Functional and behavioral signatures of Kv7 activator drug subtypes

Objective Voltage‐gated potassium channels of the KCNQ (Kv7) family are targeted by a variety of activator compounds with therapeutic potential for treatment of epilepsy. Exploration of this drug class has revealed a variety of effective compounds with diverse mechanisms. In this study, we aimed to...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2020-08, Vol.61 (8), p.1678-1690
Hauptverfasser:	Kanyo, Richard, Wang, Caroline K., Locskai, Laszlo F., Li, Jingru, Allison, W. Ted, Kurata, Harley T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anilides - pharmacology Animals Animals, Genetically Modified Anticonvulsants Anticonvulsants - classification Anticonvulsants - pharmacology Antiepileptic agents Behavior Bridged Bicyclo Compounds - pharmacology Calcium - metabolism Calcium imaging CaMPARI Carbamates - pharmacology Channel gating Convulsions & seizures Danio rerio Disease Models, Animal Drug Resistance - genetics Drug screening Drugs Epilepsy Epilepsy - drug therapy Epilepsy - metabolism Excitability In Vitro Techniques Ion channels KCNQ Potassium Channels - drug effects KCNQ Potassium Channels - genetics KCNQ Potassium Channels - metabolism KCNQ2 Potassium Channel - drug effects KCNQ2 Potassium Channel - genetics KCNQ2 Potassium Channel - metabolism KCNQ3 Potassium Channel - drug effects KCNQ3 Potassium Channel - genetics KCNQ3 Potassium Channel - metabolism Kv7 channel activator Larvae Luminescent Proteins - genetics Membrane Potentials Mutation Neurons - drug effects Neurons - metabolism Optical Imaging Patch-Clamp Techniques Phenylenediamines - pharmacology potassium channel Potassium channels Potassium channels (voltage-gated) retigabine Seizures Seizures - drug therapy Seizures - metabolism Zebrafish
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