Prospective Study Demonstrates Utility of EP-QuIC in Creutzfeldt–Jakob Disease Diagnoses

Prospectively acquired Canadian cerebrospinal fluid samples were used to assess the performance characteristics of three ante-mortem tests commonly used to support diagnoses of Creutzfeldt–Jakob disease. The utility of the end-point quaking-induced conversion assay as a test for Creutzfeldt–Jakob di...

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Veröffentlicht in:Canadian journal of neurological sciences 2021-01, Vol.48 (1), p.127-129
Hauptverfasser: Simon, Sharon L. R., Peterson, Anne, Phillipson, Clark, Walker, Jonathan M., Richmond, Meika, Jansen, Gerard H., Knox, J. David
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container_end_page 129
container_issue 1
container_start_page 127
container_title Canadian journal of neurological sciences
container_volume 48
creator Simon, Sharon L. R.
Peterson, Anne
Phillipson, Clark
Walker, Jonathan M.
Richmond, Meika
Jansen, Gerard H.
Knox, J. David
description Prospectively acquired Canadian cerebrospinal fluid samples were used to assess the performance characteristics of three ante-mortem tests commonly used to support diagnoses of Creutzfeldt–Jakob disease. The utility of the end-point quaking-induced conversion assay as a test for Creutzfeldt–Jakob disease diagnoses was compared to that of immunoassays designed to detect increased amounts of the surrogate markers 14-3-3γ and hTau. The positive predictive values of the end-point quaking-induced conversion, 14-3-3γ, and hTau tests conducted at the Prion Diseases Section of the Public Health Agency of Canada were 96%, 68%, and 66%, respectively.
doi_str_mv 10.1017/cjn.2020.139
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source Cambridge University Press Journals Complete
subjects Autopsies
Brief Communications
Consent
Creutzfeldt-Jakob disease
Health surveillance
Laboratories
Magnetic resonance imaging
Mutation
Patients
Proteins
title Prospective Study Demonstrates Utility of EP-QuIC in Creutzfeldt–Jakob Disease Diagnoses
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