUocNxUomSp1iaTXGYYI86F4KpM98DJOnfqullvfMgbG79Q16o1Xe9zQkmKuOQMR3r8h0663rXxdVExIShFGY3qdK2067x3psqnzjbKLXKM8mUneewkX3US7dF3Yl80pvyVPyVEcLEGH7Y2i_-T8vuH13XkFwKblBY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2457744084</pqid></control><display><type>article</type><title>Genetic variants in IL4RA, IL6, and IL12B genes and susceptibility to hepatitis B and C virus infections among Iraqi patients</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Al‐Saffar, Osama B. ; Ad'hiah, Ali H.</creator><creatorcontrib>Al‐Saffar, Osama B. ; Ad'hiah, Ali H.</creatorcontrib><description>Hepatitis B and C viruses (HBV and HCV) are common causative pathogens of viral hepatitis. Progression of both infections is determined by virus‐ and host‐related factors. Cytokines are important host genetic factors that may have a predisposing role in HBV and HCV infections. This case‐control study evaluated the genetic association of IL4RA+1902 (rs1801275), IL6−174 (rs1800795), IL6−597 (rs1800797), and IL12B−1188 (rs3212227) variants with chronic HBV and HCV infections among Iraqi patients. A total of 220 viral hepatitis patients were enrolled in the study (113 HBV and 107 HCV), together with 141 healthy subjects. Sequence‐specific primer polymerase chain reaction assay was the genotyping method. Results revealed that under a dominant genetic model, IL6−174 variant was significantly associated with HBV infection, whereas no association with the HCV risk was reported. However, the risk for both infections was markedly associated with IL6−597 variant under recessive, dominant, and codominant genetic models. Estimation of IL6−174‐IL6−597 haplotypes depicted that G‐A haplotype was significantly associated with an increased risk to develop HBV infection, whereas a significantly decreased risk was associated with G‐G and C‐G haplotypes. For HCV, G‐G and C‐A haplotypes were significantly associated with risk of HCV infection. IL4RA+1902 and IL12B−1188 variants showed no association with HBV or HCV risk. Analysis of variance revealed no significant association between genotypes of the four determined single‐nucleotide polymorphisms and HBV or HCV viral load. In conclusion, the study supports the concept that IL6−597 variant is associated with susceptibility to HBV and HCV infections among Iraqis. The risk of HBV infection is further associated with IL6−174 variant.
Highlights
IL6‐597 variant is associated with susceptibility to HBV and HCV infections.
IL6‐174 variant is a further risk factor for HBV infection.
IL4RA+1902 and IL12B‐1188 variants are not associated with HBV− or HCV‐risk.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.26297</identifier><identifier>PMID: 32652594</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Case-Control Studies ; cytokine ; Cytokines ; Female ; Genetic diversity ; Genetic factors ; Genetic Predisposition to Disease ; Genetic variance ; Genotype ; Genotypes ; Genotyping ; haplotype ; Haplotypes ; Health risks ; Hepatitis ; Hepatitis B ; Hepatitis B - genetics ; Hepatitis B - virology ; hepatitis B virus ; Hepatitis B, Chronic - genetics ; Hepatitis B, Chronic - virology ; hepatitis C virus ; Hepatitis C, Chronic - genetics ; Hepatitis C, Chronic - virology ; Humans ; Infections ; Interleukin 1 ; Interleukin 6 ; Interleukin-12 Subunit p40 - genetics ; Interleukin-4 Receptor alpha Subunit - genetics ; Interleukin-6 - genetics ; Iraq ; Iraq - epidemiology ; Male ; Middle Aged ; Nucleotides ; Polymerase chain reaction ; polymorphism ; Polymorphism, Single Nucleotide ; Risk analysis ; Risk factors ; Variance analysis ; Virology ; Viruses ; Young Adult</subject><ispartof>Journal of medical virology, 2020-12, Vol.92 (12), p.3448-3458</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2687-dfc6e85fc3f2b5d47f941d6bee23957905d7b1f94a7d53cce8969811066776ad3</citedby><cites>FETCH-LOGICAL-c2687-dfc6e85fc3f2b5d47f941d6bee23957905d7b1f94a7d53cce8969811066776ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.26297$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.26297$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32652594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al‐Saffar, Osama B.</creatorcontrib><creatorcontrib>Ad'hiah, Ali H.