The efficacy of adding short-term psychodynamic psychotherapy to antidepressants in the treatment of depression: A systematic review and meta-analysis of individual participant data
We examined the efficacy of adding short-term psychodynamic psychotherapy (STPP) to antidepressants in the treatment of depression by means of a systematic review and meta-analysis of individual participant data, which is currently considered the most reliable method for evidence synthesis. A thorou...
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| Veröffentlicht in: | Clinical psychology review 2020-08, Vol.80, p.101886-101886, Article 101886 |
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| container_title | Clinical psychology review |
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| creator | Driessen, Ellen Dekker, Jack J.M. Peen, Jaap Van, Henricus L. Maina, Giuseppe Rosso, Gianluca Rigardetto, Sylvia Cuniberti, Francesco Vitriol, Veronica G. Florenzano, Ramon U. Andreoli, Antonio Burnand, Yvonne López-Rodríguez, Jaime Villamil-Salcedo, Valerio Twisk, Jos W.R. Cuijpers, Pim |
| description | We examined the efficacy of adding short-term psychodynamic psychotherapy (STPP) to antidepressants in the treatment of depression by means of a systematic review and meta-analysis of individual participant data, which is currently considered the most reliable method for evidence synthesis.
A thorough systematic literature search resulted in 7 studies comparing combined treatment of antidepressants and STPP versus antidepressant mono-therapy (n = 3) or versus antidepressants and brief supportive psychotherapy (n = 4). Individual participant data were obtained for all these studies and totaled 482 participants. Across the total sample of studies, combined treatment of antidepressants and STPP was found significantly more efficacious in terms of depressive symptom levels at both post-treatment (Cohen's d = 0.26, SE = 0.10, p = .01) and follow-up (d = 0.50, SE = 0.10, p |
| doi_str_mv | 10.1016/j.cpr.2020.101886 |
| format | Article |
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A thorough systematic literature search resulted in 7 studies comparing combined treatment of antidepressants and STPP versus antidepressant mono-therapy (n = 3) or versus antidepressants and brief supportive psychotherapy (n = 4). Individual participant data were obtained for all these studies and totaled 482 participants. Across the total sample of studies, combined treatment of antidepressants and STPP was found significantly more efficacious in terms of depressive symptom levels at both post-treatment (Cohen's d = 0.26, SE = 0.10, p = .01) and follow-up (d = 0.50, SE = 0.10, p < .001). This effect was most apparent at follow-up and in studies examining STPP's specific treatment efficacy. Effects were still apparent in analyses that controlled for risk of bias and STPP quality in the primary studies.
These findings support the evidence-base of adding STPP to antidepressants in the treatment of depression. However, further studies are needed, particularly assessing outcome measures other than depression and cost-effectiveness, as well as examining the relative merits of STPP versus other psychotherapies as added to antidepressants.
•Short-term psychodynamic psychotherapy (STPP) is a treatment for depression.•Adding STPP to antidepressants results in lower depressive symptom levels.•This effect is small at post-treatment and moderate at follow-up.•This effect can be related to STPP's specific treatment components.</description><identifier>ISSN: 0272-7358</identifier><identifier>EISSN: 1873-7811</identifier><identifier>DOI: 10.1016/j.cpr.2020.101886</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Antidepressant medication ; Combined treatment ; Depression ; Efficacy ; Individual participant data meta-analysis ; Short-term psychodynamic psychotherapy (STPP)</subject><ispartof>Clinical psychology review, 2020-08, Vol.80, p.101886-101886, Article 101886</ispartof><rights>2020 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-92bd279329c3b9a0fc8e83011f794488648bf05767fd7a91f0933b763270030a3</citedby><cites>FETCH-LOGICAL-c373t-92bd279329c3b9a0fc8e83011f794488648bf05767fd7a91f0933b763270030a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cpr.2020.101886$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids></links><search><creatorcontrib>Driessen, Ellen</creatorcontrib><creatorcontrib>Dekker, Jack J.M.</creatorcontrib><creatorcontrib>Peen, Jaap</creatorcontrib><creatorcontrib>Van, Henricus L.</creatorcontrib><creatorcontrib>Maina, Giuseppe</creatorcontrib><creatorcontrib>Rosso, Gianluca</creatorcontrib><creatorcontrib>Rigardetto, Sylvia</creatorcontrib><creatorcontrib>Cuniberti, Francesco</creatorcontrib><creatorcontrib>Vitriol, Veronica G.</creatorcontrib><creatorcontrib>Florenzano, Ramon U.</creatorcontrib><creatorcontrib>Andreoli, Antonio</creatorcontrib><creatorcontrib>Burnand, Yvonne</creatorcontrib><creatorcontrib>López-Rodríguez, Jaime</creatorcontrib><creatorcontrib>Villamil-Salcedo, Valerio</creatorcontrib><creatorcontrib>Twisk, Jos W.R.</creatorcontrib><creatorcontrib>Cuijpers, Pim</creatorcontrib><title>The efficacy of adding short-term psychodynamic psychotherapy to antidepressants in the treatment of depression: A systematic review and meta-analysis of individual participant data</title><title>Clinical psychology review</title><description>We examined the efficacy of adding short-term psychodynamic psychotherapy (STPP) to antidepressants in the treatment of depression by means of a systematic review and meta-analysis of individual participant data, which is currently considered the most reliable method for evidence synthesis.
