Prospective Study Demonstrates Utility of EP-QuIC in Creutzfeldt–Jakob Disease Diagnoses
Prospectively acquired Canadian cerebrospinal fluid samples were used to assess the performance characteristics of three ante-mortem tests commonly used to support diagnoses of Creutzfeldt–Jakob disease. The utility of the end-point quaking-induced conversion assay as a test for Creutzfeldt–Jakob di...
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Veröffentlicht in: | Canadian journal of neurological sciences 2021-01, Vol.48 (1), p.127-129 |
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container_title | Canadian journal of neurological sciences |
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creator | Simon, Sharon L. R. Peterson, Anne Phillipson, Clark Walker, Jonathan M. Richmond, Meika Jansen, Gerard H. Knox, J. David |
description | Prospectively acquired Canadian cerebrospinal fluid samples were used to assess the performance characteristics of three ante-mortem tests commonly used to support diagnoses of Creutzfeldt–Jakob disease. The utility of the end-point quaking-induced conversion assay as a test for Creutzfeldt–Jakob disease diagnoses was compared to that of immunoassays designed to detect increased amounts of the surrogate markers 14-3-3γ and hTau. The positive predictive values of the end-point quaking-induced conversion, 14-3-3γ, and hTau tests conducted at the Prion Diseases Section of the Public Health Agency of Canada were 96%, 68%, and 66%, respectively. |
doi_str_mv | 10.1017/cjn.2020.139 |
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The positive predictive values of the end-point quaking-induced conversion, 14-3-3γ, and hTau tests conducted at the Prion Diseases Section of the Public Health Agency of Canada were 96%, 68%, and 66%, respectively.</description><identifier>ISSN: 0317-1671</identifier><identifier>EISSN: 2057-0155</identifier><identifier>DOI: 10.1017/cjn.2020.139</identifier><identifier>PMID: 32646535</identifier><language>eng</language><publisher>New York, USA: Cambridge University Press</publisher><subject>Autopsies ; Brief Communications ; Consent ; Creutzfeldt-Jakob disease ; Health surveillance ; Laboratories ; Magnetic resonance imaging ; Mutation ; Patients ; Proteins</subject><ispartof>Canadian journal of neurological sciences, 2021-01, Vol.48 (1), p.127-129</ispartof><rights>Her Majesty the Queen in Right of Canada as represented by the Minister of Health through the Public Health Agency of Canada, 2020. 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subjects | Autopsies Brief Communications Consent Creutzfeldt-Jakob disease Health surveillance Laboratories Magnetic resonance imaging Mutation Patients Proteins |
title | Prospective Study Demonstrates Utility of EP-QuIC in Creutzfeldt–Jakob Disease Diagnoses |
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