</creatorcontrib><title>Genetic variants in IL4RA, IL6, and IL12B genes and susceptibility to hepatitis B and C virus infections among Iraqi patients</title><title>Journal of medical virology</title><addtitle>J Med Virol</addtitle><description>Hepatitis B and C viruses (HBV and HCV) are common causative pathogens of viral hepatitis. Progression of both infections is determined by virus‐ and host‐related factors. Cytokines are important host genetic factors that may have a predisposing role in HBV and HCV infections. This case‐control study evaluated the genetic association of IL4RA+1902 (rs1801275), IL6−174 (rs1800795), IL6−597 (rs1800797), and IL12B−1188 (rs3212227) variants with chronic HBV and HCV infections among Iraqi patients. A total of 220 viral hepatitis patients were enrolled in the study (113 HBV and 107 HCV), together with 141 healthy subjects. Sequence‐specific primer polymerase chain reaction assay was the genotyping method. Results revealed that under a dominant genetic model, IL6−174 variant was significantly associated with HBV infection, whereas no association with the HCV risk was reported. However, the risk for both infections was markedly associated with IL6−597 variant under recessive, dominant, and codominant genetic models. Estimation of IL6−174‐IL6−597 haplotypes depicted that G‐A haplotype was significantly associated with an increased risk to develop HBV infection, whereas a significantly decreased risk was associated with G‐G and C‐G haplotypes. For HCV, G‐G and C‐A haplotypes were significantly associated with risk of HCV infection. IL4RA+1902 and IL12B−1188 variants showed no association with HBV or HCV risk. Analysis of variance revealed no significant association between genotypes of the four determined single‐nucleotide polymorphisms and HBV or HCV viral load. In conclusion, the study supports the concept that IL6−597 variant is associated with susceptibility to HBV and HCV infections among Iraqis. The risk of HBV infection is further associated with IL6−174 variant.
Highlights
IL6‐597 variant is associated with susceptibility to HBV and HCV infections.
IL6‐174 variant is a further risk factor for HBV infection.
IL4RA+1902 and IL12B‐1188 variants are not associated with HBV− or HCV‐risk.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>cytokine</subject><subject>Cytokines</subject><subject>Female</subject><subject>Genetic diversity</subject><subject>Genetic factors</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic variance</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Genotyping</subject><subject>haplotype</subject><subject>Haplotypes</subject><subject>Health risks</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B - genetics</subject><subject>Hepatitis B - virology</subject><subject>hepatitis B virus</subject><subject>Hepatitis B, Chronic - genetics</subject><subject>Hepatitis B, Chronic - virology</subject><subject>hepatitis C virus</subject><subject>Hepatitis C, Chronic - genetics</subject><subject>Hepatitis C, Chronic - virology</subject><subject>Humans</subject><subject>Infections</subject><subject>Interleukin 1</subject><subject>Interleukin 6</subject><subject>Interleukin-12 Subunit p40 - genetics</subject><subject>Interleukin-4 Receptor alpha Subunit - genetics</subject><subject>Interleukin-6 - genetics</subject><subject>Iraq</subject><subject>Iraq - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nucleotides</subject><subject>Polymerase chain reaction</subject><subject>polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Variance analysis</subject><subject>Virology</subject><subject>Viruses</subject><subject>Young Adult</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10clKAzEABuAgitbl4AtIwIuCo0kmy-SoxaVSEUS9DplMRlNmaZNMpQff3bRVD4KnLHz5k_ADcIjROUaIXEya-TnhRIoNMMBI8kQigTfBAGHKE84x2wG73k8QQpkkZBvspIQzwiQdgM9b05pgNZwrZ1UbPLQtHI3p0-VZHPgZVG0ZJ5hcwbco_Wrte6_NNNjC1jYsYOjgu5mqYIP18GolhnBuXb8Mq4wOtmvjwaZr3-DIqZmFS2ziZftgq1K1Nwff4x54ubl-Ht4l48fb0fBynGjCM5GUleYmY5VOK1KwkopKUlzywhiSSiYkYqUocNxUomSp1iaTXGYYI86F4KpM98DJOnfqullvfMgbG79Q16o1Xe9zQkmKuOQMR3r8h0663rXxdVExIShFGY3qdK2067x3psqnzjbKLXKM8mUneewkX3US7dF3Yl80pvyVPyVEcLEGH7Y2i_-T8vuH13XkFwKblBY</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Al‐Saffar, Osama B.</creator><creator>Ad'hiah, Ali H.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>202012</creationdate><title>Genetic variants in IL4RA, IL6, and IL12B genes and susceptibility to hepatitis B and C virus infections among Iraqi patients</title><author>Al‐Saffar, Osama B. ; Ad'hiah, Ali H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2687-dfc6e85fc3f2b5d47f941d6bee23957905d7b1f94a7d53cce8969811066776ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>cytokine</topic><topic>Cytokines</topic><topic>Female</topic><topic>Genetic diversity</topic><topic>Genetic factors</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic variance</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Genotyping</topic><topic>haplotype</topic><topic>Haplotypes</topic><topic>Health