A thorough systematic literature search resulted in 7 studies comparing combined treatment of antidepressants and STPP versus antidepressant mono-therapy (n = 3) or versus antidepressants and brief supportive psychotherapy (n = 4). Individual participant data were obtained for all these studies and totaled 482 participants. Across the total sample of studies, combined treatment of antidepressants and STPP was found significantly more efficacious in terms of depressive symptom levels at both post-treatment (Cohen's d = 0.26, SE = 0.10, p = .01) and follow-up (d = 0.50, SE = 0.10, p < .001). This effect was most apparent at follow-up and in studies examining STPP's specific treatment efficacy. Effects were still apparent in analyses that controlled for risk of bias and STPP quality in the primary studies.
These findings support the evidence-base of adding STPP to antidepressants in the treatment of depression. However, further studies are needed, particularly assessing outcome measures other than depression and cost-effectiveness, as well as examining the relative merits of STPP versus other psychotherapies as added to antidepressants.
•Short-term psychodynamic psychotherapy (STPP) is a treatment for depression.•Adding STPP to antidepressants results in lower depressive symptom levels.•This effect is small at post-treatment and moderate at follow-up.•This effect can be related to STPP's specific treatment components.</description><subject>Antidepressant medication</subject><subject>Combined treatment</subject><subject>Depression</subject><subject>Efficacy</subject><subject>Individual participant data meta-analysis</subject><subject>Short-term psychodynamic psychotherapy (STPP)</subject><issn>0272-7358</issn><issn>1873-7811</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9UUuP0zAQthBIlIUfwM1HLil-pHECp9WKl7TSXnbP1tQeU1eJEzzuovww_h8u7ZnTzOh7jGY-xt5LsZVCdh-PW7fkrRLq39z33Qu2kb3RjemlfMk2QhnVGL3rX7M3REchKqmVG_bn8YAcQ4gO3MrnwMH7mH5yOsy5NAXzxBda3WH2a4IpuutUDphhWXmZOaQSPS4ZiWpLPCZeUV4yQpkwlbPpFY9z-sRvOa1UcIJS3TI-R_xdPTyfsEADCcaVIp1FMfn4HP0JRr5Aruy41AXcQ4G37FWAkfDdtd6wp69fHu--N_cP337c3d43ThtdmkHtvTKDVoPT-wFEcD32WkgZzNC29Ultvw9iZzoTvIFBBjFovTedVkYILUDfsA8X3yXPv05IxU6RHI4jJJxPZFWrtOg6sesqVV6oLs9EGYNdcpwgr1YKe47IHm2NyJ4jspeIqubzRYP1hvqIbMlFTA59zOiK9XP8j_ovrHCdgw</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Driessen, Ellen</creator><creator>Dekker, Jack J.M.</creator><creator>Peen, Jaap</creator><creator>Van, Henricus L.</creator><creator>Maina, Giuseppe</creator><creator>Rosso, Gianluca</creator><creator>Rigardetto, Sylvia</creator><creator>Cuniberti, Francesco</creator><creator>Vitriol, Veronica G.</creator><creator>Florenzano, Ramon U.</creator><creator>Andreoli, Antonio</creator><creator>Burnand, Yvonne</creator><creator>López-Rodríguez, Jaime</creator><creator>Villamil-Salcedo, Valerio</creator><creator>Twisk, Jos W.R.</creator><creator>Cuijpers, Pim</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202008</creationdate><title>The efficacy of adding short-term psychodynamic psychotherapy to antidepressants in the treatment of depression: A systematic review and meta-analysis of individual participant data</title><author>Driessen, Ellen ; Dekker, Jack J.M. ; Peen, Jaap ; Van, Henricus L. ; Maina, Giuseppe ; Rosso, Gianluca ; Rigardetto, Sylvia ; Cuniberti, Francesco ; Vitriol, Veronica G. ; Florenzano, Ramon U. ; Andreoli, Antonio ; Burnand, Yvonne ; López-Rodríguez, Jaime ; Villamil-Salcedo, Valerio ; Twisk, Jos W.R. ; Cuijpers, Pim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-92bd279329c3b9a0fc8e83011f794488648bf05767fd7a91f0933b763270030a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antidepressant medication</topic><topic>Combined treatment</topic><topic>Depression</topic><topic>Efficacy</topic><topic>Individual participant data meta-analysis</topic><topic>Short-term psychodynamic psychotherapy (STPP)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Driessen, Ellen</creatorcontrib><creatorcontrib>Dekker, Jack J.M.