Kinetics of Platelet Adhesion to Protein-Coated Surface in Whole Blood Samples at High Flow Rates
We studied platelet adhesion to fibrinogen-coated surface in whole blood samples under conditions of high flow rates. The degree of platelet adhesion was evaluated by the intensity of laser light scattered from protein-coated optical surface with adhered platelets. The intensity of adhesion in whole...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2020-06, Vol.169 (2), p.229-232 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Avtaeva, Yu. N. Mel’nikov, I. S. Okhota, S. D. Zozulya, N. I. Gabbasov, Z. A. |
| description | We studied platelet adhesion to fibrinogen-coated surface in whole blood samples under conditions of high flow rates. The degree of platelet adhesion was evaluated by the intensity of laser light scattered from protein-coated optical surface with adhered platelets. The intensity of adhesion in whole blood samples at high flow rates was by 2.7 (2.4; 4.1) times higher than in platelet-rich plasma samples. Among the factors intensifying platelet adhesion in the whole blood at high flow rates, von Willebrand factor is of utmost importance. At low flow rates, platelet adhesion almost totally depends on platelet—fibrinogen interaction. At high flow rates, the interactions of platelets with both fibrinogen and von Willebrand factor become equally important. |
| doi_str_mv | 10.1007/s10517-020-04856-z |
| format | Article |
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At high flow rates, the interactions of platelets with both fibrinogen and von Willebrand factor become equally important.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-020-04856-z</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Fibrin ; Fibrinogen ; Internal Medicine ; Laboratory Medicine ; Pathology ; Von Willebrand factor</subject><ispartof>Bulletin of experimental biology and medicine, 2020-06, Vol.169 (2), p.229-232</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>COPYRIGHT 2020 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-8ebaa995de2682f9f2dee857b704afa0124e8b5e295611fd9d7382f170ba0413</citedby><cites>FETCH-LOGICAL-c422t-8ebaa995de2682f9f2dee857b704afa0124e8b5e295611fd9d7382f170ba0413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-020-04856-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-020-04856-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Avtaeva, Yu. 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At low flow rates, platelet adhesion almost totally depends on platelet—fibrinogen interaction. At high flow rates, the interactions of platelets with both fibrinogen and von Willebrand factor become equally important.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Fibrin</subject><subject>Fibrinogen</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Pathology</subject><subject>Von Willebrand factor</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kUFrFDEUx4MouFa_gKeAIF7SJplkJnNcF2ulBYsWPIbszMtOSjZZkwzSfvpmHQ8WSsnhkfd-v3d4f4TeM3rKKO3OMqOSdYRySqhQsiX3L9CKya4hinP2Eq1opYhQSr1Gb3K-PX5py1bIXLoAxQ0ZR4uvvSngoeD1OEF2MeAS8XWKBVwgm1iHI_45J2sGwC7gX1P0gD_7GGvb7A8eMjYFX7jdhM99_IN_VCO_Ra-s8Rne_asn6Ob8y83mglx9__pts74ig-C8EAVbY_pejsBbxW1v-QigZLftqDDWUMYFqK0E3suWMTv2Y9dUjnV0a6hgzQn6tKw9pPh7hlz03uUBvDcB4pw1F7yhbcdZU9EPC7ozHrQLNpZkhiOu120jhWiloJU6fYKqb4S9G2IA62r_kfDxP2EC48uUo59LPWR-DPIFHFLMOYHVh-T2Jt1pRvUxTr3EqWuc-m-c-r5KzSLlCocdJH0b5xTqRZ-zHgBUcqBg</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Avtaeva, Yu. 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The degree of platelet adhesion was evaluated by the intensity of laser light scattered from protein-coated optical surface with adhered platelets. The intensity of adhesion in whole blood samples at high flow rates was by 2.7 (2.4; 4.1) times higher than in platelet-rich plasma samples. Among the factors intensifying platelet adhesion in the whole blood at high flow rates, von Willebrand factor is of utmost importance. At low flow rates, platelet adhesion almost totally depends on platelet—fibrinogen interaction. At high flow rates, the interactions of platelets with both fibrinogen and von Willebrand factor become equally important.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10517-020-04856-z</doi><tpages>4</tpages></addata></record> |
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| subjects | Biomedical and Life Sciences Biomedicine Cell Biology Fibrin Fibrinogen Internal Medicine Laboratory Medicine Pathology Von Willebrand factor |
| title | Kinetics of Platelet Adhesion to Protein-Coated Surface in Whole Blood Samples at High Flow Rates |
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