risks</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B - genetics</topic><topic>Hepatitis B - virology</topic><topic>hepatitis B virus</topic><topic>Hepatitis B, Chronic - genetics</topic><topic>Hepatitis B, Chronic - virology</topic><topic>hepatitis C virus</topic><topic>Hepatitis C, Chronic - genetics</topic><topic>Hepatitis C, Chronic - virology</topic><topic>Humans</topic><topic>Infections</topic><topic>Interleukin 1</topic><topic>Interleukin 6</topic><topic>Interleukin-12 Subunit p40 - genetics</topic><topic>Interleukin-4 Receptor alpha Subunit - genetics</topic><topic>Interleukin-6 - genetics</topic><topic>Iraq</topic><topic>Iraq - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nucleotides</topic><topic>Polymerase chain reaction</topic><topic>polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Variance analysis</topic><topic>Virology</topic><topic>Viruses</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al‐Saffar, Osama B.</creatorcontrib><creatorcontrib>Ad'hiah, Ali H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al‐Saffar, Osama B.</au><au>Ad'hiah, Ali H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic variants in IL4RA, IL6, and IL12B genes and susceptibility to hepatitis B and C virus infections among Iraqi patients</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J Med Virol</addtitle><date>2020-12</date><risdate>2020</risdate><volume>92</volume><issue>12</issue><spage>3448</spage><epage>3458</epage><pages>3448-3458</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>Hepatitis B and C viruses (HBV and HCV) are common causative pathogens of viral hepatitis. Progression of both infections is determined by virus‐ and host‐related factors. Cytokines are important host genetic factors that may have a predisposing role in HBV and HCV infections. This case‐control study evaluated the genetic association of IL4RA+1902 (rs1801275), IL6−174 (rs1800795), IL6−597 (rs1800797), and IL12B−1188 (rs3212227) variants with chronic HBV and HCV infections among Iraqi patients. A total of 220 viral hepatitis patients were enrolled in the study (113 HBV and 107 HCV), together with 141 healthy subjects. Sequence‐specific primer polymerase chain reaction assay was the genotyping method. Results revealed that under a dominant genetic model, IL6−174 variant was significantly associated with HBV infection, whereas no association with the HCV risk was reported. However, the risk for both infections was markedly associated with IL6−597 variant under recessive, dominant, and codominant genetic models. Estimation of IL6−174‐IL6−597 haplotypes depicted that G‐A haplotype was significantly associated with an increased risk to develop HBV infection, whereas a significantly decreased risk was associated with G‐G and C‐G haplotypes. For HCV, G‐G and C‐A haplotypes were significantly associated with risk of HCV infection. IL4RA+1902 and IL12B−1188 variants showed no association with HBV or HCV risk. Analysis of variance revealed no significant association between genotypes of the four determined single‐nucleotide polymorphisms and HBV or HCV viral load. In conclusion, the study supports the concept that IL6−597 variant is associated with susceptibility to HBV and HCV infections among Iraqis. The risk of HBV infection is further associated with IL6−174 variant.
Highlights
IL6‐597 variant is associated with susceptibility to HBV and HCV infections.
IL6‐174 variant is a further risk factor for HBV infection.
IL4RA+1902 and IL12B‐1188 variants are not associated with HBV− or HCV‐risk.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32652594</pmid><doi>10.1002/jmv.26297</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult Case-Control Studies cytokine Cytokines Female Genetic diversity Genetic factors Genetic Predisposition to Disease Genetic variance Genotype Genotypes Genotyping haplotype Haplotypes Health risks Hepatitis Hepatitis B Hepatitis B - genetics Hepatitis B - virology hepatitis B virus Hepatitis B, Chronic - genetics Hepatitis B, Chronic - virology hepatitis C virus Hepatitis C, Chronic - genetics Hepatitis C, Chronic - virology Humans Infections Interleukin 1 Interleukin 6 Interleukin-12 Subunit p40 - genetics Interleukin-4 Receptor alpha Subunit - genetics Interleukin-6 - genetics Iraq Iraq - epidemiology Male Middle Aged Nucleotides Polymerase chain reaction polymorphism Polymorphism, Single Nucleotide Risk analysis Risk factors Variance analysis Virology Viruses Young Adult |
| title | Genetic variants in IL4RA, IL6, and IL12B genes and susceptibility to hepatitis B and C virus infections among Iraqi patients |
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