</creatorcontrib><creatorcontrib>Peen, Jaap</creatorcontrib><creatorcontrib>Van, Henricus L.</creatorcontrib><creatorcontrib>Maina, Giuseppe</creatorcontrib><creatorcontrib>Rosso, Gianluca</creatorcontrib><creatorcontrib>Rigardetto, Sylvia</creatorcontrib><creatorcontrib>Cuniberti, Francesco</creatorcontrib><creatorcontrib>Vitriol, Veronica G.</creatorcontrib><creatorcontrib>Florenzano, Ramon U.</creatorcontrib><creatorcontrib>Andreoli, Antonio</creatorcontrib><creatorcontrib>Burnand, Yvonne</creatorcontrib><creatorcontrib>López-Rodríguez, Jaime</creatorcontrib><creatorcontrib>Villamil-Salcedo, Valerio</creatorcontrib><creatorcontrib>Twisk, Jos W.R.</creatorcontrib><creatorcontrib>Cuijpers, Pim</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical psychology review</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Driessen, Ellen</au><au>Dekker, Jack J.M.</au><au>Peen, Jaap</au><au>Van, Henricus L.</au><au>Maina, Giuseppe</au><au>Rosso, Gianluca</au><au>Rigardetto, Sylvia</au><au>Cuniberti, Francesco</au><au>Vitriol, Veronica G.</au><au>Florenzano, Ramon U.</au><au>Andreoli, Antonio</au><au>Burnand, Yvonne</au><au>López-Rodríguez, Jaime</au><au>Villamil-Salcedo, Valerio</au><au>Twisk, Jos W.R.</au><au>Cuijpers, Pim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The efficacy of adding short-term psychodynamic psychotherapy to antidepressants in the treatment of depression: A systematic review and meta-analysis of individual participant data</atitle><jtitle>Clinical psychology review</jtitle><date>2020-08</date><risdate>2020</risdate><volume>80</volume><spage>101886</spage><epage>101886</epage><pages>101886-101886</pages><artnum>101886</artnum><issn>0272-7358</issn><eissn>1873-7811</eissn><abstract>We examined the efficacy of adding short-term psychodynamic psychotherapy (STPP) to antidepressants in the treatment of depression by means of a systematic review and meta-analysis of individual participant data, which is currently considered the most reliable method for evidence synthesis.
A thorough systematic literature search resulted in 7 studies comparing combined treatment of antidepressants and STPP versus antidepressant mono-therapy (n = 3) or versus antidepressants and brief supportive psychotherapy (n = 4). Individual participant data were obtained for all these studies and totaled 482 participants. Across the total sample of studies, combined treatment of antidepressants and STPP was found significantly more efficacious in terms of depressive symptom levels at both post-treatment (Cohen's d = 0.26, SE = 0.10, p = .01) and follow-up (d = 0.50, SE = 0.10, p < .001). This effect was most apparent at follow-up and in studies examining STPP's specific treatment efficacy. Effects were still apparent in analyses that controlled for risk of bias and STPP quality in the primary studies.
These findings support the evidence-base of adding STPP to antidepressants in the treatment of depression. However, further studies are needed, particularly assessing outcome measures other than depression and cost-effectiveness, as well as examining the relative merits of STPP versus other psychotherapies as added to antidepressants.
•Short-term psychodynamic psychotherapy (STPP) is a treatment for depression.•Adding STPP to antidepressants results in lower depressive symptom levels.•This effect is small at post-treatment and moderate at follow-up.•This effect can be related to STPP's specific treatment components.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.cpr.2020.101886</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Antidepressant medication Combined treatment Depression Efficacy Individual participant data meta-analysis Short-term psychodynamic psychotherapy (STPP) |
| title | The efficacy of adding short-term psychodynamic psychotherapy to antidepressants in the treatment of depression: A systematic review and meta-analysis of individual participant data |
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